Background: Cardiac allograft vasculopathy is characterized by increased coronary intimal thickness and is a leading cause of death in heart transplant (HTx) recipients despite the routine use of statins. The experience with inhibitors of proprotein convertase subtilisin-kexin type 9 in HTx recipients is limited. Our hypothesis was that lowering cholesterol with the proprotein convertase subtilisi

The possibilities of generative artificial intelligence (GenAI) are both exciting and potentially concerning in many aspects of higher education. One concern may be that the increased use of GenAI tools exacerbates and perpetuates structural inequities due to the material used to train these tools, counteracting efforts to build inclusive learning communities. In this chapter, we consider how univ

Protein dynamics are essential to biological function, and methods to determine such structural rearrangements constitute a frontier in structural biology. Synchrotron radiation can track real-time protein dynamics, but accessibility to dedicated high-flux single X-ray pulse time-resolved beamlines is scarce and protein targets amendable to such characterization are limited. These limitations can

Objective: To assess the 5-year effects of arthroscopic partial meniscectomy (APM) vs. placebo surgery on the development of the structural changes of the knee by magnetic resonance imaging (MRI). Design: This multicentre, randomized, participant- and outcome-assessor-blinded, placebo-surgery-controlled trial was carried out in Finland. We randomized 146 adults, mean age 52 years (range 35 to 65)

In this paper, the local bonding structure in amorphous zinc tin oxide (a-ZTO) is probed using a combination of XANES and EXAFS techniques at the Zn and Sn K-edges to gain insight into charge carrier generation in the material. a-ZTO is prepared using two growth methods; spray pyrolysis and magnetron sputtering. It is seen that a-ZTO grown by magnetron sputtering shows no changes in the chemical e

Residents of the Sahel depend on livestock, but harsh environmental conditions during the dry season limit rangeland forage, which is the main source of livestock feed. Al-though operational tools exist for assessing and monitoring forage quantity during the dry season, assessments of forage quality are lacking. We addressed this gap by developing satellite-based monitoring of forage quality acros

Background: Data on the outcomes of COVID-19 in people living with HIV (PLHIV), specifically in relation to vaccination status, are lacking during the Omicron era. Methods: This nationwide registry-based study included all resident in Sweden ≥18 years with a positive SARS-CoV-2 PCR test during January 2021–February 2023. We estimated adjusted odds ratios (adjOR) for COVID-19 hospitalisation and se

The Peruvian specimens of the family Cerambycidae Latreille, 1802 (Coleoptera) housed in the Biological Museum at Lund University in Sweden are cataloged and illustrated. Photographs of dorsal habitus, labels, and complete label data of all the specimens are provided. There are 81 specimens belonging to 38 species, 29 genera, three subfamilies, and 19 tribes. Anisopodus ligneus Bates, 1863 is a ne

Purpose: We aimed to analyze the risk of hereditary hemochromatosis (HH) among first-generation and second-generation immigrants in Sweden using Swedish-born individuals and Swedish-born individuals with Swedish-born parents as referents, respectively. Methods: All individuals aged 18 years of age and older, n = 6,180,500 in the first-generation study, and n = 4,589,930 in the second-generation st

In this paper, we unify two already published results on state feedback H-infinity optimality. Previously, optimality has been shown for a particular controller structure in the case that the open-loop state matrix is symmetric, as well as in the case that the closed-loop system is internally positive. By contrast, the main result of the present paper gives optimality based on neither of these two

Both pain and mental health conditions are common among young people. They often co-occur, but we wanted to investigate further whether it is pain (abdominal pain, headache, musculoskeletal pain, menstrual pain) that precedes mental health conditions (depression, anxiety, stress, phobia) or whether it is the other way around, mental health conditions that precede pain. Using electronic health reco

Background Percutaneous coronary intervention (PCI) is frequently used for patients with chronic coronary syndrome (CCS). However, the role of PCI beyond symptom relief in CCS remains controversial. The objective of this study was to determine whether PCI is associated with better outcomes, compared with medical therapy (MT) alone. Methods We conducted a retrospective cohort study. Using the Swedi

This study employs computational algorithms to automatically identify and classify features in X-Ray fluorescence (XRF) microscopy images. Principal component analysis (PCA) and unsupervised machine learning algorithms, such as Gaussian mixture (GM) clustering, are implemented to label features on a collection of XRF maps of human atherosclerotic plaque samples. The investigation involves the hard

Based on self-determination theory, this research relied on person-centered analyses to show how the distinct components of psychological need states combine to produce distinct profiles. We also explored contemporarily antecedents (perceptions of the organization's environmental corporate social responsibility and negative moral emotions related to the organization's environmental (ir)responsibil

Background: Positron emission tomography (PET) response criteria in solid tumours (PERCIST 1.0) is a systematic assessment of therapy response with fluorine 18 fluorodeoxyglucose ([18F]FDG) PET. The ordered subset expectation maximization (OSEM) and block sequential regularized expectation maximization (BSREM) reconstruction algorithms are both commonly used. The impact of using OSEM or BSREM on P

In 2014, Christian List and I published a paper that delineated our view regarding what it takes for an agent to act freely. We suggested that this requires the action to be endorsed by the agent and caused by this endorsement and yet not be necessitated. Free action requires indeterminism at the agential level—the kind of indeterminism that is compatible with physical determinism. I still think t

Purpose of review Breathlessness is a common, distressing and limiting symptom in people with advanced disease, but is challenging to assess as the symptom intensity depends on the level of exertion (symptom stimulus) during the assessment. This review outlines how to use recently developed normative reference equations to evaluate breathlessness responses, accounting for level of exertion, for va