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Social genetic effects for drug use disorder among spouses

Aims: Preclinical and human studies suggest that a social partner's genotype may be associated with addiction-related outcomes. This study measured whether spousal genetic makeup is associated with risk of developing drug use disorder (DUD) during marriage and whether the risk associated with a spouse's genotype could be disentangled from potentially confounding rearing environmental effects. Desi

Optimization of Aeration Diffuser System Design : A Simulation Study

The influence of aeration diffuser system design on electricity usage, effluent water quality, and life-cycle cost in biological wastewater treatment was investigated. A plant-wide model was implemented, and simulations were carried out with different process configurations and aeration systems. Model-aided design of new aeration diffuser systems could significantly decrease electricity usage and

Modelling and numerical simulation of remodelling processes in cortical bone : An IGA approach to flexoelectricity-induced osteocyte apoptosis and subsequent bone cell diffusion

Remodelling is an important process in bones in order to maintain bone mass and to recover cracks which naturally develop within the bone material. There is agreement in the literature that the piezoelectric characteristic of bones is one possible initiator of bone remodelling. In recent experimental studies, however, it has been found that cortical bone also exhibits flexoelectric properties whic

The use of multi-zone modelling for tunnel fires

This paper introduces the use of a multi-zone modelling approach for analysing smoke spread in tunnels. The approach suggested in this paper is based on an existing model, i.e., the Multi-Zone Fire model developed for large spaces. The Multi-Zone Fire model has been adapted and modified for tunnel fire scenarios by including features that consider longitudinal ventilation flow, tunnel gradient and

Tendency of soil erosion dynamics by coupling radioisotopes and RUSLE model on the Southeastern Tibetan Plateau in response to climate warming and human activity

Soil erosion has created landscape problems in many parts of the world and in particular in cold regions where the sensitive permafrost conditions have changed due to climate warming. Such a case occurred in the Tibetan Plateau (TP), which has been strongly affected by global warming and human activities. Monitoring technologies, like remote sensing and field surveys were used to explore soil eros

Dorsal anterior cingulate cortex activity during cognitive challenge in social anxiety disorder

Background: Social anxiety disorder (SAD) is associated with aberrant emotional information processing while little is known about non-emotional cognitive processing biases. The dorsal anterior cingulate cortex (dACC) has been implicated in SAD neuropathology and is activated both by emotional and non-affective cognitive challenges like the Multisource Interference Task (MSIT). Methods: Here, we u

Large-bias spectroscopy of Yu-Shiba-Rusinov states in a double quantum dot

We have performed tunnel transport spectroscopy on a quantum dot (QD) molecule proximitized by a superconducting contact. In such a system, the scattering between QD spins and Bogoliubov quasiparticles leads to the formation of Yu-Shiba-Rusinov (YSR) states within the superconducting gap. In this work, we investigate interactions appearing when one- and two-electron spin states in a double-QD ener

Burden of established cardiovascular disease in people with type 2 diabetes and matched controls : Hospital-based care, days absent from work, costs and mortality

Aims: To assess hospital-based care, work absence, associated costs, and mortality in patients with type 2 diabetes with and without established cardiovascular disease (eCVD) compared to matched controls. Materials and methods: In a population-based cohort study, we analysed individual-level data from national health, social insurance and socio-economic registers for people diagnosed with type 2 d

Design, synthesis, And applications of galectin modulators in human health

Over the last decade, the family of galectin proteins has been identified as key regulators of important biological processes. They bind β-D-galactopyranoside residues in glycoconjugates, and by presenting multiple binding sites, within one galectin or by forming dimers or multimers, they can cross-link glycoproteins and form galectin-glycoprotein lattices. Such lattices formed on the cell surface

Surface characterization and analysis of textured injection moulded PC-ABS automotive interior components

Automotive interior components are produced by injection moulding due to its cost effectiveness in mass production. The surfaces of these components are textured to control the appearance and other surface functional properties such as wear and scratch resistance. Key challenges lie in replicating the features of mould tool with high aspect ratio which are influenced by the polymer and large numbe

A dose planning study for cardiac and lung dose sparing techniques in left breast cancer radiotherapy : Can free breathing helical tomotherapy be considered as an alternative for deep inspiration breath hold?

Purpose: To investigate the possibility to be able to offer left sided breast cancer patients, not suitable for DIBH, an organ at risk saving treatment. Materials and Methods: Twenty patients receiving radiotherapy for left breast cancer in DIBH were enrolled in the study. Planning CT scans were acquired in the same supine treatment position in FB and DIBH. 3DCRT_DIBH plans were designed and optim

Lignin recovery from cocoa bean shell using microwave-assisted extraction and deep eutectic solvents

Lignin is the second most abundant natural polymer after cellulose, and valorisation of lignin-rich streams has attracted increasing attention recently. This paper presents a novel and sustainable method to recover lignin from Cocoa Bean Shells (CBS) using Deep Eutectic Solvents (DES) and microwaves. A DES containing p-toluenesulfonic acid, choline chloride and glycerol (2:1:1 M ratio) was selecte

Second-hand clothing markets and a just circular economy? Exploring the role of business forms and profit

Second-hand consumption of clothing can support the transition to circular economies by prolonging the lifespan of products through reuse. Historically, not-for-profit businesses have been dominant actors in second-hand markets across Western Europe and North America. However, with the growing interest in second-hand consumption, for-profit firms have increasingly entered this market over the last

Isothiazolinone inhibition of soil microbial activity persists despite biocide dissipation

Soil microbial growth and activity are generally assumed to recover rapidly after dissipation of organic toxicants. We studied the effects of four readily degradable isothiazolinone biocides (benzisothiazolinone, BIT; methylisothiazolinone, MIT; octylisothiazolinone, OIT; 4,5-dichloro-2-octyl-isothiazolinone, DCOIT) on bacterial growth, fungal growth, basal respiration, and substrate-induced respi

The characteristics of Michelin-starred restaurants in Mainland China, Hong Kong, Macau, and Taiwan

Chinese culinary culture has a long history of development and has unique characteristics, attracting people from all over the world. As a world-renowned restaurant award, the Michelin Guide in China plays an influential role in introducing Chinese culinary culture to the world and destination branding, while few studies have investigated Michelin-starred restaurants (MSRs) in China. This study th

Spatial inequality and housing in China

This paper investigates the evolution of inequality in China (1978–2015) through the lens of a dynamic spatial general equilibrium model with migration and capital formation. Due to an urban-rural income gap there is domestic migration from the rural to the urban areas which tends to reduce inequality. The resulting increase in urban house prices can, however, constitute an endogenous barrier to f

Application of a Magnetic-field-induced Transition in Fe x to Solar and Stellar Coronal Magnetic Field Measurements

Magnetic fields play a key role in driving a broad range of dynamic phenomena in the atmospheres of the Sun and other stars. Routine and accurate measurements of the magnetic fields at all the atmospheric layers are of critical importance to understand these magnetic activities, but in the solar and stellar coronae such a measurement is still a challenge due to the weak field strength and the high

An explorative study of inflammation-related proteins associated with kidney injury in male heat-stressed workers

Chronic kidney disease of non-traditional origin (CKDnt) and acute kidney injury (AKI) often affect heat-stressed Mesoamerican manual workers. Inflammation occurs concurrently with AKI in this population, but its role remains unknown. To explore links between inflammation and kidney injury in heat stress, we compared levels of inflammation-related proteins in cutters with and without increasing se