Transgenic Huntington's disease (HD) mice, expressing exon 1 of the HD gene with an expanded CAG repeat, are totally resistant to striatal lesion induced by excessive NMDA receptor activation. We now show that striatal lesions induced by the mitochondrial toxin malonate are reduced by 70-80% in transgenic HD mice compared with wild-type littermate controls. This occurred in 6- and 12-week-old HD m

Synthesis of the antimicrobial protein neutrophil gelatinase-associated lipocalin (NGAL) increases dramatically in bronchial epithelial cells and alveolear type II pneumocytes during lung inflammation. IL-1beta induces a >10-fold up-regulation of NGAL expression in the type II pneumocyte-derived cell line A549 cells, whereas TNF-alpha, IL-6, and LPS had no effect. Similar IL-1beta selectivity was

Popular Abstract in Swedish Många av alla kemiska processer som pågår i våra kroppar utförs av proteiner. När de inte fungerar blir vi sjuka. I vissa fall, till exempel vid Alzheimers sjukdom eller Creutzfeld Jacobs sjukdom, beror det på att ett visst protein har fel form. Att förstå hur proteiner antar sin slutliga form och vad det har för inverkan på proteinets funktion är således viktigt. ÅVery little is known about a considerable part of all proteins and it is time consuming and expensive to study each individual protein to determine its function, structure and cellular role. Proteins retain structural, functional and sequential characteristics from ancestral proteins and hence two proteins that share a common ancestor, i.e. are homologs, will to some extent have similar sequen

Phase separation temperatures and viscosities of dilute and semidilute aqueous mixtures of hydrophobically modified graft and block copolymers have been studied. The graft copolymer was hydrophobically modified ethyl(hydroxyethyl)cellulose (HM-EHEC), and the block copolymers were hydrophobically modified poly(ethylene glycol) (HM-PEG) with diblock (DB) or triblock (TB) structures, i.e., modified a

The report shows a validation of the brush tire-model towards measurement data performed in the RFE-project within the IVSS-framework. The data is recorded by VTI at Volvos test track, Hällered. The winter tire, Continental ContiWinterContact TS810 215/55R16 and the summer tire, Continental ContiSportContact 225/45R17 91W are tested longitudinally and laterally at different conditions. A study of

In two previous studies, optimal conditions were identified for two-step steam pretreatment Of SO2- and H2SO4-impregnated softwood. In the present study the yield of sugar and ethanol was determined in a process development unit where pretreatment was performed in a 10-L reactor and simultaneous sacchatification and fermentation (SSF) or enzymatic hydrolysis (EH) were performed in 30-L reactors. T

The mechanisms behind secondary hyperlipidemia in patients with various chronic inflammatory diseases are not known in detail. We have recently demonstrated that ACTH exerts strong hypolipidemic effects in healthy volunteers. To test the clinical relevance of this finding, we administrated ACTH during three weeks to nine hyperlipidemic steroid-treated patients with kidney disease. Before administr

Growth hormone (GH) has insulin-antagonistic effects, and GH secretion is augmented during fasting and hypoglycemia. In the present study, 10 patients aged 21 to 28 years with childhood-onset GH deficiency (GHD) were studied during a 24-hour fast and a hypoglycemic glucose clamp before and after 9 months of GH replacement. During the 24-hour fast, blood glucose, serum insulin, and serum free fatty

In European governance, elements from different administrative and political cultures coalesce into one more complex framework. To capture some of the complexity, two central dimensions are addressed: territoriality and political time, understood as horizon, resource, and process. When investigating European governance the question of the institutional organization is important, since it relates t

Abstract not available

Background Whether or not ankles can be replaced with reasonable safety has been the subject of debate. We present the results of a nationwide series of total ankle arthroplasties. Patients and methods All Swedish hospitals that implant or have implanted modern three-component ankle prostheses reported demographic data and date of index and revision surgery to a central register. After the data ha

We present the first ultraviolet and optical images of η Car and itscircumstellar Homunculus nebula, obtained with the Advanced Camera forSurveys/High Resolution Camera (ACS/HRC) on board the Hubble SpaceTelescope (HST). Compared to those at visual wavelengths, UV imagesreveal excess emission 0.1"-0.6" from the central source along the minoraxis that may emanate from the outer parts of η Car's non

Chondrules are millimeter sized objects of spherical to irregular shape that constitute the major component of chondritic meteorites that originate in the region between Mars and Jupiter and which fall to Earth. They appear to have solidified rapidly from molten or partially molten drops. The heat source that melted the chondrules remains uncertain. The intense radiation from a gamma-ray burst (GR

As the largest single energy-consuming component in most biological wastewater treatment systems, control of aeration is of great interest seen from an energy savings point of view. This paper suggests a simple way of using on-line ammonium measurements to control aeration in a pre-denitrification plant by controlling the dissolved oxygen setpoint. The controller works primarily by feed-forward ba

Predation on large woody plant seeds; chestnuts, acorns and sloe kernels, was studied in deciduous forests of two size classes: small woodlots (< 1 ha) and large woods (at least 25 ha) in southern Sweden. Seeds used for the study were artificially distributed on the forest ground and seed predation measured as seed removal. Predation rate was similar in both types of woods. However, rodent density

Local signs and symptoms were evaluated in 187 consecutively presenting diabetic patients undergoing amputation for foot ulcers. From admission until final outcome the patients were treated by the same multidisciplinary team both as in- and out-patients. At the time of amputation, the types of lesions were superficial/deep ulcer (n 17), ulcer with deep infection, but without gangrene (n 40), and g