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PURPOSE: To determine the impact of the implementation of novel systemic regimens and locoregional treatment modalities on survival at population level in colorectal cancer (CRC) patients presenting with peritoneal metastases (PMs).METHODS: All consecutive CRC patients with synchronous PM (<3 months) between 1995 and 2014 were extracted from the Eindhoven area of the Netherlands Cancer Registry. T

PURPOSE In the randomized open-label phase III OVHIPEC trial, the addition of hyperthermic intraperitoneal chemotherapy (HIPEC) to interval cytoreductive surgery (CRS) improved recurrence-free and overall survival in patients with stage III ovarian cancer. We studied the cost effectiveness of the addition of HIPEC to interval CRS in patients with ovarian cancer. PATIENTS AND METHODS We constructed

Hybridization allows adaptations to be shared among lineages and may trigger the evolution of new species1,2. However, convincing examples of homoploid hybrid speciation remain rare because it is challenging to demonstrate that hybridization was crucial in generating reproductive isolation3. Here we combine population genomic analysis with quantitative trait locus mapping of species-specific trait

Background: The 2017 Alzheimer’s disease (AD) Strategic Biomarker Roadmap (SBR) structured the validation of AD diagnostic biomarkers into 5 phases, systematically assessing analytical validity (Phases 1–2), clinical validity (Phases 3–4), and clinical utility (Phase 5) through primary and secondary Aims. This framework allows to map knowledge gaps and research priorities, accelerating the route t

BACKGROUND: The OVHIPEC-1 trial previously showed that the addition of hyperthermic intraperitoneal chemotherapy (HIPEC) to interval cytoreductive surgery resulted in improved progression-free and overall survival compared with cytoreductive surgery alone at 4·7 years of follow-up in patients with stage III epithelial ovarian cancer who were ineligible for primary cytoreduction. We report the fina

Persons with type 2 diabetes born in the regions of famine exposures have disproportionally elevated risk of vision-threatening proliferative diabetic retinopathy (PDR) in adulthood. However, the underlying mechanisms are not known. In the present study, we aimed to investigate the plausible molecular factors underlying progression to PDR. To study the association of genetic variants with PDR unde

Background and Clonal haematopoiesis of indeterminate potential (CHIP), the age-related expansion of blood cells with preleukemic mutaAims tions, is associated with atherosclerotic cardiovascular disease and heart failure. This study aimed to test the association of CHIP with new-onset arrhythmias.Methods UK Biobank participants without prevalent arrhythmias were included. Co-primary study outcome

Circulating cell-free mitochondrial DNA (ccf-mtDNA) is a biomarker of cellular injury or cellular stress and is a potential novel biomarker of psychological stress and of various brain, somatic, and psychiatric disorders. No studies have yet analyzed ccf-mtDNA levels in post-traumatic stress disorder (PTSD), despite evidence of mitochondrial dysfunction in this condition. In the current study, we

We evaluated the predictive value of interim positon emission tomography (I-PET) after one course of chemoimmunotherapy in patients with newly diagnosed diffuse large B-cell lymphoma (DLBCL). One hundred and twelve patients with DLBCL were enrolled. All patients had PET/computed tomography (CT) scans performed after one course of chemotherapy (PET-1). I-PET scans were categorized according to Inte

Aims Delcasertib is a selective inhibitor of delta-protein kinase C (delta-PKC), which reduced infarct size during ischaemia/reperfusion in animal models and diminished myocardial necrosis and improved reperfusion in a pilot study during primary percutaneous coronary intervention (PCI) for ST elevation myocardial infarction (STEMI). Methods and results A multicentre, double-blind trial was perform

Kursen Arbetsorganisation och ledarskap avslutades med en konferens där studenterna presenterade sina projektarbeten. Dessa arbeten är sammanställda i artiklar med olika teman kopplat till dagens arbetsliv. Årets konferens speglar aktuella frågor och utmaningar i näringslivet såsom ökad automation, företags sociala ansvar (CSR), konflikthantering, framgångsfaktorer för nya projektledare, modernt l

Direct lineage reprogramming of glial cells to induced neurons has the potential for restoring brain circuits and function in neuronal disorders and states. We introduce three-dimensional (3D) human glia reprogramming into neurons with a GABAergic interneuron phenotype using stem cell-derived human glia. Single-nucleus RNA sequencing of the converted cells demonstrates distinct neuronal clusters w

Aqueous solutions are crucial in chemistry, biology, environmental science, and technology. The chemistry of solutes is influenced by the surrounding solvation shell of water molecules, which have different chemical properties than bulk water due to their different electronic and geometric structure. It is experimentally challenging to selectively investigate this property-determining electronic a

Professor Kontaktinformation E-post: ulf [dot] soderlund [at] mgeo [dot] lu [dot] seOrganisation Miljö- och geovetenskapliga institutionen (MGeo) Hämtställe: 16 WebbplatsUlf Söderlunds profil i Lunds universitets forskningsportalAndra roller Professor Geologiska institutionenTillsammans med forskare i Kanada koordinerar jag ett internationellt project: Reconstruction of Supercontinents Back To 2.7

https://www.geologi.lu.se/ulf-soderlund - 2026-05-07

Negotiating the Climate Regime: The Process and Its Dynamics lukas LUMES Master’s Thesis 2004 Institutional Bargaining for the Climate Regime The Process and Its Dynamics Lukas Hsin-Chiang Hsu Graduate Institute of Diplomacy National Cheng-Chi University 116 Taipei, Taiwan E-mail:lukas866@hotmail.com Supervisor Karin Bäckstrand, PhD, Wallenberg Research Fellow Department of Political Science Lund

https://www.lumes.lu.se/sites/lumes.lu.se/files/hsu_hsin-chiang_lukas.pdf - 2026-05-07

4th September 2013, Wednesday 17th QMOD-ICQSS Conference 3rd-5th September, 2014 Prague, Czech Republic Program Jointly organized by: Lund University, Linköping University & University of Economics, VŠE, Prague Welcome Address from the Founders of QMOD-ICQSS It is our great pleasure to welcome you to the 17th QMOD-ICQSS conference, the conference which has become one of the largest scientific conf

https://www.ses.lu.se/en/sites/ses.lu.se.en/files/qmod_2014_final_program_with_welcome_20140819_1.pdf - 2026-05-07

Research Article Directly Converted Human Fibroblasts Mature to Neurons and Show Long-Term Survival in Adult Rodent Hippocampus Natalia Avaliani,1 Ulrich Pfisterer,2 Andreas Heuer,2,3 Malin Parmar,2 Merab Kokaia,1 and My Andersson1 1Epilepsy Centre, Lund University Hospital, Lund, Sweden 2Developmental Neurobiology, Lund University, Lund, Sweden 3Molecular Neuromodulation, Lund University, Lund, S

https://www.regenerative-neurobiology.lu.se/sites/regenerative-neurobiology.lu.se/files/publication_in_stem_cells_international.pdf - 2026-05-07

Professor i fri konst Kontaktinformation E-post: joachim [dot] koester [at] khm [dot] lu [dot] seOrganisation Konsthögskolan i Malmö WebbplatsJoachim Koesters profil i Lunds universitets forskningsportalJoachim Koester är en dansk konstnär som har sin bas i Köpenhamn. Hans konstverk har visats på documenta X, Kassel; den 2:a Johannesburgbiennalen; Gwangjubiennalen 1995; den 54:e Venedigbiennalen;

https://www.khm.lu.se/joachim-koester - 2026-05-07

Ferroelectricity in Hf0.5Zr0.5O2 (HZO) originates from a polymorphic landscape where the metastable orthorhombic phase competes with monoclinic and tetragonal forms, making functional properties highly sensitive to structural instability. Recent strategies have exploited ionic-vacancy mechanisms, either through redox interactions with the environment or by employing ferroionic heterostructures, to