The saddle point approximation of Rice's formula for the upcrossing rate of a stationary random process has until now only been informally studied. We formulate and prove a formal theorem which gives the first two terms in the saddle point expansion and slightly modify the second term.

Background/Objectives:Dietary addition of either conjugated linoleic acid (CLA) or n-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFAs) has been shown to alter adiposity and circulating lipids, risk markers of cardiovascular diseases. However, CLA may decrease insulin sensitivity, an effect that may be reversed by n-3 LC-PUFA. Thus, the potential of CLA plus n-3 LC-PUFA to affect insulin secr

BACKGROUND:: Patients with chronic heart failure (HF) and their partners face many challenges associated with heart disease. High social support in a close relationship has been found to improve survival in patients with HF. However, caring for a patient with HF may have negative effects on the health-related quality of life (HRQOL) of the partner responsible for the care. The main focus in health

What is Church archaeology today, and what would we like it to be tomorrow? The occasion of the 90-year birthday of professor emeritus Erik Cinthio has afforded me the opportunity to reflect upon these two questions. Departure is taken in the 19th century, when medieval churches first became a topic of interest for researchers and architects. Church archaeology developed as a sub-discipline of art

This paper argues for the importance of using the regional innovation systems (RIS) approach as both an analytical framework and a policy tool for generating economic development in developing countries. The paper reconceptualizes the RIS-model to the context of developing countries. RIS is normally based on endogenous growth models; however, in this paper we extend it to rely on external capital,

Alterations in the expression and signalling pathways of vascular endothelial growth factor (VEGF) have been linked to the clinical features and pathogenesis of hematologic malignancies. In this study, we showed that VEGF protein expression was statistically significantly higher in the leukemic blasts than in the normal hematopoietic counterparts. A statistically significant correlation between ex

In efforts to find synergies or trade-offs between the environmental and social pillars of policies aimed at sustainable development, a key set of issues are often discussed in terms of geographical scale. The aim of this paper is to critically examine the framings of social and environmental sustainability challenges as scale-related (such as local - global or North-South) involved in processes i

Investigation of the differential operators with the generalized coefficients having singular support on a disjoint set of points requires the consideration of the distribution theory with the set of discontinuous test functions. Such a distribution theory for test functions having discontinuity at one point is developed. A four-parameter family of Schrodinger operators, formed by the operators wi