When technology meets cell biology Lysosomes are small bags present in our cells that are filled with destructive molecules, normally needed for removing cell garbage. In some cases, these bags rupture and their contents leak into the interior of the cell leading to cell death. This can contribute to many diseases, such as Alzheimer’s disease. However, rupturing lysosomes intentionally, can also

The immune system is the main defense barrier against infections but exerts selection pressures on other life history traits. Recent studies have given importance to understanding the role of the immune system in birds, and it has been hypothesized that during migration, birds either increase their immune function, as they might encounter novel pathogens, or decrease it to account for the cost of

Analysis of priming and licensing signals detected by pattern recognition receptors in murine macrophages Vårt immunsystem är uppdelat i två delar, det medfödda och det adaptiva. Det medfödda immunsystemet består av fysiska (hud och slem) och kemiska barriärer (lågt pH i magen och amylaser i saliv), samt cellulära komponenter. I den cellulära komponenten av det medfödda immunsystemet finns en väl

This thesis explores the ways in which ‘‘Ides of March, 2020’’ (2020) by Didi Jackson, ‘‘Sing a Darkness’’ (2020) by Carl Phillips, and ‘‘Desert Lily’’ (2020) by Rigoberto González engage with concepts of nature and trauma. All three poems reveal poignant elaborations on human position and relationship to nature, and how nature might help the speakers dealing with the traumatic present of the pand

The thesis discusses the issue of shared responsibility in international law. In particular, how States may be held accountable for the commission of torture in the context of armed conflicts. Part I discusses the definition of torture under IHRL and IHL, the obligations of States deriving from international treaties. Part II discusses the question of shared responsibility and loopholes in the cu

Open source software is becoming more common in software development today and constitutes an increasing share in modern web applications. Open source has many benefits; it is cost-effective and increases development speed, quality, and security. With the advent of open source, companies and organizations have taken many different initiatives to minimize the risks of open source, disseminate knowl

Mitt examensarbete är en undersökning på hur ett nutida generationsboende kan utformas samt vilka sociala utbyten det kan bidra till. Syftet är att gestalta ett fritidshus i form av ett generationsboende ur ett socialt och hållbart perspektiv. Huset är beläget på en befintlig gård ute på Värmlandsnäs och ska ge utrymme för fyra familjer. För att skapa en större förståelse kring generationsboende

Ett skräddarsytt immunförsvar Våra kroppar är ständigt utsatta för patogena mikrober och virus men våra immunceller håller oss allt som oftast friska. Några av immunförsvarets viktigaste celltyper är de så kallade specifika immuncellerna: ”T” och ”B” celler. I detta mastersarbete har jag studerat hur antikroppssvaret som B celler producerar förändras över tid och i samspel med de follikulära T hjHigh affinity antibodies of appropriate isotype are crucial for protection against pathogens and are generated within secondary lymphoid organs in structures called germinal centers (GC). Apart from affinity maturation, germinal centers also give rise to memory B cells and plasma cells, but how these fate decisions are regulated and what signals may be delivered by TFH cells is still unclear. Usin

The UK has recently increased its 80% GHG emissions reduction target to net-zero by 2050 compared to 1990 levels. To achieve this goal, the UK emphasizes deploying the technology Bioenergy Carbon Capture and Storage (BECCS). However, despite multiple challenges, BECCS is still prevalent in the UK. This paper aims to identify why this is so by investigating how BECCS is communicated, by whom, and t

Syftet med studien är att undersöka musiklärarnas sätt att beskriva och arbeta med inkludering i kombination med att möta enskilda elevers förutsättningar och samtidigt hålla ihop gruppen. Vidare ämnar studien undersöka vilka inkluderande arbetssätt musiklärarna använder och hur dessa arbetssätt påverkar undervisningens utformning och innehåll samt musiksalens fysiska miljö. Studiens datainsamlingThe purpose of this study is to examine the music teachers’ definitions of inclusive education. A further aim is to examine how these teachers are working to create an inclusive environment for their students and meeting their individual needs while simultaneously holding together the group. Furthermore, this study intends to examine which inclusive teaching methods the music teachers use and how

The goal of this project was to find a way to handle fear and stress through design, mainly aviophobia which is fear of flying. Research was focused on the psycology and physiology of our body when we experience stress as well as how vestibular stimulation could have a calming effect on a person exposed to it. In the design process the hypothesis that movement calms was confirmed by different studie

The COVID-19 crisis has forced many teams to work from home unprepared. This sudden shift proposes various adverse effects on employees' health since stress levels seem to increase in work and private settings. Previous research has identified healthy leadership as a valuable resource for improving the health of employees. This study examined how leaders promote health virtually in their team

In this thesis, we examine the Arnoldi iteration - an iterative algorithm used for finding a Hessenberg form of a matrix as well as approximating its eigenvalues by forming an orthonormal basis of a Krylov subspace. We explore the mechanism behind the work of the algorithm and how the values it finds approximate the eigenvalues. In the process of answering these questions we consider the concepts

The World Health Organization classified Covid-19 as a pandemic in March 2020 which led many countries to recommend social distancing, restrict the freedom of movement and to close everything except necessary services. Covid-19 related research focuses primarily on closures and interruption of cultural services and/or their digitalization. Sweden’s Covid-19 strategy has been different from other c

En metod för att studera cellers vandringsbeteenden genom automatiserad mikroskopi Vår kropp byggs upp av flera olika celler som fyller specifika funktioner. Många celler måste kunna förflytta sig för att utföra sina funktioner. Våra organ formas under fostrets utveckling genom att celler förflyttar sig och immunförsvarets celler vandrar genom kroppen för att jaga och bekämpa smittämnen. Cellers Automated fluorescence microscopy is an emerging technique that enables researchers to generate large amounts of data which in turn allows for large scale quantitative studies. In previous small scale quantitative studies, migration modes found by qualitatively observing migrating lung cancer cells have been described. Since such a method starts from qualitative observations it might not generaliz

Digital tools and support are used today to facilitate and streamline operations in healthcare. In this thesis a qualitative study is conducted which addresses regional digitalization managers attitudes towards digital dictation and speech recognition in healthcare. The study aims to explore attitudes that affect implementation of digital dictation and speech recognition in healthcare. The empiric

Anthropogenic pressure on coastal areas continues to increase, thus intensifying coastal erosion. Coastal monitoring programs are therefore essential to prevent severe ecosystem and economic consequences. Successful coastal monitoring schemes require highly accurate analysis-ready Digital surface models (DSMs) derived using the same workflow. Using a Unmanned Aerial Vehicle – Structure from motion

En av konsekvenserna av klimatförändringen är en ökning av extrema regn. Kraftigt regn har blivit vanligare de senaste åren, troligen kommer nederbörden fortsätta att öka under kommande åren, säger forskarna. Den 10 augusti 2020, föll ett kraftigt regn i Ljungby stad som orsakade många översvämningar i privata och publika områden. Huvudsyftet med denna avhandling är att stötta de som jobbar med koOne of the realized consequences of climate change is a shift in precipitation patterns and an increase in extreme rainfall events. In addition, the growing urbanization trend associated with population and wealth growth has led to an increase in impervious surfaces while reducing groundwater recharge. In Sweden, it is expected that by the end of this century, annual precipitation will continue to

Akustisk blodplasmaseparation med peristaltiska pumpar I Sverige föds varje år cirka 350 extremt prematura barn, vilket innebär att de är födda före 28 graviditetsveckor. För sjukvården så utgör dessa barn en mycket känslig patientgrupp som ofta kräver flera veckors intensivvård på en specialiserad neonatalavdelning. En stor del av barnen drabbas av svåra sjukdomar som påverkar deras utveckling oEarly erythrocyte transfusion is common in infants born extremely premature. Research has shown that these children are at greater risk of morbidity later in life, and that iatrogenic blood loss from blood sample analysis is one of the contributing factors to the need for transfusions. Acoustophoresis-based plasmapheresis could potentially be used to reduce the loss of endogenous blood components

Digital tools in (zoo)archaeology have great potential for education, mediation, and research. Microphotogrammetric 3D-modeling offers new non-intrusive analytical approaches to old problems and questions. This thesis aimed to perform morphological differentiation between cut marks made from lithic and metal tool using qualitative and statistical quantitative approaches (Principal Component Analys