Filtyp
Background: Glioblastoma, IDH wildtype is the most common primary malignant brain tumor in adults. Despite best available treatment, prognosis remains poor. Current standard therapy consists of surgical tumor removal followed by radiotherapy and chemotherapy with the alkylating agent temozolomide. Antisecretory factor (AF), an endogenous protein, may potentiate the effect of temozolomide and allev
Seagrass meadows are vital habitats, modifying hydrodynamic energy flows and sustaining biodiversity in the benthic environment. As such, there is a growing interest in using seagrass as a nature-based solution for coastal adaptation. However, planting seagrass in hydrodynamically exposed environments is challenging, and the trajectories and timescales of biodiversity recovery are not well studied
RATIONALE: Caffeine is commonly used in preterm infants to improve respiratory function. However, the optimal strategies for caffeine initiation have not been defined. OBJECTIVES: To evaluate the relative benefits and harms of different indications and timings for caffeine initiation in preterm infants. SEARCH METHODS: We searched MEDLINE, Embase, CENTRAL, and trial registries up to 23 April 2025.
Cervical screening frequency has not been studied in vaccinees. As the major risk factor, oncogenic human papillomavirus (HPV) is declining due to vaccination. We report a trial to assess the effectiveness of cervical screening frequency among women HPV-vaccinated as early adolescents (NCT02149030). In 2013, 5626 1992-1995-born women, who had received three doses of the HPV16/18 vaccine at ages 12
Objective: To describe the clinical and ultrasound characteristics at the time of diagnosis of primary ovarian immature teratoma with no other germ cell tumor components described on histopathology. Methods: This was a retrospective study of women with a histological diagnosis of primary ovarian immature teratoma who had undergone a preoperative ultrasound examination between 1998 and 2024. Cases
Introduction Lynch syndrome (LS) carriers have a 20-46% lifetime risk of colorectal cancer (CRC) due to mismatch repair gene variants. Mesalamine (5-ASA, 5-aminosalicylic acid), used safely in patients with ulcerative colitis, may reduce CRC risk in LS by decreasing microsatellite instability, a key driver of LS-related cancer. This study evaluates 5-ASA's efficacy as a tolerable chemopreventive d
Background: Hemophilia B is a genetic bleeding disorder caused by a deficiency of clotting factor IX, which presents unique challenges in clinical management. Advances in therapeutic strategies for hemophilia B have significantly improved patient outcomes but have also necessitated ongoing education for healthcare professionals. This illustrated review provides an overview of the challenges and op
Two new endemic species from Bolivia, Gomphrena vallegrandensis T. Ortuño & S. Lozada-Gobilard and Gomphrena palmariensis T. Ortuño, J. Gutiérrez. & Montesinos, are described and illustrated. The former only occurs in the native open natural grassland close to the Tucuman forest (Prov. Vallegrande), and the latter is restricted to the areas with rock outcrops in the subpuna close to the in
The circular economy constitutes a paradigm shift which has proven to be both engaging and unrealistic. While scholars and practitioners have started to advocate for a move toward the circular economy, promising a full reconfiguration of underlying practices and processes, many have become disillusioned about the lack of traction and progress. The circular economy transition has fallen between uto
The package ParSeq is a Python software library for Parallel execution of Sequential data analysis. It implements a general analysis framework that consists of transformation nodes - intermediate stops along the analysis propagation to visualize data, display status and provide user input - and transformations that connect the nodes. ParSeq imports data into an adjustable data model - a collection
Obesity represents a global health challenge, with a critical and urgent need for long-term, sustainable management strategies. Tirzepatide is a novel dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist. At first approved for the treatment of type 2 diabetes mellitus, tirzepatide represents one of the latest clinically approved and commercia
In this paper, we study the function spaces D(μ) by Richter (1991) and Aleman (1993), and Dμ→ by Rydhe (2019). It is known that the forward shift Mz is bounded and expansive on D(μ), and therefore D(μ) coincides with a de Branges-Rovnyak space H[B]. We show that such a B is rational if and only if μ is finitely atomic, and this happens exactly when the corresponding defect operator has finite rank
This study examined Poles’ acculturation preferences profiles toward two groups: people from Ukraine and the Middle East, and their relation to perceived cultural distance. The study framework emphasizes the juxtaposition of media and political narratives surrounding migrants arriving in Poland. Representative data from 924 participants was analysed. Regarding the preference toward individuals fro
Glioblastoma (GBM), the most aggressive brain tumor in adults, is characterized by its infiltrative growth along the perivascular space. Mural cells (MCs), encompassing pericytes and smooth muscle cells, are multifunctional perivascular cells implicated in GBM progression. MCs not only facilitate vascular co-option but have also been suggested to contribute to the immunosuppressive tumor microenvi
In packaging, the structural integrity of paperboard under complex stresses is essential. This study examines the delamination behavior of paperboard under normal and shear loading modes, which are the base for developing mixed-mode models. Four commercial paperboard grades, sourced from fibers across three geographical regions, are investigated using Double Cantilever Beam (DCB) and Split Double
