Tyrosine kinase inhibitors targeting the BCR-ABL oncoprotein in chronic myeloid leukemia (CML) are remarkably effective inducing deep molecular remission in most patients. However, they are less effective to eradicate the leukemic stem cells (LSC), resulting in disease persistence. Therefore, there is great need to develop novel therapeutic strategies to specifically target the LSC. In an experime

Student engagement is an important factor when it comes to the learning process. Students who do not feel engaged in their studies are more likely to fail their exams and might even drop out of their education. Different methods have been tried in order to increase student engagement. One of them is the contributing student pedagogy, where students contribute to the learning of others and also val

In sensor network applications with low traffic intensity, idle channel listening is one of the main sources of energy waste. The use of a dedicated low-power wake-up receiver (WRx), which utilizes duty-cycled channel listening, can significantly reduce the idle listening energy cost. Extreme low-power design typically leads to performance losses, indirectly increasing energy costs. Striking the r

When is the Charter of Fundamental Rights of the EU applicable to a Member State measure? In C-446/12 – 449/12 Willems the CJEU held that a Member State which stores and uses fingerprint data, originally collected in compliance with Regulation No 2252/2004, but which the Member State then uses for purposes other than those stipulated in the Regulation, is not acting within the scope of EU law, and

Lactones, cyclic esters of hydroxycarboxylic acids, are interesting biofuel candidates as they can be made from cellulosic biomass and have favorable physical and chemical properties for distribution and use. The reactions of γ-valerolactone (GVL), γ-crotonolactone (2(5H)-F), and α-methyl-γ-crotonolactone (3M-2(5H)-F) with Cl, OD, and O3 were investigated in a static chamber at 700 Torr and 298 ±

The distributions of transverse momentum and longitudinal momentum fraction of charged particles in jets are measured in Pb+Pb and pp collisions with the ATLAS detector at the LHC. The distributions are measured as a function of jet transverse momentum and rapidity. The analysis utilises an integrated luminosity of 0.14 nb- 1 of Pb+Pb data and 4.0 pb- 1 of pp data collected in 2011 and 2013, respe

Eggs of sterlet are discharged outside into ambient aquatic environment where egg activation and fertilization occur. Effects of different activation media including freshwater and clay suspension on protein abundances of egg were quantified in sterlet Acipenser ruthenus. In-gel digestion and high resolution mass spectrometry were used for label-free protein quantification in the eggs of five fema

In the current research, effects of the layout of film holes near the first-stage vane leading edge on the endwall cooling and phantom cooling of the vane suction side surface were numerically studied. The computational results indicate that the case with a positive film-hole angle achieves a higher cooling effectiveness level on the endwall and vane suction side surface compared to the case with

Air film cooling is a conventional cooling technique that has been successfully used for gas turbine hot-section components, such as combustor liners, combustor transition pieces, and turbine vanes and blades. However, the increased benefit seems to approach a limit. This paper investigates the film cooling effectiveness considering mist injection. All the studies for various boundary conditions a

The screening of plate-plate interactions by counterions is an age-old problem. We revisit this classic question when counterions exhibit a distribution of charges. While it is expected that the long-distance regime of interactions is universal, the behaviour of the inter-plate pressure at smaller distances should a priori depend rather severely on the nature of the ionic mixture screening the pla

Valves are widely used for fluid flow control, not only for conventional fluid like water, gas and oil, but also for hydrogen under high pressure and so forth. Under these new conditions, the response time and energy consumption of valves are closely related to the whole performance of the piping system. Pilot-control globe valve (PCGV) is a novel quick response valve, which can utilize the pressu

Background: The recent genome-wide association studies (GWAS) of Type 2 Diabetes (T2D) have identified the pancreatic β-cell as the culprit in the pathogenesis of the disease. Mitochondrial metabolism plays a crucial role in the processes controlling release of insulin and β-cell mass. This notion implies that mechanisms controlling mitochondrial function have the potential to play a decisive path

Laminar methane/air premixed Bunsen flames were studied using detailed numerical simulations and laser diagnostics. In the numerical simulations one-dimensional and two-dimensional configurations were considered with detailed transport properties and chemical kinetic mechanism. In the measurements OH PLIF was employed. The flame structures vary with varying equivalence ratio and pressure. For stoi

BACKGROUND AND OBJECTIVES: To study selective regional binding for tau pathology in vivo, using PET with [(11) C]PBB3 in PSP patients, and other conditions not typically associated with tauopathy.METHODS: Dynamic PET scans were obtained for 70 minutes after the bolus injection of [(11) C]PBB3 in 5 PSP subjects, 1 subject with DCTN1 mutation and PSP phenotype, 3 asymptomatic SNCA duplication carrie