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Atomic (1 Å) resolution x-ray structures of horse liver alcohol dehydrogenase in complex with NADH revealed the formation of an adduct in the active site between a metal-bound water and NADH. Furthermore, a pronounced distortion of the pyridine ring of NADH was observed. A series of quantum chemical calculations on the water-nicotinamide adduct showed that the puckering of the pyridine ring in the
BACKGROUND: Several reports have been published on the gender differences associated with allergies in mice. GOAL: In the present study we investigate the influence of gender on allergy response using a strain of mice, B10.RIII, which is commonly used in the collagen-induced arthritis murine model. METHODS: Both male and female B10.RIII young mice were immunized with OVA and challenged four times
The rapid rise of an innovative private manufacturing economy in China challenges standard economic explanations of growth, which typically assume the existence of well-defined formal institutions such as property rights and company laws safeguarding investor and creditor interests. We highlight the social structure of cooperation that enables innovative activity in private manufacturing firms whe
Popular Abstract in Swedish Avhandlingen analyserar Guatemalas råvaruexport under perioden 1524-1945.In the integrated institutional-staples-‘vent for surplus’ approach, the opening of trade occurs because of initial demand. Once demand is determined, competitiveness is a function of transportation costs, entrepreneurship, capital, land and labour costs, as well as the role played by the State. When all these factors promote competitiveness within an institutional framework that decreased transac
Economic institutions enabling trust and cooperation rest on multiplex networks and norms of reciprocity. A key feature of economic institutions is that they facilitate commercial transactions by reducing uncertainty and risk in markets. When trust and trustworthiness stem from confidence in community sanctions of norms, principal and agent relations are enforceable without resorting to legal rule
Many children with adverse reactions to beta-lactams are labelled as allergic without performing an allergy study to confirm it. In this retrospective study of 10 years, we have detected only 3.3% positive cases. Although International Guidelines recommend a second allergy work-up in patients with a negative study, we found from our results a low profitability of retesting.
Risk and return go hand in hand, and one way for a firm to mitigate existing and potential investors' risk in a stock is to employ a financial service; liquidity providing. The value of liquidity provision has become relevant as market uncertainties and shocks in the market create disturbances. In addition, the market environment has changed with regulation and the increase of high-frequency t
Användningen av persondata har blivit ett allt vanligare fenomen och utnyttjandet av data spelar en mer central roll i ekonomin. Data är en värdefull resurs men det har blivit svårare för konsumenter att kontrollera hur data om dem samlas in och delas eller säljs vidare. Många aktörer är ofta involverade i datautvinningsprocessen utan att det framgår vilken roll de spelar och till vilket ändamål d
Att byggsektorn står inför ett rådande klimatnödläge är ett faktum. Idag investeras hundratals miljarder kronor för att i framtiden kunna producera fossilfritt stål; trots det läggs lite fokus på miljöoptimering av konstruktioner. Syftet med arbetet är att utvärdera hur parametrisk design kan användas som verktyg för att miljöoptimera stålstommar i industritrapptorn samt undersöka vilken profiltypThe fact that the construction sector faces a prevailing climate emergency is undeniable. Today, hundreds of billions of kronor are being invested to develop fossil-free steel; yet little focus is placed on environmental optimization of constructions. The purpose of this work is to evaluate how parametric design can be used as a tool for environmental optimization of steel staircase towers, as wel
Denna uppsats undersöker hur Lean Startup-principer kan stödja snabb filtrering och tidig validering av entreprenöriella idéer i osäkra sammanhang. Även om det empiriska fokuset ligger på digital finansiell utbildning för unga yrkesverksamma, är det övergripande målet att bedöma om en strukturerad, hypotesdriven metodik kan främja välinformerat beslutsfattande i de tidiga faserna av affärsutveckliThis thesis explores how Lean Startup principles can support the rapid filtering and early validation of entrepreneurial ideas in uncertain contexts. While the empirical focus is placed on digital financial education for young professionals, the broader objective is to assess whether a structured, hypothesis-driven methodology can support informed decision-making in the early stages of venture des
Adaptive reuse of buildings, repurposing existing structures for new functions, is gaining attention for its potential in sustainable development and optimisation of building materials usage. This practice is particularly relevant in the building sector, where space heating, ventilation, and air conditioning (HVAC) systems represent a significant portion of project costs, embodied energy, greenhou
Two-particle transverse momentum correlation functions are a powerful technique for understanding the dynamics of relativistic heavy-ion collisions. Among these, the transverse momentum correlator G2(Δη, Δφ) is of particular interest for its potential sensitivity to the shear viscosity per unit of entropy density η/ s of the quark-gluon plasma formed in heavy-ion collisions. We use the UrQMD, AMPT
The specific shear viscosity, η/ s, of the quark-gluon plasma formed in ultrarelativistic heavy-ion collisions at RHIC and LHC is estimated based on the progressive longitudinal broadening of transverse momentum two-particle correlators, G2, reported as a function of collision centrality by the STAR and ALICE experiments. Estimates are computed as a function of collision centrality using the Gavin
Neoliberal and conservative actors, financed by the fossil fuel industry, have been identified as crucial parts of a climate change denialist counter movement since at least the 1980s. We claim that this intersection stems from more than just vested interest fuelling advocacy groups. By focusing on the intellectual developments and social networks of core actors in the environmental debate in Swed
Background and objectives For unresectable peritoneal carcinomatosis (PC) median overall survival (OS) is 5-6 months. This article analyzes patients with PC from colorectal cancer (CRC) uneligible for debulking and hyperthermic intra-peritoneal chemotherapy, describing patient-and tumor-related factors possibly affecting survival. Patients and Methods From 2005 to 2009, 43 patients presented with
