Background: The optimal treatment for metastatic high-grade gastroenteropancreatic (GEP) neuroendocrine neoplasms when Ki-67 ≤55% is unknown. A prospective multi-centre phase 2 study was performed to evaluate the efficacy and safety of everolimus and temozolomide as first-line treatment for these patients. Methods: Patients received everolimus 10 mg daily continuously and temozolomide 150 mg/m2 fo

Using renewable fuels is a reliable approach for decarbonization of combustion engines. iso-Butanol and n-butanol are known as longer chain alcohols and have the potential of being used as gasoline substitute or a renewable fraction of gasoline. The combustion behavior of renewable fuels in modern combustion engines and advanced combustion concepts is not well understood yet. Low-temperature combu

Comparison of nestling diet between first and second broods of great tits Parus major in urban and forest habitats. To understand why early broods tend to be more successful than late broods we investigated the nestling diet and reproductive success of great tit pairs that had both a first and a second brood in the same breeding season. We found that in forest habitats great tit parents delivered

Oral assessment is an important method to evaluate the learning outcomes of scientific courses. However,there are certain limitations when oral assessment is applied.One of these limitations, which is not apparent in anonymous written exams, is the existence of biases which could lead to unfair (positive or negative) outcomes of the assessment. This could lead to decreased motivation and sense of

Jerome of Stridon has gone down in the history of Christianity as a fierce defender of what he considered to be orthodox teaching, and, in particular, as a convinced opponent of Origenism. However, this champion of orthodoxy often found himself suspected of relying on heretical writers, and a main purpose of his heresiological efforts was to defend himself against such accusations. The present stu

This article examines the heresiological mechanisms involved in constructing Origenism as a heresy in Late Antiquity. Attention is especially paid to the rhetorical role that “paganism” played in this construction. Focusing on the polemics of Jerome of Stridon, I argue that Jerome created a dichotomy of pagan learning and Christian confession, and described the Origenists as relying excessively on

När det gäller det tidiga klosterväsendet vet vi dessvärre mycket mer om manliga asketer och manliga kloster än om kvinnliga asketer och nunnekloster. Förutom en viss mängd papyrer, ostraka och annat arkeologiskt material är vi hänvisade till manliga författares skrifter om och till kvinnor. En av de manliga författare som bidragit allra mest när det gäller vår möjlighet att veta något om tidigkri

The modern study of Wilms tumour was prompted nearly 50 years ago, when Alfred Knudson proposed the ‘two-hit’ model of tumour development. Since then, the efforts of researchers worldwide have substantially expanded our knowledge of Wilms tumour biology, including major advances in genetics — from cloning the first Wilms tumour gene to high-throughput studies that have revealed the genetic landsca

We present the results from our investigation of angular correlations between baryons pairs in the Pythia8 event generator. We show how colour reconnection models and hadronization mechanisms influence such angular correlations and in particular address the effect of gluons on the baryon production mechanism in the Lund string fragmentation model. We conclude by discussing the new theoretical idea

We study a stochastic model of consensus formation, introduced in 2015 by Grinfeld, Volkov and Wade, who called it a multidimensional randomized Keynesian beauty contest. The model was generalized by Kennerberg and Volkov, who called their generalization the Jante's law process. We consider a version of the model where the space of possible opinions is a convex body B in Rd. N individuals in a pop

Background: Women are disproportionately affected by migraine, representing up to 75% of all migraine cases. This discrepancy has been proposed to be influenced by differences in hormone levels between the sexes. One such hormone is progesterone. Calcitonin gene-related peptide (CGRP) system is an important factor in migraine pathophysiology and could be influenced by circulating hormones. The pur

Artikeln bygger på en utvärdering som gjordes 2021-2022 när den brottspreventiva metoden SafeGrowth testades i området Drottninghög. Artikel utgår från ett polisperspektiv och visar på möjligheter med metoden, men också svårigheten att implementera en metod utvecklad i en specifik kontext, i andra miljöer.

Due to restrictions following the Covid-19 pandemic,major changes regarding teaching have been called for. Sincestudents’ presence in lab classrooms has been very restricted alsophysical labs have had to be transformed into e.g. simulationsperformed at home or via remote connections. After lifting of therestrictions, hybrid learning where both physical and simulatedlab environment are combined havDue to restrictions following the Covid-19 pandemic,major changes regarding teaching have been called for. Sincestudents’ presence in lab classrooms has been very restricted alsophysical labs have had to be transformed into e.g. simulationsperformed at home or via remote connections. After lifting of therestrictions, hybrid learning where both physical and simulatedlab environment are combined hav

This chapter addresses the ways in which the complexity of global governance enables or constrains political agency. An increasingly complex global institutional system—with its growing level of unpredictability and uncertainties—challenges some of the classical institutionalist tenets in respect of conditions of power and agency. For instance, the capacities of central governance institutions and

Background: It is currently unknown whether ultra-processed foods (UPFs) consumption is associated with a higher incidence of multimorbidity. We examined the relationship of total and subgroup consumption of UPFs with the risk of multimorbidity defined as the co-occurrence of at least two chronic diseases in an individual among first cancer at any site, cardiovascular disease, and type 2 diabetes.

IL-1, plays a role in some pathological inflammatory conditions. This pro-inflammatory cytokine also has a crucial role in tumorigenesis and immune responses in the tumor microenvironment (TME). IL-1 receptor accessory protein (IL-1RAP), combined with IL-1 receptor-1, provides a functional complex for binding and signaling. In addition to the direct role of IL-1, some studies demonstrated that IL1

Most research on the neurostructural basis of language abilities in children stems from small samples and surface-based measures. To complement and expand the existent knowledge, we investigated associations between grey matter volume and language performance in a large sample of 9-to-11-year-old children, using data from the Adolescent Brain Cognitive Development (ABCD) Study (N = 1865) and an al