Galiellalactone (GL) is a fungal metabolite that presents antitumor activities on prostate cancer in vitro and in vivo. In this study we show that GL induced cell cycle arrest in G2/M phase, caspase-dependent apoptosis and also affected the microtubule organization and migration ability in DU145 cells. GL did not induce double strand DNA break but activated the ATR and ATM-mediated DNA damage resp

This article studies a hitherto unexplored dimension of the Chinese Civil War: the disparity between modern military technology and the conceptual and logistical capacities of the two warring sides. The author argues that the advanced weaponry, received by the Nationalists from their ally, the United States, but often captured on the battlefield by the Chinese Communist Party (CCP) forces, proved

The laccase producing fungus HC1 was isolated from a sample collected in the Bolivian Amazon region. Analysis of 5.8S and 28S rDNA, and internal transcribed spacer 1 and 2 sequences revealed that isolate HC1 belongs to genus Galerina. High production of laccase was achieved in basal salt medium supplemented with 30 g L-1 glucose, 10 g L-1 yeast extract and 0.01 g L-1 copper sulphate. The enzyme pr

One of the most effective methods for obtaining bulk ultrafine-grained materials is severe plastic deformation that is typically done using equal channel angular pressing. In this work we describe and analyze a new method for obtaining severe plastic deformations proposed by the first author. The method is based on direct extrusion and was called "twist extrusion" The main idea of the method is to

Nitrogenase is the only enzyme that can cleave the triple bond in N2, making nitrogen available to organisms. The detailed mechanism of this enzyme is currently not known, and computational studies are complicated by the fact that different density functional theory (DFT) methods give very different energetic results for calculations involving nitrogenase models. Recently, we designed a [Fe(SH)4H]

Background: Microbial production of propionic acid (PA) from renewable resources is limited by the slow growth of the producer bacteria and product-mediated inhibition. The present study evaluates high cell density continuous PA fermentation from glycerol (Gly) using Acidipropionibacterium acidipropionici DSM 4900 in a membrane-based cell recycling system. A ceramic tubular membrane filter of 0.22

Syftet med studien är att undersöka hur revisorer gör sina professionella bedömningar och därigenom skapa en djupare förståelse för varför revisorer tolkar och granskar företags finansiella rapporter på detta sätt. Denna tvärsnittsstudie grundar sig i konstruktivism där materialet samlats in enligt kvalitativ forskningsdesign. Vidare bidrar uppsatsen med ett hermeneutiskt synsätt på revisorns be

Forskningsfrågor: Hur positioneras och marknadsförs vitt snus i Sverige? Vilka budskap sänder vita snusvarumärken i sin reklam och vilka är dessa budskap riktade till? Syfte: Syftet med studien är att beskriva hur det vita snuset är positionerat och marknadsförs på den svenska marknaden för valda fallföretag samt undersöka vilka budskap de sänder, för att bidra till teorin med insikter om positionResearch question: How is white snus positioned and marketed in Sweden? What messages do white snus brands convey in their advertising, and who are these messages targeted towards? Purpose: The aim of the study is to describe how white snus is positioned and marketed in the Swedish market for selected case companies, as well as to examine the messages they convey, in order to contribute to the the

The global business environment has changed rapidly during the past decades; part of that change is the concept of Born Globals. Small and emerging companies are deviating from the traditional globalisation models with incremental steps to internationalisation in favour of turning global from inception. When a Born Global firm acquires Venture Capital, new demands on efficiency and returns are set

För att bygga ett starkt varumärke krävs enhetlighet och starka värden som delas av samtliga medarbetare inom organisationen. Om tolkningsfriheten då blir för stor leder det till att olika värden och känslor kopplas till varumärket. Olika tolkningar kan sätta sig på olika delar av organisationen, vilket i sin tur förmedlas på ett inkonsekvent sätt till kunden.

This thesis experiments with the data structure of a sparse voxel octree (SVO)to see if it may improve the performance of empty space ray marching in volumes. While ray marching is a somewhat new technique it is used more often in traversal of volumes. It can be used for realistic volumetric effects in computer games or it can be used in the medical field when examining and visualizing MRI scans.

Det nya direktivet om offentlig upphandling, Europaparlamentets och rådets direktiv 2014/24/EU, ska implementeras i svensk rätt senast år 2016. Denna uppsats behandlar det nya direktivets betydelse för möjligheterna att ställa krav på sociala hänsyn. Det innefattar även den utveckling som har skett på området sociala hänsyn i övrigt. Direktivet innebär inga större förändringar avseende sociala häThe new directive on public procurement, the European Parliament and Council Directive 2014/24/EU, is to be implemented in Swedish law by the year 2016. This paper discusses the new directive’s significance for opportunities to make demands on social considerations. It also includes the development that has taken place in the area of social considerations in general. The directive involves no maj

This paper takes off in the rapidly growing fields of financial independence and financial literacy. We develop a model focusing on reaching financial independence during retirement and mitigate financial decision making for financially illiterate. The model is based on theoretical research within financial literacy, economic life-cycle and safe withdrawal rates. To ensure qualified monthly saving