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SIRT1 is increased in affected brain regions and hypothalamic metabolic pathways are altered in Huntington disease

Baldo B, Gabery S, Soylu-Kucharz R, Cheong RY, Henningsen JB, Englund E, McLean C, Kirik D, Halliday G and Petersén Å.Neuropathology and Applied Neurobiology 45 (4): 361-379 (2019)AbstractAIMS:Metabolic dysfunction is involved in modulating the disease process in Huntington disease (HD) but the underlying mechanisms are not known. The aim of this study was to investigate if the metabolic regulator

https://www.huntington-research.lu.se/sirt1-increased-affected-brain-regions-and-hypothalamic-metabolic-pathways-are-altered-huntington - 2025-07-07

Huntingtin Aggregation Impairs Autophagy, Leading to Argonaute-2 Accumulation and Global MicroRNA Dysregulation

Pircs K, Petri R, Madsen S, Brattås PL, Vuono R, Ottosson DR, St-Amour I, Hersbach BA, Matusiak-Brückner M, Lundh SH, Petersén Å, Déglon N, Hébert SS, Parmar M, Barker RA and Jakobsson J.Cell Reports 24(6): 1397-1406 (2018)AbstractMany neurodegenerative diseases are characterized by the presence of intracellular protein aggregates, resulting in alterations in autophagy. However, the consequences o

https://www.huntington-research.lu.se/huntingtin-aggregation-impairs-autophagy-leading-argonaute-2-accumulation-and-global-microrna - 2025-07-07

Microstructural white matter alterations and hippocampal volumes are associated with cognitive deficits in craniopharyngioma

Fjalldal S, Follin C, Svärd D, Rylander L, Gabery S, Petersen Å, Van Westen D, Sundgren P, Bjorkman-Burtscher I, Lätt J, Ekman B, Johanson A and Erfurth EM.European Journal of Endocrinology 178 (6): 577-587 (2018)AbstractCONTEXT:Patients with craniopharyngioma (CP) and hypothalamic lesions (HL) have cognitive deficits. Which neural pathways are affected is unknown.OBJECTIVE:To determine whether th

https://www.huntington-research.lu.se/microstructural-white-matter-alterations-and-hippocampal-volumes-are-associated-cognitive-deficits - 2025-07-07

Laminin α1 reduces muscular dystrophy in dy2J mice

Gawlik KI1, Harandi VM2, Cheong RY3, Petersén Å3, Durbeej M2.1Muscle Biology Unit, Department of Experimental Medical Science, Lund University, Lund, Sweden.2Muscle Biology Unit, Department of Experimental Medical Science, Lund University, Lund, Sweden.3Translational Neuroendocrine Research Unit, Department of Experimental Medical Science, Lund University, Lund, Sweden.Matrix Biology 70: 36-79 (20

https://www.huntington-research.lu.se/laminin-a1-reduces-muscular-dystrophy-dy2j-mice - 2025-07-07

Hypothalamic Alterations in Neurodegenerative Diseases and Their Relation to Abnormal Energy Metabolism

Vercruysse P, Vieau D, Blum D, Petersén Å and Dupuis L.Frontiers in Molecular Neuroscience 11:2 (2018)AbstractNeurodegenerative diseases (NDDs) are disorders characterized by progressive deterioration of brain structure and function. Selective neuronal populations are affected leading to symptoms which are prominently motor in amyotrophic lateral sclerosis (ALS) or Huntington's disease (HD), or co

https://www.huntington-research.lu.se/hypothalamic-alterations-neurodegenerative-diseases-and-their-relation-abnormal-energy-metabolism - 2025-07-07

Funding

Please note, that all links on this page open a new webpage. Knut and Alice Wallenberg Foundation Through the research program Wallenberg Clinical Scholars, the Knut and Alice Wallenberg Foundation are funding 24 of the foremost clinical researchers in Sweden. Almost SEK 800 million are used for funding over ten years. Åsa Petersén was appointed Wallenberg Clinical Scholar 2020 and will receive SE

https://www.huntington-research.lu.se/funding - 2025-07-07

Political Science: Ontological Security Studies

Congratulations and welcome to the course STVN20! We are happy to welcome you to the Department of Political Science at Lund University. In order to accept and secure our offer please read the information below carefully. Secure your place Do not forget to accept our offer before July 18 midnight (Swedish time)! If you miss to reply by this date, the offer will be revoked.Accept our offer by loggi

https://www.svet.lu.se/en/education/new-student-admission-information/political-science-ontological-security-studies - 2025-07-07

Political Science: The Politics of Development

Congratulations and welcome to the course STVC02 We are happy to welcome you to the Department of Political Science at Lund University. In order to accept and secure our offer please read the information below carefully. Secure your place Do not forget to accept our offer before July 18 midnight (Swedish time)! If you miss to reply by this date, the offer will be revoked.Accept our offer by loggin

https://www.svet.lu.se/en/education/new-student-admission-information/political-science-politics-development - 2025-07-07

Political Science: International Political Economy and Development

Congratulations and welcome to the course STVC05 We are happy to welcome you to the Department of Political Science at Lund University. In order to accept and secure our offer please read the information below carefully. Secure your place Do not forget to accept our offer before July 18 midnight (Swedish time)! If you miss to reply by this date, the offer will be revoked.Accept our offer by loggin

https://www.svet.lu.se/en/education/new-student-admission-information/political-science-international-political-economy-and-development - 2025-07-07

European Union research group

Understanding European Union multilevel politics from the local to the state, supranational, and planetary levels On this page, the European Union research group (EURG) is presented, including the conveners, researchers in the group, selected publications, and related education. We have restarted the European Union research group!European politics is more important than ever. Therefore, we are exc

https://www.svet.lu.se/en/research/research-groups/european-union-research-group - 2025-07-07

Peace in the 21st Century: Critical Debates on Violence, Justice, and Peace

FKVC35 – Peace in the 21st Century: Critical Debates on Violence, Justice, and Peace (7.5 credits). Bachelor course in Peace and Conflict Studies. Spring term. What is the relationship between peace and justice? How are different types of violence related to struggles for peace? How do we envision peace in the 21st century? Much of peace and conflict studies centres around peace in relation to vio

https://www.svet.lu.se/en/education/international-opportunities/exchange-students-coming-sweden/bachelor-courses/peace-21st-century-critical-debates-violence-justice-and-peace - 2025-07-07

International Criminal Justice: When Law meets Politics

FKVC36 – International Criminal Justice: When Law meets Politics (7.5 credits). Bachelor course in Peace and Conflict Studies. Spring term. The course offers a critical reading of the work undertaken by all international criminal courts and tribunals. Throughout the course you will study basic tenants of Criminal Justice and their application at the international level to discover the fragility of

https://www.svet.lu.se/en/education/international-opportunities/exchange-students-coming-sweden/bachelor-courses/international-criminal-justice-when-law-meets-politics - 2025-07-07

Kontakt

Behöver du kontakta din forskningssjuksköterska?  Mottagningen i MalmöMaria Hyllengren : 040-39 19 12 (SINT1A, GRAIN, AVAnT1A, ASTR1D uppföljning)Sofie Alström Mortin: 040-39 19 10 (ASTR1D, SINT1A, AVAnT1A, iT1D) Terese Gudmundsson: 040-39 19 11 (PreCiSe, GRaIn, IDAC)Jessica Melin: 040-39 19 09 (iT1D)Mottagningen i HelsingborgSusanne Hyberg: 042 -406 39 27 (PreCiSe, GRaIn)Terese Wiktorsson 042-406

https://www.gppad.lu.se/kontakt - 2025-07-07

Om GPPAD

Den Globala Plattformen för Prevention av Autoimmun Diabetes (GPPAD) initierades år 2015. GPPAD är ett nätverk bestående av forskare, professionella och akademiska institutioner och har studiecentran i fem europeiska länder, Belgien, Tyskland, Polen, Storbritannien och Sverige. Tillsammans skapar vi en internationell infrastruktur för primärpreventiva studier avseende typ 1-diabetes.Dessa studier

https://www.gppad.lu.se/om-gppad - 2025-07-07

SINT1A

Supplementation with B. INfantis for Mitigation of Type 1 Diabetes Autoimmunity Nu är studien fullrekryterad, februari 2024. Vad är SINT1A-studien? SINT1A-studien (Supplementation with B. INfantis for Mitigation of Type 1 Diabetes Autoimmunity) är en vetenskaplig studie för spädbarn med ökad risk för typ 1-diabetes. Spädbarn upp till sex veckors ålder kan inkluderas i studien. Målet med studien är

https://www.gppad.lu.se/vara-studier/sint1a - 2025-07-07

Forskning om celiaki

Mer gluten ökar risk för celiakiöppnas i nytt fönsterArtikel med Carin Andrén Aronsson (hd.se)                                                                                                                                                                                                                                                                                                     Nya rön: Mäng

https://www.gppad.lu.se/vara-studier/precise/forskning-om-celiaki - 2025-07-07

Vad är celiaki?

Celiaki - glutenintolerans Celiaki, som även kallas för glutenintolerans, är en kronisk sjukdom som orsakas av överkänslighet mot gluten. Denna överkänslighet leder till skador på slemhinnan i tarmen som i sin tur leder till att kroppen inte kan ta upp näringen i maten på ett normalt sätt. Celiaki är en autoimmun sjukdom, precis som typ 1-diabetes, och man tror att både genetiska och miljöfaktorer

https://www.gppad.lu.se/fragor-och-svar/vad-ar-celiaki - 2025-07-07

Om besöken

Detta händer vid besöken i POInT-studien Besök 1 till 8 ingår i interventionsfasen, besök 9-16 i uppföljningsfasen. Interventionsfasen:Besök 1 (Baseline)Ålder: 4-7 månaderVägningMätningTa första kapselnBlodprovstagning och kapillärt blodsocker efter 30, 60 och 120 minuter efter intag av kapseln.Besök 2Ålder: 6-9 månaderVägningMätningKapseln tas på mottagningenBlodprovstagning och kapillärt blodsoc

https://www.gppad.lu.se/vara-studier/point/om-besoken - 2025-07-07

POInT

Primär oral insulinterapi (Primary Oral Insulin Trial) POInT-studien är avslutad och nu följer väntan på att koden ska knäckas om vilka som fått placebo och vilka som fått oralt insulin och om det haft någon effekt. Förhoppningsvis får deltagarna reda på det till hösten 2025. Informationen kommer att ges till alla familjer som deltagit innan resultatet från studien officiellt publiceras. I POInT u

https://www.gppad.lu.se/vara-studier/avslutade-studier/point - 2025-07-07