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Making Manufacturing Flexibility Operational Part 2 - Distinctions and an Example

Structures the concept of flexibility by making clear distinctions in three generic dimensions, describes the use of the framework for manufacturing flexibility by working through a concrete example. The framework was presented in “Making manufacturing flexibility operational – part 1: a framework”, IMS, Vol. 6 No. 2. Makes distinctions between the concept of flexibility in the three generic dimen

Neural grafting to experimental neocortical infarcts improves behavioral outcome and reduces thalamic atrophy in rats housed in enriched but not in standard environments

BACKGROUND AND PURPOSE: The purpose of this study was to evaluate whether grafting of fetal neocortical tissue 1 week after focal brain ischemia improved behavioral outcome and reduced secondary thalamic atrophy. METHODS: One week after distal ligation of the right middle cerebral artery in spontaneously hypertensive male rats, blocks of fetal neocortex (embryonic day 17) were homografted to rats

In Defense of Obesity

Previous research suggests that an inclination to eat in response to unlabeled anxiety and a strong dependence on environmental stimuli are more common in overweight individuals than in normal-weight controls. In particular, individuals who habitually use food and eating in order to alleviate painful feelings have to face these feelings when dieting, unless they can be neutralised by psychological

Selective electrical stimulation of postganglionic cerebrovascular parasympathetic nerve fibers originating from the sphenopalatine ganglion enhances cortical blood flow in the rat

Recently, the origins and pathways of cerebrovascular acetylcholine- and vasoactive intestinal polypeptide-containing nerves have been elucidated in detail in the rat: The sphenopalatine ganglion is the major source for postganglionic parasympathetic fibers to the vascular beds of the cerebral hemispheres. To clarify the functional role of the nerves on cerebral blood vessels in vivo, brain cortic

T-lymphocyte-epithelial-cell interactions: integrin alpha(E)(CD103)beta(7), LEEP-CAM and chemokines

The epithelia are the avascular layers of cells that cover the environment-exposed surfaces of the body. It appears that T cells localize to selected sites in or adjacent to epithelia via the selective expression of adhesion molecules and chemokine receptors on T cells. These bind to counter-receptors and to chemokines expressed by epithelial cells. Recently, there has been an advance in our under

A simple visual system without neurons in jellyfish larvae

Earlier detailed studies of cnidarian planula larvae have revealed a simple nervous system but no eyes or identifiable light sensing structures. Here, we describe the planula of a box jellyfish, Tripedalia cystophora, and report that these larvae have an extremely simple organization with no nervous system at all. Their only advanced feature is the presence of 10-15 pigment-cup ocelli, evenly spac

Thermopower anomaly in multiple barrier structures

We have predicted that in suitable multiple barrier structures without applied bias, the thermopower may change sign because of quantum transport process. We have performed detailed numerical calculation to show that the predicted thermopower anomaly can be experimentally observed. This thermopower anomaly does not violate thermodynamic laws.

The SLC6A14 gene shows evidence of association with obesity

In our previous genome-wide scan of Finnish nuclear families, obesity was linked to chromosome Xq24. Here we analyzed this 15-Mb region by genotyping 9 microsatellite markers and 36 single nucleotide polyp morphisms (SNPs) for 11 positional and functional candidate genes in an extended sample of 218 obese Finnish sibling pairs (sibpairs) (BMI > 30 kg/m(2)). Evidence of linkage emerged mainly from

The Evolution of Life Histories in Holo-anhydrobiotic Animals: A First Approach

The life histories of holo-anhydrobiotic animals differ from those of all other organisms by a regular or irregular entrance into an ametabolic state induced by desiccation. Such ametabolic periods will arrest growth and reproduction completely and thus affect primary life history parameters dramatically. The selective forces and the genetic and physiological trade-offs acting on anhydrobiotic ani

Some Integral Formulas for Fatigue Damage in Variable Amplitude Loading

In this paper some integral formulas for the fatigue damage in variable amplitude loading are presented. The formulas, which in their original form appeared in Rychlik (1993), may be used for both the theoretical analysis of the fatigue damage, resulting from different cycle counting algorithms, as well as for the computation of different statistical properties of the fatigue damage.

Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes.

Genetic variants in the gene encoding for transcription factor-7-like 2 (TCF7L2) have been associated with type 2 diabetes (T2D) and impaired beta cell function, but the mechanisms have remained unknown. We therefore studied prospectively the ability of common variants in TCF7L2 to predict future T2D and explored the mechanisms by which they would do this. Scandinavian subjects followed for up to