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Glypicans (GPC1-6) are associated with tumorigenic processes and their involvement in neoplastic behavior has been discussed in different cancer types. Here, a cancer-wide GPC expression study, using clinical cancer patient data in The Cancer Genome Atlas, reveals net upregulation of GPC1 and GPC2 in primary solid tumors, whereas GPC3, GPC5 and GPC6 display lowered expression pattern compared to n
We report pulse energy scaling enabled by the use of Laguerre-Gaussian single-vortex (LG0,l) beams for spectral broadening in a sub-40 cm long Herriott-type bulk multi-pass cell. Beams with orders l=1−3 are generated by a spatial light modulator, which facilitates rapid and precise reconfiguration of the experimental conditions. 180 fs pulses with 610 uJ pulse energy are post-compressed to 44 fs u
Purpose: To examine how intellectual property rights holders and intellectual property rights experts view the phenomenon of characters’ copyright expirations. Research questions: How can intellectual property rights holders cope with the expiration of their characters’ copyright? What are the possible implications of copyright expiration for brands? Methodology: The study utilizes an inductive,
Konceptet personalisering innebär att fokus allt oftare riktas mot individuella politiker och deras personliga egenskaper. Sociala medier, så som Instagram, har gjort konceptet än mer aktuellt då möjligheterna att politiskt kommunicera personligt har ökat genom dessa. Studien ämnade att undersöka om personaliserad kommunikation av framstående svenska politiker på Instagram har ökat under den senasPersonalisation is a concept which is based on the idea that focus is increasingly directed at the individual politician and his or her personal characteristics. Social media, such as Instagram, has revived the concept since the possibilities for personalised political communication have increased. This study aimed to examine if personalised communication among prominent Swedish politicians on Ins
In past years, Sweden has been facing a rapid growth of photovoltaic cells, and the total PV installation capacity increased from 300 kW to 1090 MW (2006–2020). The increased number of PV users was a result of active support from the Swedish government with an aim of achieving multiple sustainable goals regarding renewable energy. This project evaluates the profitability of shared PV systems in co
In order to achieve environmental goals, the impact of the European building stock on the environment needs to be reduced through renovation measures. However, regarding heritage buildings, the choice of measure(s) must simultaneously consider the preservation of cultural and historical values. Besides the impact on such values, energy-efficiency measures can result in increased risks for moisture
2020 Johan Bijnens, Nils Hermansson-Truedsson, Laetitia Laub, Antonio Rodríguez-Sánchez Short-distance HLbL contributions to the muon anomalous magnetic moment beyond perturbation theory LU-TP 20-47, arXiv:2008.13487 [hep-ph] [ abs, pdf ] Alexander Belyaev, Stefan Prestel, Felipe Rojas-Abbate, Jose Zurita Probing Dark Matter with Disappearing Tracks at the LHC LU-TP 20-45, arXiv:2008.08581 [hep-ph
Exacerbation of ST elevation associated with reperfusion has been reported in patients with myocardial infarction. However, the cause of the "reperfusion peak" and relation of its magnitude to the size of myocardial damage has not been explored. The aim of our study was to assess the correlation between the ST-dynamics during reperfusion, the myocardium at risk (MaR), and the infarct size (IS).
The first reported twisted bis-lactam, a racemic Tröger's base (TB) analogue (2), was resolved into its enantiomers on a chiral stationary phase HPLC column. The absolute configuration of (+)-2 was determined to be (R,R)-2 by comparing experimental and calculated vibrational circular dichroism (VCD) and electronic circular dichroism (ECD) spectra. The absolute configuration of (-)-2 was determined
This bachelor’s thesis investigates how medium and large Swedish enterprises perceive data quality during the design and implementation of AI-powered chatbots for internal use. Through five semi-structured interviews with professionals directly involved in the chatbot development, the study explores organisational perspectives on data accuracy, completeness, and reliability, as well as key drivers
When the EU expanded to include ten new countries, the popular opinion was that this would inevitably lead to large increases in trade flows between eastern and western Europe. However, economists have studied the potential for increased trade between the two regions since the fall of the Berlin wall, and much of the evidence indicates that the EU already had a very good bilateral trade relationsh
Consider the communication model (y) over bar = H F (x) over bar + (n) over bar, where H; F are real-valued matrices, (x) over bar is a data vector drawn from some real-valued lattice (e.g. M-PAM), (n) over bar is additive white Gaussian noise and (y) over bar is the received vector. It is assumed that the transmitter and the receiver have perfect knowledge of the channel matrix H (perfect CSI) an
We identify a mutation (D262N) in the erythroid-affiliated transcriptional repressor GFI1B, in an acute myeloid leukemia (AML) patient with antecedent myelodysplastic syndrome (MDS). The GFI1B-D262N mutant functionally antagonizes the transcriptional activity of wild-type GFI1B. GFI1B-D262N promoted myelomonocytic versus erythroid output from primary human hematopoietic precursors and enhanced cel
Popular Abstract in Swedish Avhandlingen analyserar Guatemalas råvaruexport under perioden 1524-1945.In the integrated institutional-staples-‘vent for surplus’ approach, the opening of trade occurs because of initial demand. Once demand is determined, competitiveness is a function of transportation costs, entrepreneurship, capital, land and labour costs, as well as the role played by the State. When all these factors promote competitiveness within an institutional framework that decreased transac
Joint pain is common in haemophilia and may be acute or chronic. Effective pain management in haemophilia is essential to reduce the burden that pain imposes on patients. However, the choice of appropriate pain-relieving measures is challenging, as there is a complex interplay of factors affecting pain perception. This can manifest as differences in patients’ experiences and response to pain, whic
In this paper, a new method for the design of approximately linear phase IIR filters is proposed. This method is based on first designing an asymmetrical FIR filter which is approximately linear phase and then deriving a low order approximately linear phase IIR filter by model reduction techniques.
Biochemical analyses were performed on blood samples obtained from two children (P1, P2) who presented with acute immune thrombocytopenic purpura (ITP) following a recent varicella zoster virus (VZV) infection. Patient sera had antibodies that were reactive with normal blood-group O platelets as measured by flow-cytometric assay. Western blot analysis of electrophoretically separated normal blood-
INTRODUCTION: BAY 81-8973 (Kovaltry®), a recombinant factor VIII (rFVIII) product, was efficacious and well tolerated in paediatric previously treated patients (PTPs) with severe haemophilia A for ≥50 exposure days (EDs) in the LEOPOLD Kids study. Because long-term prophylaxis (≥100 EDs) can provide substantial patient benefits, FVIII products should demonstrate long-term safety and efficacy.AIM:
