Context: Low birth weight (LBW) and unhealthy diets are risk factors of metabolic disease including type 2 diabetes (T2D). Genetic, nongenetic, and epigenetic data propose a role of the key metabolic regulator peroxisome proliferator-activated receptor gamma, coactivator 1alpha (PPARGC1A) in the development of T2D. Objective: Our objective was to investigate gene expression and DNA methylation of

The aim of this study was to identify factors associated with repeated suicide attempts among criminal justice clients examined for substance abuse using the Addiction Severity Index. Among suicide attempters (n = 1,404), repeaters (two or more attempts, n = 770) were compared to nonrepeaters. In logistic regression, repetition was associated with younger age, opioid analgesics, somatic medication

Endoleaks are one of the most common reasons for reinterventions and failure after endovascular aneurysm repair (EVAR). Current classifications divide endoleaks into type I-V but a more pragmatic definition is of direct and indirect endoleaks. Direct endoleaks (type I and III) transmit direct systemic pressure to the aneurysm sac and carry a high risk of aneurysm growth and rupture if left untreat

Understreckare skriven efter tsunamin i Thailand och orkanen Gudrun. Presenterar Jussi Hanska: "Strategies of Sanity and Survival: Religious Responses to Natural Disasters in the Middle Ages", Finnish Literature Society, 220 s, 2002

Current treatments that are efficient in controlling effector T cells responses to allografts have limited efficacy on the accelerated rejection mediated by memory T cells. Effective targeting of alloreactive memory T cells may therefore be explored to improve therapeutic approaches towards solving this problem. In this study, we investigated the synergistic effect of CD44/CD70 blockade and anti-C

Abstract is not available

Among the common complex diseases, hypertension has been particularly unlucky in the recent surge of positive results from genome-wide association studies. We summarize the evidence that would support continuing the effort in the hunt for a genetic basis for hypertension. The problems facing the genetic studies for hypertension are not unique, but phenotypic characterization, heterogeneity and hig

Det är en recension av en bok som handlar om omvandlingen av Köpenhamns elverk från kommunalt affärsverk till konkurrensutsatt bolag verksamt inom EU. En viktig aspekt är de anställdas anpassning till denna förändring.

The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Repeated dose toxicity was determined to have the most conservative systemic exp

Descriptive universalism

In modern Swedish, the word typ has a number of functions and meanings. Until about 1930, typ had, however, only a nominal function, and the other uses of typ have accordingly developed successively during the 20th century. In this article, which is based on a paper by Skärlund (2010), we track the grammaticalization of typ by utilizing electronic corpora, mainly comprising Swedish newspaper texts