Ghrelin and CART. Two new islet peptides. Expression, regulation and function.
Popular Abstract in Swedish Denna avhandling redogör för cellulär lokalisation, reglering och funktion av två nya peptider, ghrelin och CART, i pankreas (bukspottskörteln). Pankreas och de Langerhanska öarna: Pankreas består av en exokrin del, som producerar matspjälkningsenzymer till mag-tarm kanalen, och en endokrin del som producerar hormoner som insöndras i blodomloppet. Endokrina pankreas bUntil recently, the islets of Langerhans were thought to harbour four main cell types characterised with respect to principal hormone product. Here we show that the novel hormone ghrelin is expressed in a fifth islet cell type, the islet ghrelin cell, in humans and rodents. The cells are developmentally regulated in that they are numerous around birth and fewer in the adult. The islet ghrelin cell
