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Evidence for dysfunction of the nigrostriatal pathway in the R6/1 line of transgenic Huntington's disease mice

Petersén Å, Puschban Z, Lotharius J, NicNiocaill B, Wiekop B, O´Connor, WT and Brundin P.Neurobiology of Disease 11: 134-146 (2002)AbstractThe present multidisciplinary study examined nigrostriatal dopamine and striatal amino acid transmission in the R6/1 line of transgenic Huntington's disease (HD) mice expressing exon 1 of the HD gene with 115 CAG repeats. Although the number of tyrosine hydroxy

https://www.huntington-research.lu.se/evidence-dysfunction-nigrostriatal-pathway-r61-line-transgenic-huntingtons-disease-mice - 2025-06-07

Maintenance of susceptibility to neurodegeneration following intrastriatal injections of quinolinic acid in a new transgenic mouse model of Huntington's disease

Petersén Å, Chase K, Puschban Z, DiFiglia M, Brundin P and Aronin N.Experimental Neurology 175: 297-300 (2002)AbstractA transgenic mouse model of Huntington's disease (R6/1 and R6/2 lines) expressing exon 1 of the HD gene with 115-150 CAG repeats resisted striatal damage following injection of quinolinic acid and other neurotoxins. We examined whether excitotoxin resistance characterizes mice with

https://www.huntington-research.lu.se/maintenance-susceptibility-neurodegeneration-following-intrastriatal-injections-quinolinic-acid-new - 2025-06-07

Huntington's Disease: the mystery unfolds?

Petersén Å and Brundin P.International Review of Neurobiology 53: 315-339 (2002) SummaryThe Huntington's disease (HD) has stimulated novel clinical drug trials based on the ideas about mechanisms of cell death in the disorder. A recent study investigated the effects of remacemide and coenzyme Q on progression of symptoms in HD. These drugs are an N-methyl-d-aspartate (NMDA) antagonist and a mitoch

https://www.huntington-research.lu.se/huntingtons-disease-mystery-unfolds - 2025-06-07

Mice transgenic for exon 1 of the Huntington's disease gene display reduced striatal sensitivity to neurotoxicity induced by dopamine and 6-hydroxydopamine

Petersén Å, Hansson O, Puschban Z, Sapp E, Romero N, Castilho RF, Sulzer D, Rice M, DiFiglia M, Przedborski S and Brundin P.European Journal of Neuroscience 14: 1-13 (2001)AbstractHuntington's disease is an autosomal dominant hereditary neurodegenerative disorder characterized by severe striatal cell loss. Dopamine (DA) has been suggested to play a role in the pathogenesis of the disease. We have

https://www.huntington-research.lu.se/mice-transgenic-exon-1-huntingtons-disease-gene-display-reduced-striatal-sensitivity-neurotoxicity - 2025-06-07

Expanded CAG repeats in exon 1 of the Huntington's Disease gene stimulate dopamine-mediated striatal neuron autophagy and degeneration

Petersén Å, Larsen KE, Behr GG, Romero N, Przedborski S, Brundin P and Sulzer D.Human Molecular Genetics 10: 1243-1254 (2001)AbstractHuntington's disease (HD) is caused by an expanded CAG repeat in exon 1 of the gene coding for the huntingtin protein. The cellular pathway by which this mutation induces HD remains unknown, although alterations in protein degradation are involved. To study intrinsic

https://www.huntington-research.lu.se/expanded-cag-repeats-exon-1-huntingtons-disease-gene-stimulate-dopamine-mediated-striatal-neuron - 2025-06-07

Brain-derived neurotrophic factor inhibits apoptosis and dopamine-induced free radical production in striatal neurons but does not prevent cell death

Petersén Å, Larsen KE, Behr GG, Romero N, Przedborski S, Brundin P, and Sulzer D.Section for Neuronal Survival, Wallenberg Neuroscience Center, Lund University, Lund, SwedenBrain Research Bulletin 56(3-4): 331-335 (2001)AbstractIn hereditary Huntington's disease, a triplet repeat disease, there is extensive loss of striatal neurons. It has been shown that brain-derived neurotrophic factor (BDNF) p

https://www.huntington-research.lu.se/brain-derived-neurotrophic-factor-inhibits-apoptosis-and-dopamine-induced-free-radical-production - 2025-06-07

Digital Methods

20 and 21 March 2024. Two-day workshop at Centre for East and South-East Asian Studies, Lund University Digital sources and methods are of increasing interest to Asian Studies researchers, but how can we best use these methods? Join us at the Centre for a two-day workshop on digital methods in Asian Studies organised by the Graduate School in Asian Studies. The workshop, envisioned as a meeting be

https://www.graduateschoolasianstudies.lu.se/activities/workshops/previous-workshops/digital-methods - 2025-06-07

Presentation Skills and Public Speaking

22 May, Stadshallen Lund At this workshop, led by Altitude Meetings, and co-organised with the Graduate School in History, you will get practical advice in a workshop format on how to become a better speaker. The workshop includes an inspiration lecture, advice on what is a good presentation, tips on body language and how to manage nervousness etc. The workshop also includes some practical exercis

https://www.graduateschoolasianstudies.lu.se/activities/workshops/presentation-skills-and-public-speaking - 2025-06-07

Contact us

People Lund office Programme Committee Advisory Board PhD students Postal address Lund University Graduate School in Asian Studies Centre for East and South-East Asian Studies P.O Box 118 SE- 221 00 Lund Sweden Visiting and delivery address Sölvegatan 18 B 223 62 Lund Sweden Google map  

https://www.graduateschoolasianstudies.lu.se/contact-us - 2025-06-07

Organization

The Graduate School in Asian Studies is coordinated and administered by the Centre for East and South-East Asian Studies at Lund University. It has a programme committee consisting of representatives from the different Swedish partner institutions who are involved in the planning and oversight of the school’s activities.  The graduate school also has an international advisory board with representa

https://www.graduateschoolasianstudies.lu.se/graduate-school-asian-studies/organization - 2025-06-07

PhD workshop on International Relations

The Graduate School in Asian Studies in cooperation with Horizon Europe EUVIP project (EU in the Volatile Indo-Pacific) invite you to apply for our PhD workshop on International Relations. The workshop will bring together PhD students and senior scholars working on Asian International Relations over two days here at the Centre for East and Southeast Asian Studies, to discuss key issues in the regi

https://www.graduateschoolasianstudies.lu.se/activities/workshops/phd-workshop-international-relations - 2025-06-07

Podcast Production Workshop

As a partner for the Nordic Asia Podcast, the Centre/Graduate School is organizing a Podcast Production Workshop to provide practical training for participants to embark on the exciting journey into the world of podcasting. PhD candidate Joanne Kuai is an experienced journalist and podcaster producer and will be the instructor of the workshop. The venue will be the Centre for East and South-East A

https://www.graduateschoolasianstudies.lu.se/activities/workshops/previous-workshops/podcast-production-workshop - 2025-06-07