We have determined the structure of the homotrimeric dUTPase from Escherichia coli, complexed with an inhibitor and substrate analogue, dUDP. Three molecules of dUDP are found symmetrically bound per trimer, each in a shallow cleft between adjacent subunits, interacting with evolutionary conserved residues. The interactions of the uracil ring and the deoxypentose with the protein are consistent wi

Popular Abstract in Swedish Avhandlingen ”Tingens och tankarnas landskap” söker arkeologiska metoder och teorier för ett humanistiskt närmande av människans tidiga naturumgänge. Med arkeologiskt menas här fokuseringen på de materiella spåren i landskapet, stora som små, naturdanade som människotillverkade. Tidsperspektivet är i huvudsak långtida. I avhandlingen har jag valt ett ekologiskt perspektThe thesis "Tingens och tankarnas landskap" is about the material traces of man and his activities in the past. The study investigates the possibility and methods of describing man’s interaction with nature. Man’s relationship to the physical surroundings is viewed from cultural and social perspectives, using the materials of long-term archaeology. The study also includes a contemporary dimension.

Using LEED and angle resolved photoemission for characterisation we have prepared graphite overlayers with down to monolayer thickness by heating SiC crystals and monitored alkali metal intercalation for the multilayer films. The valence band structure of the monolayer is similar to that calculated for graphene though downshifted by around 0.8 eV and with a small gap at the zone corner. The shift

Abstract is not available. This is the final accepted and revised manuscript of the article.

Objectives: To compare the oldest old (85 years and above) in pain with those with no pain across gender, regarding demographic data, living conditions, social network/support, walking/mobility problems, fatigue, sleeping problems, depressed mood and quality of life (QoL). The aim was also to test how these variables were related to QoL among the oldest old in pain. Methods: The study comprised 16

Urokinase, a serine protease, catalyzes the conversion of plasminogen to plasmin, which is responsible for dissolution of clots in blood vessels. It is an important drug for treatment of thromboembolic disease. Production of urokinase by mammalian cell culture has the following important steps: synthesis, regulation and secretion. Production and accumulation of this product in a bioreactor is a re

Rapporten behandlar utformning av anslutningen mellan yttervägg och platta på mark samt dess inverkan på fukttillståndet i syllar av främst trämaterial. Undersökningen omfattade dels fältmätningar och dels koretiska beräkningar, dessutom gjordes en del laboratorieförsök. Rekommendationer för utformning.

The ovaries of 377 women between the age of 40 and 70 years were measured by ultrasound. About one third of the patients were postmenopausal. Mean value, standard deviation and S.E.M. of the ovarian volume were calculated and related to age, parity and menstrual cycle. Ovarian size decreased with age in all women but bore no relation to parity and day of menstrual cycle in the menstruating group o

We evaluated the incidence and clinical significance of postfracture shortening of the clavicle in 85 patients. There were 71 mid-clavicular fractures and 14 of the lateral end of the clavicle. 46 fractures were primarily undisplaced and 39 displaced. All fractures were nonoperatively treated with sling immobilization. All patients were reexamined 5 years after the fracture. 35 clavicles had heale

Taxa within the Dactylorhiza incarnata/maculata species complex form a diploid and tetraploid complex. The genetic variation revealed by molecular markers indicate that this is a young complex and that polyploidization may be an ongoing process; most, if not all, of the polyploid taxa may have evolved after the last ice age. This conclusion is supported by 1) a close correspondence in general dist

Responses to isotonic quick release of AC-stimulated smooth muscle strips from rabbit urinary bladder were analysed. Releases were performed at the peak of contraction and at a preset tension level in the contraction and relaxation phase. In other expts. responses at 37 degrees C and 27 degrees C were compared. The length response always consisted of 3 parts: (1) elastic recoil, (2) rapid length c

We calculate the cross section for c(c) over bar g -production in diffractive DIS with finite quark masses at zero momentum transfer t. The calculation is done in the leading log(1/x(P)) approximation and is valid in the region of high diffractive masses M (small 3). We apply our cross section formula including both c (c) over bar- and c(c) over bar g in a Monte Carlo simulation to diffractive D*(