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Despite current therapies, there remains an unmet need for treatment for patients with hemophilia. The main parts of two phase 2 trials established clinical proof-of-concept for once-daily, subcutaneous concizumab prophylaxis in patients with hemophilia A/B with inhibitors (HAwI/HBwI; explorer4) and severe hemophilia A without inhibitors (HA; explorer5). Here, we present results from extension par
Humans have an impressive ability to communicate precise social intentions and desires with their voice - through vocal attitudes. Previous studies have shown how isolated acoustic features such as pitch can convey social attitudes, but have mostly worked with single attitudes and have not controlled for inter-speaker variability. Thus, the vocal behaviours used to produce social attitudes remain
The nitrogen cycle and its effect on carbon uptake in the terrestrial biosphere is a recent progression in earth system models. As with any new component of a model, it is important to understand the behaviour, strengths, and limitations of the various process representations. Here we assess and compare five land surface models with nitrogen cycles that are used as the terrestrial components of so
This report evaluates the person safety in case of fire at Scandic Infra City’s hotel and conference facilities in Upplands Väsby. A number of dimensioning fire scenarios were analyzed. The report concludes that the fire safety goal is not met for all scenarios.
Background: Calcitonin gene-related peptide (CGRP) release from trigeminal structures is central to migraine pathophysiology. This study employed an ex vivo model preserving anatomical continuity between the trigeminal nucleus caudalis (TNC) and trigeminal ganglion (TG) to investigate (1) whether TNC stimulation induces peripheral CGRP release from the TG and (2) the potential involvement of a dis
Molecular docking is a computational approach that predicts interactions between ligands and protein targets based on binding energies. In this study, the potential interactions of 1,8-cineole -one of the dominant components of Eucalyptus globulus oil- with the main protease (Mpro) and macrodomain (MacI) of SARS-CoV-2 were studied by molecular docking. Nine Mpro and four ManI structures available
Senior lecturer The aim of my research is to understand how our home galaxy, the Milky Way, and its stellar populations formed and evolved to what we observe today. There are many pieces in the puzzle and I focus on the observational ones, mapping the detailed structure in terms of abundances, kinematics, and ages, using high-resolution spectra obtained with the large optical telescopes around the
https://www.astro.lu.se/~tbensby - 2026-07-17
Professor of astronomy Contact details Email: sofia [dot] feltzing [at] mgeo [dot] lu [dot] seOrganisation Department of Earth and Environmental Sciences (MGeo) Service point: 16 WebpageSofia Feltzings profile in Lund University research portalOther affiliations Health and safety representative Department of Earth and Environmental Sciences (MGeo) Member of Strategic Research Area eSSENCE: The e-S
https://www.geology.lu.se/sofia-feltzing - 2026-07-17
Director of graduate studies Contact details Email: thomas [dot] bensby [at] fysik [dot] lu [dot] se Phone: +46 46 222 73 24Organisation Astrophysics Room number: A427 Service point: 14 WebpageThomas Bensbys profile in Lund University research portalOther affiliations Health and safety representative Astrophysics Director of third cycle studies Department of Physics Publications Displaying of publ
https://www.fysik.lu.se/en/thomas-bensby - 2026-07-17
Bakgrund: Prokrastinering är uppskjutande av utförande av aktivitet trots vetskapen om att det kan ge negativa konsekvenser i längden. Det är ett fenomen som är väl beforskat inom den vetenskapliga disciplinen psykologi men i stort sett outforskat inom arbetsterapin och aktivitetsvetenskapen. Syfte: Syftet med denna studie var att kartlägga prokrastinering samt förekommande behandlingar ur ett aktBackground: Procrastination is the postponement of performance of an activity despite the knowledge that it can have negative consequences in the long run. It is a phenomenon that is well researched in the scientific discipline of psychology but largely unexplored in occupational therapy and occupational science. Aim: The aim of this study was to map procrastination and existing treatments from th
Cold protective clothing was studied in 2 European Union projects. The objectives were (a) to examine different insulation calculation methods as measured on a manikin (serial or parallel), for the prediction of cold stress (IREQ); (b) to consider the effects of cold protective clothing on metabolic rate; (c) to evaluate the movement and wind correction of clothing insulation values. Tests were ca
CONTEXT: Tuberculosis (TB) is an increasing global problem, despite effective drug therapies. Access to TB therapy during conflict situations has not been studied. OBJECTIVE: To determine the effect of irregular TB treatment due to an armed conflict in Guinea-Bissau, West Africa. DESIGN, SETTING, AND PATIENTS: Ongoing retrospective cohort study conducted in the capital city of Bissau among 101 pat
Psychiatric, physical and biological aspects of posttraumatic stress disorder (PTSD) may be associated with dysfunctions in several cellular processes including nitric oxide (NO) production. NO is synthesized from arginine in a reaction carried out by NO synthase (NOS) enzymes. The recently introduced "global arginine bioavailability ratio" (GABR; ratio of arginine to [ornithine+ citrulline]) has
In this paper unequal error-correcting capabilities of convolutional codes are studied. State-transition graphs are used for investigating the error-correcting capabilities for specific inputs or outputs of given convolutional encoding matrices. Active burst input- and output-distances are defined and shown to be generalizations of the active burst distance. These new distances provide better esti
Manganese(IV)-oxo complexes are often invoked as intermediates in Mn-catalyzed C-H bond activation reactions. While many synthetic MnIV-oxo species are mild oxidants, other members of this class can attack strong C-H bonds. The basis for these reactivity differences is not well understood. Here we describe a series of MnIV-oxo complexes with N5 pentadentate ligands that modulate the equatorial lig
Recent advancements in almost all aspects of hemophilia treatment have vastly improved patient care and management, and new and emerging treatments hold the promise of further progress. However, there remains a scarcity of data on long-term outcomes in hemophilia, particularly among those patients with inhibitors, for whom no validated outcome assessment tools are currently available. At the 15th
Hepatocellular carcinoma (HCC) is associated with high mortality and the current therapy for advanced HCC, Sorafenib, offers limited survival benefits. Here we assessed whether combining the TLR3 agonist: lysine-stabilized polyinosinicpolycytidylic- acid (poly-ICLC) with Sorafenib could enhance tumor control in HCC. Combinatorial therapy with poly-ICLC and Sorafenib increased apoptosis and reduced
Objectives To assess the association between neonatal BCG vaccination and mortality between 28 days and 3 years of age among tuberculosis (TB)-exposed and TB-unexposed children. Design Prospective cohort study. Setting Bandim Health Project runs an urban Health and Demographic Surveillance site in Guinea-Bissau with registration of mortality, vaccination status and TB cases. Participants Children
Major depressive disorder (MDD) has been linked to mitochondrial defects, which could manifest in mitochondrial DNA (mtDNA) polymorphisms or mutations. Additionally, copy number of mtDNA (mtDNA-cn) can be quantified in peripheral blood mononuclear cells (PBMC)s, indirectly reflecting cellular energetics, or in the circulating cell-free mtDNA (ccf-mtDNA) levels, which may reflect a fraction of the
