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Mechanisms of Escherichia coli induced transepithelial neutrophil migration

Popular Abstract in Swedish Huden och slemhinnor (mukosa) fungerar som kroppens skyddsbarriärer mot yttre angrepp av mikrober, makromolekyler och toxiner och förhindrar dessa att nå inre organ. Trots ett massivt immunskydd sker de flesta infektioner på slemhinnornas ytor. I blodcirkulationen förekommer fem olika typer av vita blodkroppar, alla med olika roller i immunförsvaret. I varje blod finns Mucosal infections trigger an inflammatory response that includes the secretion of cytokines and the recruitment of neutrophils to the infected site. This thesis describes studies examining the molecular mechanisms of neutrophil migration to sites of mucosal bacterial infection. Escherichia coli (E. coli) infection of epithelial cell layers stimulates chemokine secretion and chemokine receptor ex

No title

The basic hypothesis is that mind is an emergent property of the processes that produce natural language expressions. The shape of the mind of a particular person can be discovered through the mechanisms forming the corresponding language space. Although covered by textual surface properties, this space is approachable with VERTEX, which is a new version of Perspective Text Analysis (PTA). Due to

Can pay-for-performance to primary care providers stimulate appropriate use of antibiotics?

Resistance to antibiotics is a major threat to the effectiveness of modern health care. This study examines if pay-for-performance (P4P) to care providers stimulates the appropriate use of antibiotics; in particular, if P4P can induce a substitution away from broad-spectrum antibiotics, which contribute more to the development of resistance, to less resistance-driving types. In the context of Swed

Familjens kris. Fem decennier av svensk familjepolitik

This article analyses the history of the Swedish welfare state, with a special emphasis on the development of Swedish family policy between 1930 and 1975. It is argued that a coalition between state officials and state-appointed experts was active in the shaping and legitimising of the concept of family as well of family politics. The underlying assumption of the paper is that the concepts of the

Biosynthetic and synthetic studies of the fungal metabolite galiellalactone

Galiellalactone is a fungal metabolite found in the basidiomycetes Galiella rufa and the unidentified strain A111-95. It has been shown to possess promising activities as an inhibitor of the IL-6 mediated STAT3 signaling in HepG2 cells. Targeting this pathway is very important when it comes to understanding intracellular signaling and also for developing drugs for treating diseases associated with

Social stress och sociala risker i två städer – ett analysexempel

Människor som lever under social utsatthet bor ofta i särskilda delar av städer. I grannskap som präglas av strukturella riskfaktorer som arbetslöshet, otrygg boendemiljö, trångboddhet och territoriell marginalisering (utsatta bostadsområden), tenderar också befolkningen att utsättas för social stress, ohälsa, social oro och oönskade sociala händelser i högre utsträckning än andra. Detta tydliggör

The Role of Energy in the Industrial Revolution and Modern Economic Growth

The expansion in the supply of energy services over the last couple of centuries has reduced the apparent importance of energy in economic growth despite energy being an essential production input. We demonstrate this by developing a simple extension of the Solow growth model, which we use to investigate 200 years of Swedish data. We find that the elasticity of substitution between a capital-labor

Places of Dying and Rituals of Mourning

The purpose of this paper is to explore in what way the place becomes important for those who are affected by disasters or sudden death. According to human geography people have affective bonds to the concrete physical places where they are living and moving in their everyday live. Places are also constructed as meeting places where people create social relations. In the discotheque fire in Gothen

Försäkringsfusk. Tillvägagångssätt, straffansvar och försäkringsutredning

This study comprises three parts, each of which illustrates different aspects of insurance fraud. The three parts can be seen as independent presentations with their own research findings; but these parts may also be seen together as a whole, giving further perspectives regarding the subject of the study. Part I presents different procedures regarding insurance fraud. This part includes a survey w