Effects of TGFβ on the extra cellular matrix and its architects the fibroblasts Fibroblasts are the main architects of the extra cellular matrix (ECM), the non-cellular structure, surrounding the cells throughout the body. The ECM and fibroblasts are constantly communicating with neighboring cells, and an imbalanced ECM state can have detrimental impacts in the organism. In diseases like cancer,

Kostnads-nyttoanalyser används inom många sektorer av samhället för att utvärdera och jämföra olika investeringars lönsamhet. När kostnads-nyttoanalyser tillämpas på riskreducerande åtgärder innebär det ett avvägande mellan kostnad och säkerhet, vilket medför både praktiska och etiska utmaningar. Planeringen för byggande av nya, och utveckling av befintliga, vägar och järnvägar är omfattande proCost benefit analysis is a valuable tool for making sustainable decisions in many sectors of society. This master thesis examines the application of cost benefit analysis for safety measures in infrastructure planning in Sweden with the aim to identify difficulties and possible improvements. This was accomplished by examining implemented cost benefit analyses and performing qualitative interviews

The construction workflow of in-situ concrete frames in multi-storey residential buildings is highly complex and dynamic. Discrete-event simulation (DES) offers capabilities to model and analyse such complexity. Although DES has successfully been used by researchers in a wide range of construction-related applications there are not many examples demonstrating how different simulation outputs (time

This report presents an integrated simulation-based approach to study the on-site production of concrete frameworks by considering the multiple effects of weather on work task productivity and concrete curing process. The suggested approach enable to systematically study how different weather conditions and the use of climate-improved concrete in combination with different methods to shield concre

Sustainability-driven businesses combine the principles of conventional for-profit companies with a strong commitment to their social and environmental credentials. This structure enables them to address social problems in an economically sustainable manner and to capitalise on consumer demand for responsibly-made products. The growth of sustainability-driven companies is often seen as another suc

Inledning och problembakgrund redogör för hur digitaliseringen förändrar både människor och organisationers praktiker och hur detta på olika vis påverkar handeln. Tidigare forskning på området har antingen fokuserat på servicearbetet eller på konsumenters och organisationers användning av teknologi. Treadgold och Reynolds (2016) tillsammans med Fuentes och Svingstedt (2017) tar upp digitaliseringe

Ultraljud och mikrochip kan hjälpa oss att förstå cancer bättre En tumör och dess omgivning spelar stor roll i hur cancer utvecklas och genom att förstå vilka celler den består av och sortera ut de viktigaste kan man öka kunskapen om hur cancern bäst ska bekämpas. I detta arbete har immunceller från sådan upplöst bröstvävnad sorteras ut med hjälp av ett mikrochip med små kanaler samt en ultraljudThe aim of this thesis was to compare different ways of dissociating tissue - specifically breast cancer tissue - and sorting out tumour cells and immune cells from the dissociated tissue using acoustophoresis in a microfluidic chip. Due to ethical issues with using tumour tissues to work on the methodology of a project, ultimately only healthy breast tissue was used in this work. Two dissociatio

The study investigates the design of kené, a geometrical pattern originated in the culture of Shipibo, in relation to Gilles Deleuze and Félix Guattaris’ philosophical term rhizome. Kené is, besides the nowadays more influential part of the Shipibo material culture of handicraft, historically connected to healing practices which includes the hallucinogenic brew ayahuasca. The thesis is an autoethn

Around 60 million people around the world are struggling with a traumatic brain or spinal cord injury. The swelling of the brain or spinal cord happen when the water content in the CNS increase due, infection, tumor growth or brain edema. AQP4 is a membrane water channel which mediates the water flux across the blood brain barrier (BBB) and blood spinal-cord barrier (BSCB). We believe that protein

This study assessed the work of individuals, organizations and the state in the promotion of women’s right to education after the Taliban regime in Afghanistan. It drew from the theories of feminism and masculinity as well as Feminist Security Studies and gender and development studies. In order to achieve its objective, the study adopted a triangulated research method which involved Discourse Ana

Museums today try to combat the exclusionary ground on which they were founded, with strategies of broader inclusion. In Århus, Denmark the Women’s museums vision is to be a museum for ”all genders”. In this thesis I investigate the approach to gender in the Women’s museum’s exhibition Køn Redelighed (eng. Gender Blender) (2017-2022), through a queer theoretic lense of gender as a hybrid and discu

This master thesis examined the microstructure after heat treatments in stainless steel, two conventional stainless steel (304 and 316) and two novel high temperature stainless steel. These stainless steels are for the use in high temperature heat exchangers for extended temperature range. The positive characteristics in stainless steel are inversely correlated to grain size, characteristics such

Proteiner som känner stress Några arter av bakterier är bland människans värsta fiender. De gör oss, vår boskap och våra växter sjuka, de får mat att förruttna, förorenar vatten, och mycket mer. Så för att begränsa och bekämpa dessa bakterier värmer, saltar och syrar vi vår mat och förvarar den i kyla, vi steriliserar sår och ytor med desinfektionsmedel, och vi behandlar sjukdomar med antibiotika

Utgångspunkten för studien är att undersöka allmänhetens ställningstagande kring förändringar inom barnavården under tidsperioden 1900 till 1950. Under denna tidsperiod skedde en övergång från att barnavården var en privat angelägenhet till att bli statlig. År 1937 beslutade riksdagen om att införa fri spädbarnsvård för hela landet, sedan sekelskiftet år 1900 hade liknande verksamhet bedrivits av

Syfte: Denna studie vill bidra till och fördjupa nuvarande forskning inom konsumentbeteenden. Syftet är att bidra med en aktuell förståelse för val av handelskanal, genom att studera hur yngre kvinnliga konsumenter resonerar i sina val mellan e-handel och fysisk butik. Dessutom vill studien bidra med en förståelse om yngre kvinnliga konsumenters moral för att skapa en förståelse för konsumenternas

GABAergic Neurotrasmission – A “cross-talker” between inflammation and neural plasticity in stroke Stroke is a leading cause of disability and no pharmacological treatment is currently available to promote recovery in suffering patients. A major part of research is focusing on finding new biological targets which can be pharmacologically intervened with, providing favorable results in facilitatin

The aim of this study was to evaluate and describe the landscape development in an area located in the municipality of Upplands-Bro, Sweden. The main hypothesis was that the landscape patterns in the study area have changed, as I expected to discover that the landscape has undergone structural changes, in form of both changed land use and changed landscape patch composition. The hypothesis was bas

Plant-insect interactions play a crucial role in the evolution of the coevolving web of life, shaping local interaction networks and moulding the diversity and the evolutionary history of two of the most diverse groups of organisms on earth. The interaction between Lithophragma bolanderi (Saxifragaceae), which presents a geographic mosaic of ploidy levels, and the pollinating floral parasite Greya

This paper analyses how China’s growing taste for beef due to rising incomes, urbanization and preference for higher quality meat shaping Kazakhstan’s inefficient beef industry, and how Kazakhstan’s government is attempting to make it more efficient. The analysis done through qualitative methods by looking into the data from primary and secondary sources.