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Deciphering New Neurocircuitries to Modulate Appetite

Food for Thought, or Thought for Food? Obesity affects 12 % of adults worldwide (GBD 2015 Obesity Collaborators, 2017). This number is only expected to increase in the future. Serious risks are associated with obesity such as heart disease, high blood pressure, and type two diabetes (Pantalone et al., 2017). There are not currently effective and safe methods to aid weight loss (Ruban et al., 2019

Effects of anti-TSLP treatment on the bronchial epithelial viral immune transcriptome and airway epithelial–smooth muscle cell crosstalk

Hur påverkar anti-TSLP cellkommunikation och inflammation i lungan? Astma är en kronisk andningssjukdom som påverkar miljontals människor runt om i världen. Sjukdomen kännetecknas av luftvägsinflammation, överkänslighet och obstruktion, vilket leder till symtom som väsande andning, andnöd och hosta. Ny forskning visar att läkemedlet Tezepelumab, ett anti-TSLP läkemedel som blockerar TSLP, kan minBackground: Asthma, a prevalent chronic lung disease, affecting millions worldwide, is characterised by airway inflammation and increased smooth muscle mass and constriction, leading to the narrowing of the airway walls. Recent biologics have emerged as promising treatments for asthma. This study focuses on Tezepelumab, a monoclonal antibody targeting TSLP, which has been shown to improve airway h

Potential involvement of t-circles in the Alternative Lengthening of Telomeres in Naumovozyma castellii

Merry Go Round: Rolling-circle telomere elongation Imagine a shoelace. At the end of the shoelace, there is a protective piece called an aglet, keeping the fibers together. A human chromosome is a bit like that, too – long and linear, with a characteristic structure at the end called the telomere, which protects the chromosome from instability. With each cell division, a piece of the telomeric

Profiling Extracellular Vesicle Proteome of Small Cell Lung Cancer Patients for Non-Invasive Subtyping and Monitoring

Small cell lung cancer (SCLC) is a highly aggressive form of cancer, characterized by a particularly poor prognosis. Subsequently, it has a very low five-year survival rate of only 6%. At the clinic, patients are either diagnosed at advanced stages where care is more palliative and with few therapeutic options or, when diagnosed at earlier stages, respond very positively to first-line treatments b

Development of a multiplex PCR for detection of Fusobacterium necrophorum, Streptococcus pyogenes and Streptococcus dysgalactiae subspecies equisimilis

Streptococcus pyogenes, or group A streptococci (GAS) is a well known agent of pharyngitis. The same goes for the closely related S. dysgalactiae subspecies equisimilis (SDSE). Recent data indicates that a third pathogen called Fusobacterium necrophorum, with similarly severe complications to GAS is the second most common pathogen in pharyngitis. These infections cause the greatest damage in low

Meal-induced release of the incretins GLP-1 and GIP in healthy men and the effect of thylakoids

Frisättning av insulin- och mättnadsstimulerande tarmhormoner efter intag av extrakt från spenat Introduktion och Bakgrund Fetma är en växande hälsoutmaning då den kan leda till kronisk sjukdom som typ II diabetes och hjärt-kärlsjukdom. Därför sker mycket forskning för att underlätta viktminskning hos överviktiga. Ny medicin har fokuserat på insulinfrisättande tarmhormoner, som hjälper till att s

The Effect of Cartilage Oligomeric Matrix Protein on Anti-Tumor Immune System

Kroppens goda och onda sida i cancer Alla är familiära med sjudomen cancer, antignen via en bekant, vetskap om sjukdomen eller personligt. Trots att det är en relativt vanlig sjudom betyder inte det att kroppen inte har ett försvar mot cancern, vi har faktiskt vårt immunförsvar. Några av de viktiga celler vi har som skydd är våra T-celler, en del av våra vita blodkroppar. Dock, kan kroppen också

Labelling of Voltage Gated Sodium Channels

DNA Encoded Library (DEL) screening has emerged as a transformative technology in pharmaceutical research, enabling the high-throughput screening of billions of compounds. While DEL screening has been successful in identifying small molecule ligands for various protein targets, challenges remain in targeting specific classes of proteins, such as membrane proteins, which are challenging to purify a

Setting up WebAssembly in a Cloud Environment that Supports AMD Secure Encrypted Virtualization

Data confidentiality and security in cloud computing is a major concern for both service providers and users. The industry’s approach to enhancing trust and data security is to provide Trusted Execution Environments (TEEs) as secure and encrypted instances within Central Processing Units (CPUs) to execute and process user data in cloud environments. However, this approach raises issues and practic

Actors’ opinions of Goodyera repens regarding forestry and conservation in Sweden. A literature review

Biologisk mångfald är ett begrepp som alla känner till och dess betydelse. Det påverkar oss alla på alla möjliga sätt och vi kan enkelt påverka det genom att förändra de minsta sakerna i naturen. Flera arter är extremt känsliga för förändringar och med en mindre förändring i sin miljö försvinner de. Rödlistade arter är arter som är sårbara, orkidé är en art som alla typer är rödlistade i Sverige. The aim of this literature study was to understand the different perspectives of actors within forestry and conservation in terms of the species goodyera repens, and its debate.This study focuses on the red-listed orchid G. repens. A comparation of different actors was done, and it can be seen that the opinions of the actors’ are very different from each other. In summary, the actors who were more

Mapping the Funding Strategies of Climate Change Mitigation Donors in the USA

The impacts of climate change have worsened, and natural hazards are becoming more unpredictable, and their consequences more severe. Stakeholders have called for increased funding for climate change mitigation initiatives to combat the worsening effects on people and the planet. This study explores the differences between public and private sector donors in the USA and their strategies for fundin

Äldres upplevelser av att vårdas och vistast på akutmottagning. En litteraturstudie

Bakgrund: Äldre är en växande grupp av vårdsökande på akutmottagningarna och resurserna ökar inte i takt med det ökade behovet av vård. Vistelsetiden på akutmottagningen ökar årligen och hårdast drabbas äldre patienter. Att besöka akutmottagningen kan vara en utmaning för de äldre i den hektiska miljön som finns på akutmottagningen. Syfte: Syftet med studien var att undersöka hur äldre upplevde atBackground: The elderly are a growing group of care seekers in the emergency departments and the resources do not increase in pace with the increased need for care. The length of stay in the emergency department increases annually, and older patients are hit hardest. Visiting the emergency department can be a challenge for the elderly in the busy environment found in the emergency department. Purp

En resa till motsägelsernas land : Rumänien i svenska guideböcker 1964–1981

A Journey to the Land of Contradictions - The Depiction of Romania in Swedish Guidebooks 1964-1981. In the construction of countries as tourist destinations, travel literature – such as guidebooks – plays an integral role in deciding what places to visit and how these should be perceived. The Socialist Republic of Romania began a large-scale investment in its tourism industry in the 1950s, with a

Magasin

Syftet med kandidatkursen Urban kontext (AAHF26) är att undersöka hur arkitektur förhåller sig till ett urbant sammanhang. Kursen understryker vikten av att undersöka arkitektur från ett relationellt perspektiv. Tonvikten ligger på hur arkitektur kopplar till omgivningen. I början av kursen fick vi studenter möjlighet att välja mellan ett antal platser, på förhand valda av kursansaviga lärare, i L

The Future of Employer Branding: How are the expectations and values of Generation Z reshaping employer branding strategies and what are the implications for Managers?

Purpose: The purpose of this paper is to examine how the entry of Generation Z in the workforce might affect the future of employer branding. This paper analyzes how employer branding is done currently and the differences between Gen Z and its preceding generations. Managerial suggestions on how to effectively approach Gen Z in terms of employer branding are given. Methodology: In this paper a

Groundwater storage loss calculation using InSAR and Hydromechanical equations

This master thesis investigates groundwater storage loss in the Ararat Valley’s aquifer system, driven by intensive groundwater extraction and associated with subsidence risks. Using both InSAR data and hydromechanical analysis, this research shows coherent aquifer storage changes related to localized changes in ground deformations. Non-compliance with recommended well-spacing has exacerbated stre

Design and Planning of Biofuels Produced from Algae

This thesis investigates the profitability of converting microalgae into biofuel using hydrothermal liquefaction the goal is to produce 100 000 tons of bio-oil each year. It explores various microalgae species and cultivation methods, identifying Chlorella vulgaris with a rotating attached biofilter as the optimal choice due to its high biomass concentration, eliminating the need for dewatering an

Simulating and dimensioning an NH3 adsorber for decentralized production

Med hjälp av programmeringsspråket python samt matematiska samband kan separation av ammoniak och kvävgas via adsorption simuleras på en dator. Detta har stor potential till att skynda på samt vägleda utvecklingen för den adsorbörenhet som i slutändan ska kunna separera ren ammoniak i ett delsteg av en större process. Precis som med den större delen av forskning, kan utveckling av nya processer oAdsorption is an important separation technique in chemical engineering, capable of achieving a high purity of product. As it is also capable of concentrating even very low concentrations it was investigated as a possible method to concentrate the product of an ammonia plasma reactor in the EU DARE2X project. As the development of adsorption systems is expensive and time consuming, a simulation of

När HR granskar CV med AI

Denna studie syftar till att undersöka de sociologiska implikationerna som existerar kring Human Resources (HR) användning av Artificiell Intelligens (AI)-verktyg inom rekryteringsarbete. Studien har ett sociologiskt fokus i form av de teorier som appliceras på analysen av studiens resultat. Dessa teoretiska ramverk är institutionell teori, som används för att förklara hur organisatoriska trender The aim of this essay is to examine the implications that Human Resources (HR) usage of Artificiall Intelligence (AI) in recruiting processes have in relation to a sociological theoretical framework. The aim is to highlight both positive and negative aspects of this and discuss these factors in relation to sociological institutional theory as well as theory of symbolic interactionism. The topic of