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Molecular subtyping has been a major focus of bladder cancer research over the past decade. Despite many promising associations with clinical outcomes and treatment response, its clinical impact has yet to be defined. As part of the 2022 International Society of Urological Pathology Conference on Bladder Cancer, we reviewed the current state of the science for bladder cancer molecular subtyping. O
The compositions of alternative jet fuels can vary radically, and the consequences of these differences are a subject of ongoing investigation. Numerical combustion simulations are vital to this research and require chemical reaction mechanisms that efficiently and accurately capture the chemical pathways of combustion. Here, we present the recently developed Z79 collection of small pathway-centri
We investigate the persistence of embedded eigenvalues for a class of magnetic Laplacians on an infinite cylindrical domain. The magnetic potential is assumed to be C2 and asymptotically periodic along the unbounded direction of the cylinder, with an algebraic decay rate toward a periodic background potential. Under the condition that the embedded eigenvalue of the unperturbed operator lies away f
Importance: The etiologic interrelationship of 4 rare/controversial psychotic disorders (delusional disorder [DD], acute psychoses [AP], psychosis not otherwise specified [PNOS], and schizoaffective disorder [SAD]) is poorly understood. Objective: To assess levels of the family genetic risk score (FGRS) for schizophrenia (SZ), bipolar disorder (BD), and major depression (MD) in individuals with DD
This review covers recent advances (2023–2024) in neuroimaging research into the pathophysiology, progression, and treatment of Alzheimer's disease (AD) and related dementias (ADRD). Despite the rapid emergence of blood-based biomarkers, neuroimaging continues to be a vital area of research in ADRD. Here, we discuss neuroimaging as a powerful tool to topographically visualize and quantify amyloid,
Aims Short, uncemented hip stems might provide a favourable alternative in total hip arthroplasty (THA) by preserving proximal bone mass through reduced strain-adaptive remodelling. We evaluated and compared the migration and periprosthetic bone remodelling of a short stem with and without a collar, using radiostereometric analysis (RSA) to measure implant migration and dual-energy X-ray absorptio
In this paper I’m concerned with the functional role of singular terms and how it can be used to construct a pragmatist theory of what it takes to understand reference. I argue that there are, at least, two distinct functions which singular terms fulfil, what I will call the talking-about and picking-out functions respectively. Both are, in one sense, ways that a term aids our understanding by spe
Background Primary ciliary dyskinesia (PCD) represents a group of rare hereditary disorders characterised by deficient ciliary airway clearance that can be associated with laterality defects. We aimed to describe the underlying gene defects, geographical differences in genotypes and their relationship to diagnostic findings and clinical phenotypes. Methods Genetic variants and clinical findings (a
High-order harmonic generation (HHG) in gases has been studied for almost 40 years under many different conditions, varying the laser wavelength, intensity, focusing geometry, target design, gas species, etc. However, no systematic investigation of the effect of the pulse duration has been performed despite its expected impact on phase-matching of the high-order harmonics. Here, we develop a compa
The Gaia satellite revealed a remarkable spiral pattern (‘phase spiral’, PS) in the z–Vz phase–plane throughout the solar neighbourhood, where z and Vz are the displacement and velocity of a star perpendicular to the Galactic plane. As demonstrated by many groups, the kinematic signature reflects the Galactic stellar disc’s response to a dynamical disturbance some 0.3–3 Gyr ago. However, previous
The skin is the outermost organ that serves as the host's live, microbiota-inhabited physical border, evolved to cope with continuous confrontation by a wide variety of environmental elements. This dynamic borderline is prone to injury and damage. Therefore, to deliver on the critical demands for protection, skin is tightly associated with innate and adaptive defense mechanisms that ensure homeost
When electrically stimulated, electroactive polymers (EAPs) respond with mechanical deformation. The goal of this work is to design electrode and EAP layouts simultaneously in structures using density-based, multi-material topology optimization. In this novel approach the layout of electrodes and EAP material are not given a priori but is a result from the topology optimization. Material interpola
Recessive diseases arise when both copies of a gene are impacted by a damaging genetic variant. When a patient carries two potentially causal variants in a gene, accurate diagnosis requires determining that these variants occur on different copies of the chromosome (that is, are in trans) rather than on the same copy (that is, in cis). However, current approaches for determining phase, beyond pare
Breath-hold ECG-gated cardiovascular magnetic resonance (CMR) imaging is challenging during exercise due to motion, ECG-problems, and lengthy scans. To facilitate time-resolved volumetric measures from exercise-CMR, we aimed to develop a method for constructing time-resolved ventricular cines from real-time free-breathing exercise-CMR. Time-resolved ventricular cines were semi-automatically constr
Background: Testicular germ cell cancer (TGCC) originates during fetal life. Fetal exposure to environmental chemicals may contribute to its development, but epidemiological data are lacking. We investigated per- and polyfluoroalkyl substances (PFAS), which can act as endocrine disruptors during fetal development, and TGCC risk in adulthood. Methods: We conducted a nested case-control study of 549
This paper presents the exploration of GPU-accelerated block-wise decompositions for zero-forcing (ZF) based QR and Cholesky methods applied to massive multiple-input multiple-output (MIMO) uplink detection algorithms. Three algorithms are evaluated: ZF with block Cholesky decomposition, ZF with block QR decomposition (QRD), and minimum mean square error (MMSE) with block Cholesky decomposition. T
The lifelong risk of stroke following adverse pregnancy outcomes, and potential causality, are unknown. This study examined five major adverse pregnancy outcomes and long-term risk of stroke in a large population-based cohort. Methods A national cohort study was conducted of all 2 201 393 women with a singleton delivery in Sweden during 1973–2015, followed up for stroke through 2018. Cox regressio
Effective governance and management of ecosystem functions to promote human well-being and social equity require a clear understanding of supply and demand dynamics. While this is widely acknowledged in assessments of ecosystem services, it remains largely neglected for ecosystem disservices, despite many ecosystem functions generating both services (benefits) and disservices (costs) depending on
Generalist parasites must adapt to diverse host environments to ensure their survival and transmission. These adaptations can involve fixed genetic responses, transcriptional plasticity, or epigenetic mechanisms. The avian malaria parasite Plasmodium homocircumflexum offers an ideal model for studying transcriptional variation across hosts. We experimentally inoculated P. homocircumflexum into dif
