Thiopurine S-methyltransferase (TPMT) deficient patients develop life threatening haematotoxicity (for example, pancytopenia) when treated with a standard dose of azathioprine (AZA) and 6-mercaptopurine (6-MP) due to excessive accumulation of cytotoxic metabolites. At present, it is generally recommended that these patients should not receive AZA or 6-MP treatment for inflammatory bowel disease. W

Adaptive time-stepping based on linear digital control theory has several advantages: the algorithms can be analyzed in terms of stability and adaptivity, and they can be designed to produce smoother stepsize sequences resulting in significantly improved regularity and computational stability. Here, we extend this approach by viewing the closed-loop transfer map H-(φ) over cap: log (φ) over cap ba

In quality assurance programs, we want indicators of software quality, especially software correctness. The number of found defects during inspection and testing are often used as the basis for indicators of software correctness. However, there is a paradox in this approach, since the remaining defects is what impacts negatively on software correctness, not the found ones. In order to investigate

Background. An altered renal function is an essential component of the patho-physiology of pre-eclampsia. The plasma levels of low molecular mass proteins, e. g. beta-trace protein, beta-2-microglobulin and cystatin C, are increased in the third trimester of normal pregnancy. The plasma levels of cystatin C and beta-2-microglobulin are further increased in preeclampsia, and the cystatin C level ha

Föreliggande rapport handlar om demokrati, delaktighet och inflytande i två av Lomma kommuns grundskolor. Elevers rättigheter till inflytande finns föreskrivet i barnkonventionen, skollagen, kommunala styrdokument, samt i enskilda skolors lokala vardag. Vad innebär elevinflytande? Hur gestaltas elevinflytandet, formellt och informellt? Hur upplever elever möjligheterna till delaktighet i undervisn

The main contributions of this thesis are in the area of approximation and online algorithm design and derivation of lower bounds on the approximability for a number of combinatorial optimization problems with applications in computational biology and computational geometry. Approximation and online algorithms are fundamental tools used to deal with computationally hard problems and problems in wh

In order to model the individual electron transfer steps from the manganese cluster to the photooxidized sensitizer P680+ in Photosystem II (PS II) in green plants, the supramolecular complex 4 has been synthesized. In this complex, a ruthenium(II) tris-bipyridine type photosensitizer has been linked to a manganese(II) dimer via a substituted l-tyrosine, which bridges the manganese ions. The trinu

Popular Abstract in Swedish Avhandlingen beskriver och diskuterar de tidskrifter och böcker som muslimer i Sverige skrivit på svenska under 1900-talet. Framförallt gås innehållet i tidskriften Salaam - Islamisk Tidskrift (grundad 1986) igenom. Innehållet diskuteras i förhållande till hur islam har globaliserats de senaste tre decennierna. En slutsats är att Salaams skribenter har försökt att knytaThis dissertation focuses on written Islamic discourses in Swedish, especially the journal Salaam - Islamisk tidskrift. The journal first appeared in 1986 and is a part of the activities of Islamiska Informationsföreningen. From the beginning, Salaam has been edited by female converts to Islam in their twenties or early thirties. Female converts also account for a large number of the texts that ha

The fate and effects of 2,4,6-trinitrotoluene (TNT) at marine ammunition dumping sites are essentially unknown. The objective of this study was to examine the release from solid TNT to seawater when covered by sediment of two different types (sandy and fine-grained) and thickness (0, 1 2, and 4 cm), under different temperatures (5, 10, and 20 degrees C), and light conditions (ambient daylight and

In order to search for novel giant-magnetoresistance systems, we fabricated and investigated narrow constrictions in the layers of the ferromagnetic semiconductor (Ga,Mn)As. We found that constrictions a few hundred nanometers wide, tailored by means of the electron-beam lithography and wet etching, were not conducting at liquid helium temperatures unless illuminated, probably due to the trapping

Popular Abstract in Swedish Yrsel är ett vanligt förekommande symtom hos patienter som besöker primärvården. Det är det vanligaste symtomet hos äldre patienter och har identifierats som en riskfaktor för fall och nedsatt funktion i innerörats balansorgan har hittats hos patienter med höftfrakturer och handledsfrakturer. Man har också påvisat att 25 % av patienterna med kvarstående besvär efter whiDizziness is a common reason for visits to primary health care, especially among elderly patients. From a physiotherapeutic perspective, this thesis aims to study the assessment and treatment of dizzy patients in primary health care. Interventions in papers I, III and IV comprised a vestibular rehabilitation programme. In paper I, patients with multisensory dizziness were randomized to interventi

Ozone in the atmosphere, mainly in the stratosphere, absorbs most of the ultraviolet-B (wavelength 280-315 nm) radiation from the sun, which can destroy DNA and other biologically important molecules and, thereby, damage living organisms. Due to the pollution of the atmosphere by humans, the ozone layer is presently being depleted, more rapidly at higher latitudes than at lower, and more rapidly o

Om Matts Leiderstams konst.

Essä om filosofiska idéer i Éric Rohmers filmer.