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Pseudomonas aeruginosa is an opportunistic pathogen known for its immune evasive abilities amongst others by degradation of a large variety of host proteins. Here we show that digestion of thrombin by P. aeruginosa elastase leads to the release of the C-terminal thrombin-derived peptide FYT21, which inhibits pro-inflammatory responses to several pathogen-associated molecular patterns in vitro and
Background Ischemic injury of an organ causes metabolic change from aerobic to anaerobic metabolism. It has been shown in experimental studies on the heart and liver that such conversion may be detected by conventional microdialysis probes placed intra-parenchymatously, as well as on organ surfaces, by assaying lactate, pyruvate, glucose, and glycerol in dialysate. We developed a microdialysis pro
Background Although associated with severe clinical complications, phosphate remains a neglected ion. Additionally, phosphate balance during continuous renal replacement therapy (CRRT) is complex and multifunctional. The present retrospective study investigated the effects of phosphate-containing CRRT fluid on phosphate homeostasis. Methods We retrospectively analysed 112 patients treated with CRR
Objectives: Individuals with Parkinson's disease (PD) become unavailable in the workforce earlier than comparable members of the general population. This may result in significant social insurance expenses, but as workforce participation can be a source for social interaction and a vital part of the personal identity, there are likely to be personal implications extending far beyond the economic a
This contribution presents complimentary mineralogical and whole-rock chemical data for the Mullnäset rapakivi massif. Three rock types occur: gabbro, syenite with associated granite and “normal” rapakivi granite, here denoted rapakivi-textured granite. In the syenite-associated granite, extremely Mg-poor clinopyroxene and fayalite are the most important mafic minerals, whereas ferrohornblende and
This article is an in-depth comparative case study of six leadingmanufacturing firms in the Great Zurich region of Switzerland and the Sichuanprovince of China. It employs innovation system approach, institutionalthickness framework and social network analysis to investigate the regionalinstitutions of the two regions and their impact on the connectedness of the casefirms’ internal and external in
The pace at which the world's ecosystems and biodiversity of, e.g., pollinators decline is currently at a rate where it is challenging to document. In recent years, our group has made an effort to bridge the disciplines of laser remote sensing and biophotonics, and we have developed lidar methods for inventorying the biosphere. Here, we present an effective method for extracting fauna observations
Aims: To evaluate the impact of β-cell function on the efficacy of lixisenatide, a once-daily prandial glucagon-like peptide-1 receptor agonist, in patients with type 2 diabetes (T2D). Materials and methods: In this post hoc analysis, patients from the Phase 3 GetGoal-M and GetGoal-S clinical trials randomized to lixisenatide 20. μg once daily were stratified into quartiles by baseline β-cell func
A low power CMOS charge pump (CP) is proposed utilizing a new combination of charge transferring switches for a faster start-up, higher efficiency and lower reverse charge sharing. A low cost feedback mechanism observes the output voltage level and automatically switches off the clock after passing a threshold, which reduces energy dissipation by 62%. It is shown that by using one capacitor per st
With the recent advances towards modern Ion Beam Analysis (IBA), going from one- or few-parameter detector systems to multi-parameter systems, it has been necessary to expand and replace the more than twenty years old CAMAC based system. A new VME multi-parameter (presently up to 200 channels) data acquisition and control system has been developed and implemented at the Lund Ion Beam Analysis Faci
The temperature and density profiles of protoplanetary discs depend crucially on the mass fraction of micrometre-sized dust grains and on their chemical composition. A larger abundance of micrometre-sized grains leads to an overall heating of the disc, so that the water ice line moves further away from the star. An increase in the water fraction inside the disc, maintaining a fixed dust abundance,
In the design of vibration-sensitive structures, large three-dimensional numerical models are frequently used, those occasionally being too large to be simulated in a practical manner. More specifically, the analyses of vibrating complex water-pipe systems require efficient model order reduction strategies. In the paper, a numerical procedure for model order reduction of a water-pipe system housed
In this paper, I reconstruct Robert Nozick's experience machine objection to hedonism about well-being. I then explain and briefly discuss the most important recent criticisms that have been made of it. Finally, I question the conventional wisdom that the experience machine, while it neatly disposes of hedonism, poses no problem for desire-based theories of well-being.
Cancer in old age means a complex situation that may differ depending on where in the aging process the person is. For the older patient it is a reminder of that life is going to its end. Cancer treatment is to be provided in addition to handling other health problems and the overall frailty that goes with old age. Comprehensive geriatric assessment and case management may be a way to handle the f
Regional governments in Europe seem to be playing an increasing role in hydrogen and fuel cell (H2FC) development. A number of regions are supporting demonstration projects and building networks among regional stakeholders to strengthen their engagement in H2FC technology. In this article, we will analyse regions that are highly engaged in H2FC activity, based on three indicators: existing hydroge
A beam shift method is presented for an aperture coupled stacked microstrip antenna with a gridded parasitic patch. The gridded parasitic patch is formed by nine close coupled identical rectangular microstrip patches. Each of these patches is resonant at the antenna central frequency. Using four switches connecting adjacent parasitic patches in the grid, it is possible to realize a pattern reconfi
Several severe fires in structural elements, or so-called "structural fires", have occurred in Sweden in recent years. In order to study this phenomenon, a dozen fires in structural elements have been studied in a recent project. This paper provides a description of the characteristics of "structural fires" and examples of how such events can be managed and limited. Constructional fire protection,
