The objective of the present paper was to provide an estimate of the benefits of on-demand and prophylaxis treatment strategies for severe haemophilia in monetary terms. Using the contingent-valuation method, which simulates a missing market by asking people about their willingness to pay (WTP), we asked a representative sample (n = 609) of the Swedish population if they would be willing to pay a

We have derived elemental abundances of O, Na, Mg, Al, Si, Ca, Ti, Cr, Mn, Fe, Co, Ni as well as for a number of s-elements for 47 G and K dwarf, with [Me/H]>0.1 dex. The selection of stars was based on their kinematics as well as on their uvby-beta photometry. One sample of stars on rather eccentric orbits traces the chemical evolution interior to the solar orbit and another, on circular orbits,

OBJECTIVE: To adapt the Knee injury and Osteoarthritis Outcome Score (KOOS) into French and to evaluate the psychometric properties of this new version. METHODS: The French version of the KOOS was developed according to cross-cultural guidelines by using the "translation-back translation" method to ensure content validity. KOOS data were then obtained in patients with symptomatic knee osteoarthrit

Lymphomas are currently categorized according to their origin from a B or T lymphocyte. Immature and less commonly mature (peripheral) lymphomas may harbor rearrangements of both the B- and T-cell antigen receptor genes (dual genotype or bigenotype). Rarely, cells in lymphoma with a single genotype simultaneously express both B- and T-cell markers (biphenotypic lymphomas). We discuss the diagnosti

Nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) were continuously delivered to the striatum at biologically active levels via recombinant adeno-associated viral (rAAV) gene transfer 4-5 weeks prior to 30 min of middle cerebral artery occlusion (MCAO). The magnitude of the deficits in a battery of behavioral tests designed to assess striatal function was highly correlated to

2(2-Hydroxyethyl)hydrazino-4-ethylamino-6-isopropylamino-s-triazine (HEATZ), a derivative of 2-chloro-4-ethylamino-6-isopropylamino-s-triazine, atrazine (ATZ) – a well known herbicide has been studied for complex formation with cobalt(II), nickel(II), and copper(II). Analytical, conductance, thermal, and spectral studies suggest that HEATZ is a monobasic NNO donor and it forms binuclear octahedral

Hypertension has been associated with raised plasma levels of complement factor 3 and 4 (C3 and C4). The nature of this association is unclear. This population-based longitudinal study explored whether C3 or C4 is associated with development of hypertension. Blood pressure and plasma levels of C3 and C4 were determined in 2178 healthy men, aged 35-50 years, initially without treatment for hyperten

A few tens of millions of years after the intrusion of the Early Svecofennian (similar to1.87-1.85 Ma) granitoids in central Sweden, a renewed magmatic activity resulted in the emplacement of the Late Svecofennian granites, the tectonic setting of which remains obscure. S-type granites dominate this group, but both I-type and transitional granites are common. This study deals with one of these int

The glpTQ operon of Haemophilus influenzae type b (Hib) and nontypeable H. influenzae (NTHi) strains is highly conserved, except for a 1.4-kb glpTQ intergenic region that was found in most Hib strains. The presence of this intergenic region results in divergent glpTQ transcriptional profiles for Hib and NTHi where Hib strains appear to have evolved an alternative promoter for glpQ expression. Base

Predicted flight trajectories differ depending on which orientation cues are used by migrating birds. Results from radar and satellite tracking of migrating birds can be used to test which of the predicted trajectories shows the best fit with observed flight routes, supporting the use of the associated orientation mechanism. Radar studies of bird migration at the Northeast Passage and the Northwes

This study focuses on the hygroscopic properties of submicrometer aerosol particles emitted from two small-scale district heating combustion plants (1 and 1.5 MW) burning two types of biomass fuels (moist forest residue and pellets). The hygroscopic particle diameter growth factor (Gf) was measured when taken from a dehydrated to a humidified state for particle diameters between 30 350 nm (dry siz

Objective: Dominant mutations in the three collagen VI genes cause Bethlem myopathy, a disorder characterized by proximal muscle weakness and commonly contractures of the fingers, wrists, and ankles. Although more than 20 different dominant mutations have been identified in Bethlem myopathy patients, the biosynthetic consequences of only a subset of these have been studied, and in many cases, the

We investigate steady symmetric gravity water waves on finite depth. For nonpositive vorticity it is shown that the particles display a mean forward drift, and for a class of waves we prove that the size of this drift is strictly increasing from bottom to surface. This includes the case of particles within irrotational waves. We also provide detailed information concerning the streamlines and the

The aim of the study was to determine how significance indicators assigned to different Web page elements (internal metadata, title, headings, and main text) influence automated classification. The data collection that was used comprised 1000 Web pages in engineering, to which Engineering Information classes had been manually assigned. The significance indicators were derived using several differe

The Sahel region of Africa has experienced a decrease in rainfall from the early 1960s to mid 1990s. Recent studies have detected an increased in NDVI amplitude and growing season integrated NDVI for the region since 1982. However, these studies have not examined how plant phenology has changed. Phenology examines life cycle events such as bud burst and leaf senescence. Using the software TIMESAT

A new laser technique for detecting the air/fuel mixture in the combustion process is presented as a method for improving cycle-by-cycle variations in an HCCI engine.

Using toy model, we examine the propagation of excitons in Cu2O, which form localized pulses under certain experimental conditions. The formation of these waves is attributed to the effect of dispersion, non-linearity and the coupling of the excitons to phonons, which acts as dissipative mechanism.