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Discovering Subgroups of Children With High Mortality in Urban Guinea-Bissau : Exploratory and Validation Cohort Study

divided the data set temporally, assessing the persistence of identified subgroups over different periods. The reassessment of mortality risk used the targeted maximum likelihood estimation (TMLE) method to achieve more robust causal modeling. Results: We analyzed data from 21,005 children. The mortality risk (6 weeks to 3 years of age) was 5.2% (95% CI 4.8%-5.6%) for children born between 2003 an

Unravelling the mechanisms of CE-SSFP in imaging myocardium at risk : The effect of relaxation times on myocardial contrast

Purpose: The aim of this study was to investigate the contrast mechanisms of Contrast-enhanced steady-state free-precession (CE-SSFP) through the utilization of Bloch simulations in an experimental porcine model and in patients with acute myocardial infarction. Methods: Six pigs and ten patients with myocardial infarction underwent CMR and tissue characterization at 1.5 T whereas a Bloch simulatio

Familial clustering of unexplained heart failure – A Danish nationwide cohort study

Aims: To determine whether a family history of unexplained heart failure (HF) in first-degree relatives (children or sibling) increases the rate of unexplained HF. Methods and results: Using Danish nationwide registry data (1978–2017), we identified patients (probands) diagnosed with first unexplained HF (HF without any known comorbidities) in Denmark, and their first-degree relatives. All first-d

Low-Protein Infant Formula Enriched with Alpha-Lactalbumin during Early Infancy May Reduce Insulin Resistance at 12 Months : A Follow-Up of a Randomized Controlled Trial

High protein intake during infancy results in accelerated early weight gain and potentially later obesity. The aim of this follow-up study at 12 months was to evaluate if modified low-protein formulas fed during early infancy have long-term effects on growth and metabolism. In a double-blinded RCT, the ALFoNS study, 245 healthy-term infants received low-protein formulas with either alpha-lactalbum

Explorations of interlinked energy and redox metabolism in two industrially applied microorganisms

Anaerobic fermentation, compared to aerobic processes, remains the most scalable method for bioproduction of compounds. This is due to that aerobic microbial processes require large amounts of energy and are unable to satisfy the oxygen demand of a high-density microbial biomass. Thus, anaerobic microbes are readily scalable to large volumes. It was found that most anaerobic microbes have evolved

Challenges and opportunities for increasing the use of low‑risk plant protection products in sustainable production. A review

Plant production systems worldwide are struggling to meet the diverse and increasing needs of humankind while also facing challenges such as climate change and biodiversity loss. This, combined with the desirable transition from the use of conventional pesticides to more sustainable plant protection solutions, has led to an urgent, and increasing, need for lowrisk plant protection products (PPPs)

Akkermansia muciniphila exoglycosidases target extended blood group antigens to generate ABO-universal blood

Matching donor and recipient blood groups based on red blood cell (RBC) surface ABO glycans and antibodies in plasma is crucial to avoid potentially fatal reactions during transfusions. Enzymatic conversion of RBC glycans to the universal group O is an attractive solution to simplify blood logistics and prevent ABO-mismatched transfusions. The gut symbiont Akkermansia muciniphila can degrade mucin

Singular potentials, rigidity and recurrence in low dimensional dynamics

In the first part of this thesis we study the behaviour of the equilibrium measure and the Birkhoff sums for a singular potential over the doubling map. A complete multifractal analysis for the the Birkhoff sums and the equilibrium measure (for the ’appropriate’ scaling) is given in Paper I. In Paper II we prove a parameter continuity property of the pressure function for a family of singular pote

Defensores ambientales trabajan para mantener el papel pacificador de la naturaleza en el Norte de Uganda : Hay tres maneras en que se puede pensar la naturaleza para iniciar procesos sostenibles de paz y desarrollo

En los últimos años, ha habido una “ofensiva” contra defensores ambientalistas en Uganda. Periodistas, estudiantes, campesinos y habitantes rurales están defendiendo su medioambiente, protestan y se movilizan contra el trato injusto y la migración forzada provocada por las infraestructuras para el combustible fósil, la agroindustria, energía hidráulica o la compensación de las emisiones de carbono

Very short sleep duration reveals a proteomic fingerprint that is selectively associated with incident diabetes mellitus but not with incident coronary heart disease : a cohort study

Background: The molecular pathways linking short and long sleep duration with incident diabetes mellitus (iDM) and incident coronary heart disease (iCHD) are not known. We aimed to identify circulating protein patterns associated with sleep duration and test their impact on incident cardiometabolic disease. Methods: We assessed sleep duration and measured 78 plasma proteins among 3336 participants

Study of the 7Be(d,3He)6Li* reaction at 5 MeV/u

The measurement of the 7Be(d,3He)6Li* transfer cross section at 5 MeV/u is carried out. The population of the 2.186 MeV excited state of 6Li in this reaction channel is observed for the first time. The experimental angular distributions have been analyzed in the finite range DWBA and coupled-channel frameworks. The effect of the 7Be(d,3He)6Li reaction on both the 6Li and 7Li abundances are investi

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This document is part of a project that aims to design environmental strategies focused on addressing previously evaluated issues through primary and secondary information, as well as community surveys. This will be achieved through workshops and environmental education training primarily for students, administrators, teachers, cleaning staff, and maintenance personnel of the institution. The obje

Truth, humane treatment, and identity: perspectives on the legitimacy of the public and private health sectors during Covid in Zambia

Legitimacy is necessary for resilience and trust helps to legitimize health systems. Providing services during Covid has relied on both the private and public sectors but there is little information on differences in trust between these sectors during shocks like Covid and how it may impact the health system’s legitimacy. The purpose of this study was to explore community trust in the public and p

How dare we? The relation between language use, global identity, and climate activism

Identifying with and caring for people all over the world (i.e., a global identity) is positively related to pro-environmental behaviour. However, less is known how to foster such a global identity. Drawing on social identity theory, we investigated whether using inclusive (vs. exclusive) language in the context of demonstrations for climate protection increases people’s global identity. Moreover,