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Autoantibodies in systemic lupus erythematosus: comparison of historical and current assessment of seropositivity

Systemic lupus erythematosus (SLE) is characterized by multiple autoantibodies and complement activation. Recent studies have suggested that anti-nuclear antibody (ANA) positivity may disappear over time in some SLE patients. Anti-double-stranded DNA (dsDNA) antibody titers and complement levels may vary with time and immunosuppressive treatment, while the behavior of anti-extractable nuclear anti

Revealing the ultrafast charge carrier dynamics in organo metal halide perovskite solar cell materials using time resolved THz spectroscopy.

Ultrafast charge carrier dynamics in organo metal halide perovskite has been probed using time resolved terahertz (THz) spectroscopy (TRTS). Current literature on its early time characteristics is unanimous: sub-ps charge carrier generation, highly mobile charges and very slow recombination rationalizing the exceptionally high power conversion efficiency for a solution processed solar cell materia

Effect of additives on the melt rheology and thermal degradation of poly[(R)-3-hydroxybutyric acid]

Thermal degradation of poly[(R)−3-hydroxybutyric acid] (PHB) during melt mixing results in random chain scission that produces shorter polymer chains containing crotonic and carboxyl end groups. One way of preventing this serious reduction of molar mass is to add agents that react with at least two of the newly generated end groups. Different types of commercially available additives known to reac

Blood lipids in 75,048 type 2 diabetic patients: a population-based survey from the Swedish National diabetes register

Background: Type 2 diabetes and diabetic dyslipidemia are high-risk conditions for cardiovascular disease. However, the description of the distribution of blood lipids in diabetic patients has not been based on population-based surveys. The aim of this study was to describe diabetic dyslipidemia in a large unselected sample of patients from the Swedish National Diabetes Register. Methods: Blood li

Competitive low-tech manufacturing and challenges for regional policy in the European context – lessons from the Danish experience.

Today, low-tech firms in high-wage countries are focusing on increasing investments in highly skilled labour and advanced machinery, incremental innovation and high value-added niches. Danish policy, however, gives little attention to the new specificities of low-tech manufacturing, and the understanding of innovation in national and regional strategies is dominated by a science-based perspective.

Desirable Skills? Non-Nordic citizens applying for work permits in Sweden, 1947–1950

Sweden’s rapid economic growth after World War II meant that the native labour supply was incapable of meeting the high demand, especially for industrial labourers. Three agreements on organised collective transfers were signed, but a large majority of the labour migrants came on their own initiative. Not all applicants were equally welcomed. In this article, logistic regressions are used to inves

Cut-Off Value for Self-Reported Abnormal Cold Sensitivity and Predictors for Abnormality and Severity in Hand Injuries

Our aim was to identify a cut-off value for self-reported, abnormal cold sensitivity and to identify cold sensitivity predictors after hand injuries. The Cold Intolerance Symptom Severity (CISS) questionnaire and a VAS question concerning discomfort on exposure to cold were investigated in 94 normal people and 88 patients. A CISS score >450 was defined as abnormal cold sensitivity. Multiple injure

Coreless vortices in rotating two-component quantum droplets

The rotation of a quantum liquid induces vortices to carry angular momentum. When the system is composed of multiple components that are distinguishable from each other, vortex cores in one component may be filled by particles of the other component, and coreless vortices form. Based on evidence from computational methods, here we show that the formation of coreless vortices occurs very similarly

Molecular recognition with colloidosomes enabled by imprinted polymer nanoparticles and fluorogenic boronic acid

Multifunctional colloidosomes are prepared from molecularly imprinted polymer nanoparticles and fluorogenic boronic acid using a Cu(I)-catalyzed click reaction. The molecular selectivity of the colloidosomes was investigated by radioligand binding analysis, which indicated that the inter-particle click reaction did not affect the molecular specificity of the MIP nanoparticles on the colloidosomes

Objectively best or most acceptable? Expert and lay knowledge in Swedish wind power permit processes

This article analyses legal aspects of the Swedish wind power development, theoretically based on how different types of knowledge are represented in legal contexts, mainly in the courts. A sample of appealed wind power permits is analysed, a handful of relevant informants are interviewed – including two judges in the Land and Environment Court and the appeal court – and the legal setting is analy

Large Density-Functional and Basis-Set Effects for the DMSO Reductase Catalyzed Oxo-Transfer Reaction

The oxygen-atom transfer reaction catalyzed by the mononuclear molybdenum enzyme dimethyl sulfoxide reductase (DMSOR) has attracted considerable attention through both experimental and theoretical studies. We show here that this reaction is more sensitive to details of quantum mechanical calculations than what has previously been appreciated Basis sets of at least triple-zeta quality are needed to

Linking phenological shifts to demographic change

Climate-induced phenological shifts may have serious consequences for organisms and populations, but it is challenging to link such shifts to demographic change. Here, we present an overview of current methodological approaches for studying the demographic consequences of phenological shifts, based on a literature survey of 62 studies on diverse taxa. The majority of these studies (66%) were condu

Common Carotid Intima-Media Thickness Relates to Cardiovascular Events in Adults Aged

Although atherosclerosis starts in early life, evidence on risk factors and atherosclerosis in individuals aged <45 years is scarce. Therefore, we studied the relationship between risk factors, common carotid intima-media thickness (CIMT), and first-time cardiovascular events in adults aged <45 years. Our study population consisted of 3067 adults aged <45 years free from symptomatic cardiovascular

Competitive capacitive biosensing technique (CCBT): A novel technique for monitoring low molecular mass analytes using glucose assay as a model study.

A novel technique for monitoring of low molecular mass analytes using a flow-injection capacitive biosensor is presented. The method is based on the ability of a small molecular mass analyte to displace a large analyte-carrier conjugate from the binding sites of an immobilized biorecognition element with weak affinity to both compounds. A model study was performed on glucose as the small molecular

3D numerical investigation of flow and heat transfer characteristics in smooth wavy fin-and-elliptical tube heat exchangers using new type vortex generators

3D computational analysis was performed to investigate heat transfer and pressure drop characteristics of flow in SWFET (Smooth Wavy Fin-and-Elliptical Tube) heat exchanger with four new VGs (vortex generators), RTW (rectangular trapezoidal winglet), ARW (angle rectangular winglet), CARW (curved angle rectangular winglet) and WW (Wheeler wishbone). The numerical model was well validated with the a

Mosaic variation in allozyme and plastid DNA markers in the European ranges of Silene vulgaris and its partially sympatric relative S-uniflora (Caryophyllaceae)

The perennial herbs Silene vulgaris and S. uniflora are closely related, partially sympatric and interfertile, yet morphologically distinct. We used nuclear (allozyme) and plastid (polymerase chain reaction-restriction fragment length polymorphism) DNA markers to investigate whether these species have a shared history of postglacial colonization and hybridization in Europe, as inferred from large-

Genotype–phenotype correlations in THAP1 dystonia: Molecular foundations and description of new cases

An extensive variety of THAP1 sequence variants have been associated with focal, segmental and generalized dystonia with age of onset ranging from 3 to over 60 years. In previous work, we screened 1114 subjects with mainly adult-onset primary dystonia (Neurology 2010; 74:229-238) and identified 6 missense mutations in THAP1. For this report, we screened 750 additional subjects for mutations in cod