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Importance: National Institute on Aging-Alzheimer's Association (NIA-AA) workgroups have proposed biological research criteria intended to identify individuals with preclinical Alzheimer disease (AD). Objective: To assess the clinical value of these biological criteria to identify older individuals without cognitive impairment who are at near-term risk of developing symptomatic AD. Design, Setting

Tricuspid regurgitation (TR) is a highly prevalent condition and an independent risk factor for adverse outcomes. Multiple clinical guidelines exist for the diagnosis and management of TR, but the recommendations may sometimes vary. We systematically reviewed high-quality guidelines with a specific focus on areas of agreement, disagreement, and gaps in evidence. We searched MEDLINE and EMBASE (1 J

This paper presents a comparison among eight tools commonly used to evaluate the solar irradiation in urban environments. The focus is on the vertical surfaces (i.e., façades). The analysed tools have a large range of applications, from detailed microclimate studies to large-scale irradiation modelling. The benchmark tests consist of simulations using two conceptual urban designs. Two representati

Följande rapport har gjorts i utbildningssyfte i kursen Brandteknisk Riskvärdering på brandingenjörsprogrammet på Lunds Tekniska högskola. Rapporten är en brandteknisk riskvärdering med personsäkerhet i fokus över objektet Galleria Gränden i Linköping som är en välbesökt galleria i centrala Linköping med upp till tusentals besökare varje dag. Objektet har ett omfattande befintligt brandskydd. I stThe purpose of the report is to evaluate the fire safety design of Galleria Gränden, a mall located in central Linköping. Only the personal safety for the occupants have been taken into consideration. An onsite inspection was conducted to make measurements but also to inspect the fire safety installations to get a general perception of the fire risk in the building. An initial risk analysis was ma

Background: Deep learning (DL)-based organ segmentation is increasingly used in radiotherapy. While methods exist to generate voxel-wise uncertainty maps from DL-based auto-segmentation models, these maps are rarely presented to clinicians. Purpose: This study aimed to evaluate the impact of DL-generated uncertainty maps on experienced radiation oncologists during the manual correction of DL-based

Post-compression of (sub)-picosecond laser pulses down to sub-100 fs durations has become a standard approach for high-peak-power sources at a high average power [1]. Here, we propose a new post-compression geometry suited for extreme temporal compression of energetic narrowband lasers, such as diode or electrically pumped four-level systems which can deliver kW-average powers [2], but typically e

1 Readings Total pages of reading: 1104 Required readings: 904 Student-selected (from literature list): 200 *Alves, Ana Christina, and Lee, Su-Hyun. 2021. “China’s BRI developmental agency in its own words: A content analysis of key policy documents.” World Development https://doi.org/10.1016/j.worlddev.2021.105715 • 13 pages. *Anbumozhi, V. and Yao, X., 2017. Remaking Energy Policies for Global S

https://www.ace.lu.se/sites/ace.lu.se/files/2024-06/COSM34-Literature%20list.pdf - 2026-01-19

Kursbudget Välj kurs VT24 ERROR:#N/A Kursansvarig: Datum: Kursbudget Tilldelning ERROR:#N/A Utgifter Personalkostnader, GU-kont 0 kr Doktorandkostnader 0 kr Personal kostnader, ej GU kont 0 kr Driftskostnader m m 0 kr SUMMA kurskostnader 0 kr RESULTAT ERROR:#N/A Studerandeantal : kostnad/student: ERROR:#DIV/0! Instruktioner: Välj kurs i kurslistan. Då kommer tilldelningen upp. Fyll i datum och nam

https://www.biologyeducation.lu.se/sites/biologyeducation.lu.se/files/2024-04/KursbudgetmallVT24.xlsx - 2026-01-19

Kursbudget Välj kurs HT24 ERROR:#N/A Kursansvarig: Datum: Kursbudget Tilldelning ERROR:#N/A Utgifter Personalkostnader, GU-kont 0 kr Doktorandkostnader 0 kr Personal kostnader, ej GU kont 0 kr Driftskostnader m m 0 kr SUMMA kurskostnader 0 kr RESULTAT ERROR:#N/A Studerandeantal : kostnad/student: ERROR:#DIV/0! Instruktioner: Välj kurs i kurslistan. Då kommer tilldelningen upp. Fyll i datum och nam

https://www.biologyeducation.lu.se/sites/biologyeducation.lu.se/files/2024-08/KursbudgetmallHT24.xlsx - 2026-01-19

Chronic infection perturbs immune homeostasis. While prior studies have reported dysregulation of effector and memory cells, little is known about the effects on naïve T cell populations. We performed a cross-sectional study of chronic hepatitis C (cHCV) patients using tetramer-associated magnetic enrichment to study antigen-specific inexperienced CD8(+) T cells (i.e., tumor or unrelated virus-spe

The approach to the diagnosis of acute pulmonary embolism (PE) is under constant revision with advances in technology, noninvasive approaches, and increasing awareness of the risks of ionizing radiation. Optimal approaches in some categories of patients are controversial. Data are insufficient for evidence-based recommendations. Therefore, this survey of investigators in the field was undertaken.

The scale, rate, and intensity of humans’ environmental impact has engendered broad discussion about how to find plausible pathways of development that hold the most promise for fostering a better future in the Anthropocene. However, the dominance of dystopian visions of irreversible environmental degradation and societal collapse, along with overly optimistic utopias and business-as-usual scenari

Motor complications in Parkinson's disease (PD) are associated with long-term oral levodopa treatment and linked to pulsatile dopaminergic stimulation. l-dopa-carbidopa intestinal gel (LCIG) is delivered continuously by percutaneous endoscopic gastrojejunostomy tube (PEG-J), which reduces l-dopa-plasma-level fluctuations and can translate to reduced motor complications. We present final results of

Trilayer graphene exhibits exceptional electronic properties that are of interest both for fundamental science and for technological applications. The ability to achieve a high on-off current ratio is the central question in this field. Here, we propose a simple method to achieve a current on-off ratio of 10(4) by opening a transport gap in Bernal-stacked trilayer graphene. We synthesized Bernal-s

Type 2 diabetes mellitus (T2DM) is a major disease affecting nearly 280 million people worldwide. Whilst the pathophysiological mechanisms leading to disease are poorly understood, dysfunction of the insulin-producing pancreatic beta-cells is key event for disease development. Monitoring the gene expression profiles of pancreatic beta-cells under several genetic or chemical perturbations has shed

Ovarian cancer patients are typically treated with carboplatin and paclitaxel, but suffer a high rate of relapse with recalcitrant disease. This challenge has fostered the development of novel approaches to treatment, including antagonists of the 'inhibitor of apoptosis proteins' (IAPs), also called SMAC mimetics, as apoptosis-inducing agents whose action is opposed by caspase inhibitors. Surprisi

INTRODUCTION: Post-traumatic stress disorder (PTSD) has been associated with immune disturbances, including a higher incidence of infections and autoimmune diseases as well as a net pro-inflammatory state. Natural killer (NK) cells, a key component of the innate immune system, have been less well-studied in PTSD despite their importance in immunity.METHODS: We studied two independent samples of co