BACKGROUND: Acute myeloid leukemia (AML) is an aggressive hematological neoplasm. Little improvement in survival rates has been achieved over the past few decades. Necroptosis has relationship with certain types of malignancies outcomes. Here, we evaluated the diagnostic ability, prognostic capacity of necroptosis-related genes (NRGs) and the effect of their copy number variations (CNVs) in AML.ME

Intracellular delivery is crucial in biological and medical studies. Although many molecular tools have been created for cell-based gene therapies, it remains challenging to introduce external molecules into cells. As one of the most popular non-viral transfection methods, electroporation induces transient pores in the cell membrane by applying an external electric field. Unsatisfactory transfecti

Quark spin effects in e+e- annihilation to pseudoscalar and vector mesons are implemented for the first time in the pythia Monte Carlo event generator. The spin-dependent fragmentation of the string stretched between the produced quark-antiquark pair with correlated spin states is described by the string+P30 model implemented in the string fragmentation routine of pythia by using the StringSpinner

High levels of economic inequality are widely viewed as a key challenge facing bothadvanced industrial and developing economies. Country-level studies have consistentlyshown a negative link between income inequality and trust in others. This is typicallyattributed to greater social distance within unequal societies. Do we observe similarrelationships within organisations? This is an important ques

Management scholarship is beginning to grapple with the growing popularity of machine learning (ML) as an analytical tool. While quantitative research in our discipline remains heavily influenced by positivist thinking and statistical modelling underpinned by null hypothesis significance testing, ML is increasingly used to solve technical, computationally demanding problems. In this paper, we argu

At the end of September, David Malpass, the president of the World Bank, was heavily criticized after failing to acknowledge anthropogenic climate change [henceforth called climate change (1)]. Although he later apologized for and revised his remarks, they sparked a renewed public debate on the existence of climate changedeniers and their impact on our transition toward a more sustainable future (

Decarbonization policies require public support to be implemented and to remain in legislation. Examinations of public support for climate policies tend to focus on asmall number of policy instruments and/or use hypothetical instead of real policy proposals. Here, we address these criticisms by examining public support acrossfour distinct policy instruments– command-and-control, market-based, info

Understanding predictors of climate policy support is important for tackling climate change. Previous research demonstrated that policy support is partially driven by cultural worldviews. Yet, treating policies as a homogeneous concept, this literature neglected the existence of different policy types. Making this distinction is important because each type implies a distinct solution to the same p

Die Studie beruht auf einer repräsentativen Beschäftigtenumfrage. Die Erhebung dokumentiert erstmals mit einem Fokus auf Beschäftigte, wie diese über den Klimawandel unddie anstehende sozial-ökologische Transformation denken. Sie zeigt, dass sich Beschäftigte in der Tendenz gut informiert fühlen und zugleich sehr besorgt über den Klimawandel sind. Viele sehen eine hohe Dringlichkeit für Maßnahmen

Anhand einer repräsentativen Umfrage unter Beschäftigten analysiert das vorliegende Paper die Zustimmung zu energiepolitischen Maßnahmen und die Wahrnehmung sozioökonomischer Folgen entlang politischer Parteipräferenzen. Zwischen den parteipolitischen Linien „Mitte links“ (SPD, Grüne, Die Linke), „Mitte rechts“ (CDU/CSU, FDP) und „populistisch“ (BSW, AfD) finden sich deutliche Unterschiede, aber ü

AI-enabled technologies are developing rapidly, but the first wave of the Digit Employers’ Digital Practices at Work Survey (2021-22) showed that their use by firms is not yet widespread. This Data Commentary presents findings from the second wave of the Survey, conducted during 2023, based on responses from 1,150 firms.The findings show that adoption of AI-enabled technologies by UK firms remains

We have access to ever-increasing amounts of digital data. Yet we know little about how digital technologies are transforming employers’ work practices in British firms. This is because we lack representative, reliable data about these practices at the organisation-level. Existing data tend to:draw from independent consultancy projects and reports;be relatively narrow in scope or rely on potential