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Pancreatic beta-cells secrete insulin by Ca2+-dependent exocytosis of secretory granules. beta-cell exocytosis involves SNARE (soluble NSF-attachment protein receptor) proteins similar to those controlling neurotransmitter release and depends on the close association of L-type Ca2+ channels and granules. In most cases, the secretory granules fuse individually but there is ultrastructural and bioph
Strategic change, infused with new data, perspectives and concepts may change the inherent meaning of the central tenets in an existing strategy. It taps into the cognitive aspects of a journey where language, in verbal and written form, aids in the process of communicating, understanding and creating new meaning. Hence, it comes as no surprise that communication is argued to be an important means
OBJECTIVE The long-term association between dietary protein and type 2 diabetes incidence is uncertain. We aimed to investigate the association between total, animal, and plant protein intake and the incidence of type 2 diabetes. RESEARCH DESIGN AND METHODS The prospective European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct case-cohort study consists of 12,403 incident typ
Rewetting a dry soil can result in two response patterns of bacterial growth and respiration. In type 1, bacterial growth starts to increase linearly immediately upon rewetting and respiration rates are highest immediately upon rewetting. In type 2, bacterial growth starts to increase exponentially after a lag period with a secondary increase in respiration occurring at the start of the exponentia
Purpose: Flattening filter free (FFF) beams generated by medical linear accelerators have recently started to be used in radiotherapy clinical practice. Such beams present fundamental differences with respect to the standard filter flattened (FF) beams, making the generally used dosimetric parameters and definitions not always viable. The present study will propose possible definitions and suggest
Context Preterm birth is the leading cause of infant mortality in developed countries, but the association between gestational age at birth and mortality in adulthood remains unknown. Objective To examine the association between gestational age at birth and mortality in young adulthood. Design, Setting, and Participants National cohort study of 674 820 individuals born as singletons in Sweden in 1
Preeclampsia (PE) complicates 3-8% of all pregnancies and manifests clinically as hypertension and proteinuria in the second half of gestation. The pathogenesis of PE is not fully understood but recent studies have described the involvement of cell-free fetal hemoglobin (HbF). Hypothesizing that PE is associated with prolonged hemolysis we have studied the response of the cell-free Hb- and heme de
We tested how dispersal capacity, host plant specificity and reproductive rate influenced the effects of farming system and landscape composition on butterfly species richness and abundance. In no case did variation in these traits explain species responses to organic farming, indicating that all species benefit equally. In contrast, butterflies with high mobility and reproductive rate were dispro
We sought to determine the influence of single-nucleotide polymorphisms (SNPs) in RANKL, RANK, and OPG on volumetric bone mineral density (vBMD) and bone geometry at the radius in men. Pairwise tag SNPs (r (2) a parts per thousand yen 0.8) for RANKL (n = 8), RANK (n = 44), and OPG (n = 22) and five SNPs near RANKL and OPG strongly associated with areal BMD in genomewide association studies were pr
Introduction. The study is part of a project in which young women’s evaluation of information sources before choosing a contraceptive is studied. It focuses on young women meeting midwives for counselling about contraceptives. Conversations are information literacy practices with both parties negotiating about needed and appropriate information on which they will base decisions. Method. Ten conve
An overview of the integration of the Skåne provinces into the Swedish state after 1658, showing that it was done in a way typical of the 17th century European conglomerate states.
The thesis describes aspects of left ventricular systolic and diastolic function examined with echocardiography in patients with systemic inflammation and shock. Background: Myocardial depression is a well-known complication in critically ill patients with shock. Echocardiography is increasingly used for assessing left ventricular (LV) function in these patients. Aims: 1) To describe the feasibili
Introduction: Human body acceleration is often used as an indicator of daily physical activity in epidemiological research. Raw acceleration signals contain three basic components: movement, gravity, and noise. Separation of these becomes increasingly difficult during rotational movements. We aimed to evaluate five different methods (metrics) of processing acceleration signals on their ability to
Tourist research on life in "The Experience Economy" has led to a focus oil the eventful cold dramatic, on ways of packaging and marketing "great experiences" that turn a heritage into all event, a city into desires, a museum into all adventure. There is a lot of talk about the production of great atmospheres and exciting events, but tourist life is of course full of non-events, indifferent or bad
The kallikrein gene family (KLK1-KLK15) is the largest contiguous group of protease genes within the human genome and is associated with both risk and outcome of cancer and other diseases. We searched for copy number variants in all KLK genes using quantitative PCR analysis and analysis of inheritance patterns of single nucleotide polymorphisms. Two deletions were identified: one 2235-bp deletion
The micro-mechanisms of fracture in a laminate composed of an aluminium foil and a polymer film are considered in this study. The laminates as well as the individual layers, with and without premade centre-cracks, were tensile tested. Visual inspection of the broken cross-sections shows that failure occurs through localised plasticity. This leads to a decreasing and eventually vanishing cross-sect
In this paper, we investigate the possibility of using accurate prediction models for the prediction of protoporphyrin bleaching dynamics to achieve photobleaching-insensitive methods to improve the evaluation of data in an existing clinical fluorescence-guided resection technique. To simulate the scenario, measurements were carried out in vivo on skin of healthy volunteers using a compact fiber-b
Paraphrasing Slavoj Zizek (1991: 65), the paper proposes that: 'The Scania Truck does not exist': it is nothing but 'the symptom of passionate users', its power of fascination masks the void of its nonexistence'. Along the same line of reasoning, it argues, again paraphrasing Zizek, that 'the customized Scania truck is becoming the sinthome of its user'. (c.f. Zizek, 1991: 137). The paper does so
