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Objectives To assess the association between neonatal BCG vaccination and mortality between 28 days and 3 years of age among tuberculosis (TB)-exposed and TB-unexposed children. Design Prospective cohort study. Setting Bandim Health Project runs an urban Health and Demographic Surveillance site in Guinea-Bissau with registration of mortality, vaccination status and TB cases. Participants Children
For drug delivery, characterization of liposomes regarding size, particle number concentrations, occurrence of low-sized liposome artefacts and drug encapsulation are of importance to understand their pharmacodynamic properties. In our study, we aimed to demonstrate the applicability of nano Electrospray Gas-Phase Electrophoretic Mobility Molecular Analyser (nES GEMMA) as a suitable technique for
Humoral immunity is important in limiting clinical disease in malaria, yet the longitudinal B cell response to infection remains unclear. We performed a 1-year prospective study in patients treated for acute Plasmodium falciparum malaria for the first time or with previous exposure to the disease. Using an unbiased exploratory approach with mass cytometry, followed by targeted flow cytometry, we f
Hepatocellular carcinoma (HCC) is associated with high mortality and the current therapy for advanced HCC, Sorafenib, offers limited survival benefits. Here we assessed whether combining the TLR3 agonist: lysine-stabilized polyinosinicpolycytidylic- acid (poly-ICLC) with Sorafenib could enhance tumor control in HCC. Combinatorial therapy with poly-ICLC and Sorafenib increased apoptosis and reduced
The causal association of NUDT1 (=MTH1) and OGG1 with hereditary colorectal cancer (CRC) remains unclear. Here, we sought to provide additional evidence for or against the causal contribution of NUDT1 and OGG1 mutations to hereditary CRC and/or polyposis. Mutational screening was performed using pooled DNA amplification and targeted next-generation sequencing in 529 families (441 uncharacterized M
Introduction: Peritoneal metastases (PM) originating from colorectal cancer (CRC) and pseudomyxoma peritonei (PMP) can be treated with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). Certain sites in the peritoneal cavity are prone to contain PM and are, therefore, routinely resected. The aim of this study is to investigate the frequency of disease in CRS specime
Universitetslektor Kontaktinformation E-post: edith [dot] hammer [at] biol [dot] lu [dot] se Telefon: +46 46 222 45 36 Mobil: +46 73 244 19 68Organisation Funktionell ekologi Besöksadress: Kontaktvägen 10, Lund Rumsnummer: A224 Hämtställe: 50 WebbplatsEdith Hammers profil i Lunds universitets forskningsportalAndra roller Forskare Miljö- och geovetenskapliga institutionen (MGeo) Medlem i Strategisk
https://www.cec.lu.se/sv/edith-hammer - 2026-07-16
1 COSB60: Contemporary Korean Society, 7.5 Credits Fall Semester 2024 2024-10-02 – 2024-12-03 Course Director: Youngeun Koo E-mail: youngeun.koo@ace.lu.se Course Outline (as of 20 September 2024; subject to further change) COURSE CONTENT The course provides students with a basic understanding of key issues in contemporary Korean society. It focuses on post-Cold War Korea. The course covers topics
https://www.ace.lu.se/sites/ace.lu.se/files/2024-09/COSB60_Course%20Outline_2024.9.20.pdf - 2026-07-17
1 COSB60: Contemporary Korean Society, 7.5 Credits Fall Semester 2024 2024-10-02 – 2024-12-03 Course Director: Youngeun Koo E-mail: youngeun.koo@ace.lu.se Course Outline (as of 27 August 2024; subject to further change) COURSE CONTENT The course provides students with a basic understanding of key issues in contemporary Korean society. It focuses on post-Cold War Korea. The course covers topics suc
https://www.ace.lu.se/sites/ace.lu.se/files/2024-08/COSB60_Course%20Outline_2024.8.27.pdf - 2026-07-17
The High Throughput Truthing project aims to develop a dataset for validating artificial intelligence and machine learning models (AI/ML) fit for regulatory purposes. The context of this AI/ML validation dataset is the reporting of stromal tumor-infiltrating lymphocytes (sTILs) density evaluations in hematoxylin and eosin-stained invasive breast cancer biopsy specimens. After completing the pilot
We describe an entomological dual-band 808 and 980 nm lidar system which has been implemented in a tropical cloud forest (Ecuador). The system was successfully tested at a sample rate of 5 kHz in a cloud forest during challenging foggy conditions (extinction coefficients up to 20 km–1). At times, the backscattered signal could be retrieved from a distance of 2.929 km. We present insect and bat obs
Aims: The present study aimed at testing the hypothesis that atrial fibrillatory rate (AFR) is predictive of sinus rhythm maintenance after electrical cardioversion. Methods and results: The study comprised 32 patients admitted for cardioversion of atrial fibrillation of short duration (mean duration 3.8 ± 7.7 days). AFR was estimated using frequency power spectrum analysis of QRST-cancelled ECG.
We used the paradigmatic GATA-PU.1 axis to explore, at the systems level, dynamic relationships between transcription factor (TF) binding and global gene expression programs as multipotent cells differentiate. We combined global ChIP-seq of GATA1, GATA2, and PU.1 with expression profiling during differentiation to erythroid and neutrophil lineages. Our analysis reveals (1) differential complexity
Many bacteria have evolved ways to interact with glycosylation functions of the immune system of their hosts. Streptococcus pyogenes [GAS (group A Streptococcus)] secretes the enzyme EndoS that cleaves glycans on human IgG and impairs the effector functions of the antibody. The ndoS gene, encoding EndoS, has, until now, been thought to be conserved throughout the serotypes. However, in the present
The transcription factor STAT3 is constitutively active in several malignancies including castration-resistant prostate cancer and has been identified as a promising therapeutic target. The fungal metabolite galiellalactone, a STAT3 signaling inhibitor, inhibits the growth, both in vitro and in vivo, of prostate cancer cells expressing active STAT3 and induces apoptosis of prostate cancer stem cel
Background: Over the past decade, several PET tracers were developed to visualise and quantify tau pathology in vivo. However, all these tracers have distinct off-target binding, different dynamic ranges and likely different levels of non-specific binding resulting in large variability in semiquantification. We propose to standardise the sampling and the quantification across all available tau tra
The authors compared dietary pattern methods-cluster analysis, factor analysis, and index analysis-with colorectal cancer risk in the National Institutes of Health (NIH)-AARP Diet and Health Study (n = 492,306). Data from a 124-item food frequency questionnaire (1995-1996) were used to identify 4 clusters for men (3 clusters for women), 3 factors, and 4 indexes. Comparisons were made with adjusted
Popular Abstract in Swedish Två mobila system, ett svenskt och ett italienskt, för undersökning av historiska fasader har använts för att undersöka möjligheten till identifiering av olika material, biologisk påväxt och faktorer som i framtiden kan leda till nedbrytning av kulturhistoriskt värdefulla monument. Undersökningarna visade på möjligheter att genomföra analyser av ytor med hjälp av fluoreThe on-site documentation and examination of architectural heritage has presented challenges for traditional analysis methods in the form of, among other things, large complex structures, sites and environmental conditions. In recent years there has been growing interest in assessing progressing deterioration processes and material analysis, with an emphasis on sustainable conservation and mainten
Abstract in Spanish Antecedentes: Las pruebas cutáneas con determinantes mayores y menores de la penicilina se utilizan de forma habitual para el diagnóstico de reacciones de hipersensibilidad inmediata a los antibióticos betalactámicos. Estos extractos diagnósticos han sido recientemente retirados del mercado europeo. Objetivo: Estudio de una nueva marca de determinantes para el diagnóstico de reBACKGROUND: Skin testing with major and minor determinants of benzylpenicillin is recommended standard practice for the evaluation of patients with immediate hypersensitivity reactions to beta-lactams. However, commercial reagents for this purpose were recently dropped from the European market. OBJECTIVE: In the present study, we assessed a new brand of reagents for use in skin testing in patients
Low frequency vibrations in footbridges is a cause of annoyance for pedestrians crossing the bridge. Bagers bro, a footbridge built in Malmö (Sweden) had several constraints in the physical design that caused the first eigenmode of the bridge to be at 1.8Hz which is a severe problem for pedestrians. Therefore the bridge was fitted with tuned mass dampers to mitigate the vibration problem. To evalu
