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BACKGROUND: Cancer of unknown primary (CUP) is a fatal cancer for which incidence trends have changed but detailed survival trends remain unexplored. These could point out successful diagnostic and therapeutic approaches. We investigate survival trends in CUP according to histology, locations of metastases and site-specific causes of death. PATIENTS AND METHODS: A total of 20,523 CUP patients with
III-V MOSFETs are currently being considered for digital applications, whereas the option to develop the technology for RF-applications is less often discussed. The quality of the semiconductor/high-k interface and the presence of border traps within the high-k film plays an important role in both types of transistors, but given the different sets of transistor metrics, their influence is differen
In this second article in a series based on various analyses of data from the survey of the vascular flora of the province of Skåne, southern-most Sweden, completed 1987–2007, the geographic distribution of mean indicator values are mapped and discussed. The Ellenberg indicator values are applied and found to correlate well with actual conditions as far as light, temperature and soil reaction (pH)
This study analyzed the relationship between each of five decision-making styles, including Rational, Intuitive, Dependent, Avoidant, and Spontaneous (Scott & Bruce, 1995) and two indicators of stress, Perceived stress and Sleep quality, among administrative officers and investigators at three Swedish public authorities: The National Tax board, the Social Insurance agency, and the Police autho
Background: The palliative care approach was originally developed for hospice care and for persons with cancer diseases, but has gradually expanded to embrace other contexts and people of all ages, with various life-threatening diseases. The palliative care concept thus also applies to older people and the context of municipal care, where Registered Nurses (RNs) hold key care provision positions.
A search for the Standard Model Higgs boson decaying into a pair of tau leptons is reported. The analysis is based on a data sample of proton-proton collisions collected by the ATLAS experiment at the LHC and corresponding to an integrated luminosity of 4.7 fb(-1). No significant excess over the expected background is observed in the Higgs boson mass range of 100-150GeV. The observed (expected) up
A robust and stable film comprising n-octylpyridinum hexafluorophosphate ([C8Py][PF6]) and 1:12 phosphomolybdic acid (PMo12) was prepared on glassy carbon electrodes modified with multiwall carbon nanotubes (GCE/MWCNTs) by dip-coating. The cyclic voltammograms of the GCE/MWCNTs/[C8Py][PF6]-PMo12 showed three well-defined pairs of redox peaks due to the PMo12 system. The surface coverage for the im
Background: The effects on left and right ventricular (LV, RV) volumes during physical exercise remains controversial. Furthermore, no previous study has investigated the effects of exercise on longitudinal contribution to stroke volume (SV) and the outer volume variation of the heart. The aim of this study was to determine if LV, RV and total heart volumes (THV) as well as cardiac pumping mechani
Glucagon-like peptide-1 (GLP-1)-based therapy of type 2 diabetes is executed either by GLP-1 receptor agonists, which stimulate the GLP-1 receptors, or by dipeptidyl peptidase-4 (DPP-4) inhibitors, which prevent the inactivation of endogenous GLP-1 thereby increasing the concentration of endogenous active GLP-1. GLP-1 activates pancreatic receptors resulting in improved glycemia through glucose-de
Background:Membranous expression of the anti-adhesive glycoprotein podocalyxin-like (PODXL) has previously been found to correlate with poor prognosis in several major cancer forms. Here we examined the prognostic impact of PODXL expression in urothelial bladder cancer.Methods:Immunohistochemical PODXL expression was examined in tissue microarrays with tumours from two independent cohorts of patie
PDE3 regulates cAMP-mediated signaling in the heart, and PDE3 inhibitors augment contractility in patients with heart failure. Studies in mice showed that PDE3A, not PDE3B, is the subfamily responsible for these inotropic effects, and that murine PDE3A1 associates with SERCA2, PLB and AKAP18 in a multi-protein signalosome in human SR. Immunohistochemical staining demonstrated that PDE3A co-localiz
In the mid-1970s it was discovered that some man-made products destroy ozone molecules in the stratosphere. This destruction leads to higher ultraviolet (UV) radiation levels at the surface of the Earth and can cause damage to ecosystems and to materials such as plastics. Itmay cause an increase in human diseases such as skin cancers and cataracts. The discovery of the role of the synthetic ozone-
Precision agriculture requires detailed crop status information at high spatial and temporal resolutions. Remote sensing can provide such information, but single sensor observations are often incapable of meeting all data requirements. Spectral-temporal response surfaces (STRSs) provide continuous reflectance spectra at high temporal intervals. This is the first study to combine multispectral sate
In hybrid zones populations that are otherwise allopatric meet and produce hybrids. One of the most well-known hybrid zones occurs throughout much of Europe between the hooded and carrion crows. Even though these species (or subspecies) of crows look very different, genetic differentiation is weak, and introgression seems to be common. In a spatial simulation that was based on empirically estimate
One group of commonly found parasites in birds, for which fitness consequences and effects on life history traits have been much debated are Haemosporidian blood parasites. In a long term study population of great reed warblers Acrocephalus arundinaceus in Sweden, previous studies have shown that the Haemosporidian blood parasites are in their chronic phase during the breeding season and that the
Objective: To analyse discrepant breast cancer detection in digital breast tomosynthesis (DBT) and digital mammography (DM). Methods: From a previous detection study comparing DBT and DM, 26 discrepant cases were extracted, 19 detected by DBT only and 7 by DM only. An expert panel of 3 radiologists reviewed these cases and documented level of discrepancy, lesion visibility, radiographic pattern, l
The rate of constitutive isoprenoid emissions from plants is driven by plant emission capacity under specified environmental conditions (E-S, the emission factor) and by responsiveness of the emissions to instantaneous variations in environment. In models of isoprenoid emission, E-S has been often considered as intrinsic species-specific constant invariable in time and space. Here we analyze the v
