Blood coagulation is essential for stopping bleeding but also drives thromboembolic disorders. Factor XII (FXII)-triggered coagulation promotes thrombosis while being dispensable for hemostasis, making it a potential anticoagulant target. However, its physiological role remains unclear. Here, we demonstrate that FXII-driven coagulation enhances innate immunity by trapping pathogens and restricting

Collagen VII is an essential anchoring protein in the basement membrane zone, maintaining the attachment of stratified and pseudostratified epithelia to the underlying interstitial matrix. However, collagen VII is largely unexplored in normal lungs and idiopathic pulmonary fibrosis (IPF), a disease characterized by excessive accumulation of extracellular matrix (ECM) and aberrant re-epithelializat

BACKGROUND: One of the critical challenges with capitation payment to primary care providers is ensuring that the fixed payments are equitable and adjusted for expected care needs. Patients of lower socioeconomic status (SES) generally have higher health care need. Sweden developed a Care Needs Index, which is used in the capitation payments to primary care providers to account for patient SES.OBJ

Objectives: Cystic fibrosis hepato-biliary involvement (CFHBI) is a common comorbidity in patients with CF and is associated with increased morbidity and mortality. The effect of the new and highly potent CF transmembrane conductance regulator modulator therapy, elexacaftor-tezacaftor-ivacaftor (ETI), on CFHBI, is still unclear. This study aimed to investigate the impact of ETI on liver stiffness

Serum Amyloid A (SAA) proteins are critical mediators of immune activation and metabolic regulation, bridging the acute-phase response with long-term disease dynamics. Once considered mere biomarkers of inflammation, emerging research has revealed their central role in orchestrating immune responses, lipid metabolism, and tissue remodeling. SAA proteins display context-dependent functions: they pr

Industrial and urban symbiosis (IUS) is an emerging sustainability strategy in which organizations collaborate to optimize resource flows and minimize waste within urban environments. Rooted in circular economy principles, IUS has gained global attention as cities seek innovative solutions to enhance resource efficiency and resilience. However, local authorities play a critical yet underexplored r

BACKGROUND: When plotting data points corresponding to the contrast-agent-induced change in transverse relaxation rate from a dynamic gradient-echo (GRE) magnetic resonance imaging (MRI) study versus a corresponding spin-echo study, a loop or vortex curve rather than a reversible line is formed. The vortex curve area is likely to reflect vessel architecture and oxygenation level. In this study, th

Persistent bacterial airway infection is a hallmark feature of cystic fibrosis (CF). Achromobacter spp. are gram-negative rods that can cause persistent airway infection in people with CF (pwCF), but the knowledge of host immune responses to these bacteria is limited. The aim of this study was to investigate if patients develop antibodies against Achromobacter xylosoxidans, the most common Achromo

BackgroundPresence of a prosthetic joint entails a life-long risk of haematogenous periprosthetic joint infection (hPJI) during bacteraemia. For bacteraemia with Staphylococcus aureus the hPJI frequency has been described to be up to 40% and for streptococci up to 20%, with large variation among reported frequencies.ObjectivesWe aimed to investigate the hPJI frequency from bacteraemia with virulen

We theoretically investigate a thermoelectric heat engine based on a single-level quantum dot, calculating average quantities such as current, heat current, output power, and efficiency, as well as fluctuations (noise). Our theory is based on a diagrammatic expansion of the memory kernel together with counting statistics, and we investigate the effects of strong interactions and next-to-leading or

MOTIVATION: Missing data present a pervasive challenge in data analysis, potentially biasing outcomes and undermining conclusions if not addressed properly. Missing data are commonly classified into Missing Completely at Random (MCAR), Missing at Random (MAR), and Missing Not at Random (MNAR). While MCAR poses a minimal risk of data distortion, both MAR and MNAR can seriously affect the results of

Känslan av mobilskärmen mot fingertoppen, klickljuden från kollegan som knappar på tangentbordet, skenet från en färgglad televisionsskärm som lyser upp vardagsrummets dunkel ... Den moderna människans tillvaro präglas av hens samspel med informationshanterande elektronik, och förbättringar inom informationsteknik är därmed av stor betydelse för en högre levnadsstandard. Ett sätt att förbättra kom[8]annulene units linked by alternating benzo[a,e]moieties are a promising new design for electro-responsive hydrocarbons. However, current methods for synthesizing benzo[8]annulenes limit the prospect of constructing longer multimers. In this work, an alternative synthesis route to the compound containing two [8]annulene moieties was pursued. The dimeric compound was ultimately furnished over thr

Nuclear fission leads to the splitting of a nucleus into two fragments1,2. Studying the distribution of the masses and charges of the fragments is essential for establishing the fission mechanisms and refining the theoretical models3,4. It has value for our understanding of r-process nucleosynthesis5,6, in which the fission of nuclei with extreme neutron-to-proton ratios is pivotal for determining

Vem är den unge kamraten? Vad finns kvar av det som en gång var en rörelse? Vad hände med alla storslagna drömmar om att förändra världen? Vad gör vi om vi redan förlorat och våra fiender sitter vid makten? Med föreställningarna Våld & pedagogik och Kropp & straff ville dramatikern Henrik Bromander och regissören John Hanse skapa nya lärostycken som tog sikte på samtidens akuta frågor. Ins

Contextual shifts are crucial for episodic memory, setting event boundaries during event segmentation. While lab research provides insights, it often lacks the complexity of real-world experiences. We addressed this gap by examining perceptual and conceptual boundaries using virtual reality (VR). Participants acted as salespeople, interacting with customers in a VR environment. Spatial boundaries

Memories link elements across event boundaries, integrating overlapping content experienced at different times and places. Such memory representations are thought to rely on memory integration mechanisms. The present study used multivariate pattern analysis (MVPA) of electroencephalographic (EEG) data to elucidate the temporal dynamics of integrative encoding memory processes. Memory integration w