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A common variant of HMGA2 is associated with adult and childhood height in the general population

Human height is a classic, highly heritable quantitative trait. To begin to identify genetic variants influencing height, we examined genome-wide association data from 4,921 individuals. Common variants in the HMGA2 oncogene, exemplified by rs1042725, were associated with height (P= 4x10(-8)). HMGA2 is also a strong biological candidate for height, as rare, severe mutations in this gene alter body

Multiparticle-hole States of High Spin in N

High-spin states of the neutron deficient nucleus Nb-88 have been studied following the reaction Fe-56 (Cl-35, 2pn) Nb-88 at 120 and 123 MeV bombarding energy. Neutron gated and pure gamma gamma-coincidences were measured with a neutron-gamma gamma-coincidence setup; in addition gamma gamma-coincidences were detected with the OSIRIS-cube at the Cologne tandem accelerator. Via the analysis of gamma

Hepatitis E virus infections in patients with acute hepatitis non-A-D in Sweden

A total of 12 patients previously treated for acute hepatitis of unknown aetiology were retrospectively found to be anti-hepatitis E virus (HEV) IgG-positive. Four patients were anti-HEV IgM- and IgG-positive consistent with an acute HEV infection. All 4 had travelled to or were immigrants from HEV-endemic countries. One anti-HEV IgM-negative patient seroconverted from anti-HEV IgG-negative to pos

The upper limit of flammability of hydrogen in air, oxygen, and oxygen-inert mixtures at elevated pressures

The upper limit of flammability of hydrogen in air, oxygen, oxygen-helium, oxygen-neon, oxygen-argon and oxygen-carbon dioxide mixtures was measured at room temperature and pressures between 0.97 and 29 atm in two cylindrical bombs with volumes of 1.5 and 5.2 liters. The limit in ternary mixtures was determined in 20%, 40%, 60% and 80% helium, 20% neon and argon and 10% carbon dioxide concentratio

Test-retest reliability of knee kinesthesia in healthy adults

Background Sensory information from mechanoreceptors in the skin, muscles, tendons, and joint structures plays an important role in joint stability. A joint injury can lead to disruption of the sensory system, which can be measured by proprioceptive acuity. When evaluating proprioception, assessment tools need to be reliable. The aim of this study was to assess the test-retest reliability of a de

Prevalence and clinical correlations of antibodies against six beta 2-glycoprotein-I-related peptides in the antiphospholipid syndrome

Two-hundred ninety five patients with the antiphospholipid syndrome (APS) were studied for the presence of antibodies against six anti-beta2GPI-related peptides Abs. The prevalence of a wide spectrum of clinical and laboratory parameters of APS was evaluated in all patients, and correlated with the presence of each anti-beta2GPI peptide antibody. The rates of the various antipeptides Abs ranged fr

Stochastic asymmetry properties of 3D Gauss-Lagrange ocean waves with directional spreading

In the stochastic Lagrange model for ocean waves the vertical and horizontal location of surface water particles are modeled as correlated Gaussian processes. In this article we investigate the statistical properties of wave characteristics related to wave asymmetry in the 3D Lagrange model. We present a modification of the original Lagrange model that can produce front-back asymmetry both of the

The use of ICF in the neurorehabilitation process.

Rehabilitation is often described as a process that starts when the diagnosis is made and continues as long as the person needs interventions. This process comprises four steps: assessment, goal setting, interventions and outcome measurement. In each step, the WHO International Classification of Functioning, Disability and Health (ICF) can be used and the results can be summarized in a rehabilitat

Dual adaptive extremum control of Hammerstein models

A novel dual adaptive controller for extremum control of stochastic and uncertain nonlinear Hammerstein systems is proposed. The design is based on the innovations dual control cost function originally developed for conventional adaptive control of linear systems. However, the design process is extensively modified and developed so as to cater for the extremum control scenario. This is a more chal

Fruit and vegetable intake and the risk of gastric adenocarcinoma: A reanalysis of the european prospective investigation into cancer and nutrition (EPIC-EURGAST) study after a longer follow-up

In a previous European prospective investigation into cancer and nutrition (EPIC) analysis, we found an inverse association between total intake of vegetables, onion and garlic, and risk of intestinal gastric cancer (GC) and between citrus fruit and risk of cardia GC. The aim of this study is to reanalyze the effect of fruit and vegetables (F&V), based on a longer follow-up and twice the numbe

Self-Assembly and Formation of Chromonic Liquid Crystals from the Dyes Quinaldine Red Acetate and Pyronin Y

The aqueous self-assembly behavior of the dyes Quinaldine red acetate and Pyronin Y in a wide range of concentrations is reported here for the first time. 1H NMR spectroscopy, polarized-light optical microscopy, and small and wide X-ray scattering were used to get insight into molecular interactions, phase boundaries and aggregate structure. Quinaldine red acetate and Pyronin Y self-organize into

Determination of HER2 amplification in primary breast cancer using dual-colour chromogenic in situ hybridization is comparable to fluorescence in situ hybridization: a European multicentre study involving 168 specimens

Aims: Fluorescence in situ hybridization (FISH) can be used to reveal several genomic imbalances relevant to proper cancer diagnosis and to the correct treatment regime. However, FISH requires expensive and advanced fluorescence microscopes in addition to expertise in fluorescence microscopy. To determine whether a newly developed dual-colour chromogenic in situ hybridization (CISH) method is a su