Objectives: Adverse pregnancy outcomes are more common in women with SLE compared with healthy women, but we lack prognostic biomarkers. Plasma IFN-α protein levels are elevated in a subgroup of pregnant women with SLE, but whether this is associated with pregnancy outcomes is unknown. We investigated the relationship between IFN-α, adverse pregnancy outcomes and the presence of autoantibodies in

In this study, we investigated the impact of bariatric surgery on the adipose proteome to better understand the metabolic and cellular mechanisms underlying weight loss following the procedure. A total of 46 patients with severe obesity were included, with samples collected both before and after bariatric surgery. In addition, 15 healthy individuals without obesity who did not undergo surgery serv

Soils are among Earth’s most vital yet slowly renewable natural resources. Chernozem stands out as the most fertile soil globally, capable of yielding high agricultural productivity, and it continues to play a significant role in modern agriculture. The Vojvodina region of Serbia is renowned for its fertile soil, including Chernozem. This study aims to evaluate the current condition and geotourism

The ubiquitous use of plastics demands thoughtfulness about their fate in the environment. Biodegradability is, therefore, a prerequisite for the future use of plastics in many applications, including agriculture. Here, we bring forward stable isotope (resonance) Raman microspectroscopy at the single-cell level to broaden the mechanistic understanding of microbial degradation of (micro)plastics in

Background: Out-of-hospital cardiac arrest (OHCA) survivors and their relatives may face challenges following hospital discharge, relating to mood, cognition, and returning to normal day-to-day activities. Identified research gaps include a lack of knowledge around what type of intervention is needed to best navigate recovery. In this study, we investigate the feasibility and patient acceptabilityBackground: Out-of-hospital cardiac arrest (OHCA) survivors and their relatives may face challenges following hospital discharge, relating to mood, cognition, and returning to normal day-to-day activities. Identified research gaps include a lack of knowledge around what type of intervention is needed to best navigate recovery. In this study, we investigate the feasibility and patient acceptability

There are four paths to a Swedish medical license. A shared agreement exists for those converting from a European license to recognize qualifications granted in the respective countries mutually. Swedish medical graduates and International Medical Graduates (IMGs) trained outside the EU/EES/Schweiz are assessed against the professional qualifications specified in the Higher Education Ordinance (19

A repulsively interacting Bose-Einstein condensate on a ring is well known to show persistent currents. For attractive interactions, however, a bound state may form that renders the rotation classical. Here we show that in a multiply connected confinement, the strong in-plane attraction of an antidipolar condensate can form stacks of ring-shaped density lumps which may coherently overlap to form a

CRISPR-mediated gene activation (CRISPRa) encompasses a growing field of biotechnological approaches with exciting implications for gene therapy. However, there is a lack of experimental validation tools for selecting efficient sgRNAs for downstream applications. Here, we present a screening assay capable of identifying efficient single- and double sgRNAs through fluorescence quantification in vit

Albeit costly, flight allows birds to travel great distances in a short time, making it a highly effective mode of locomotion, especially during migration.1,2 Understanding how birds use energy during flight is essential for studying their flight ecology.3 To fly, birds flap their wings, accelerating surrounding air and generating flight forces, where the rate of energy added to the wake represent

Background Monitoring labor and childbirth, early recognition, and treatment of complications are critical for preventing adverse birth outcomes. However excessive use of interventions during labor has not been demonstrated to enhance subsequent birth outcomes and may, in fact, pose a risk of harm. The World Health Organization has recently synthesized research from the last decade concerning labo

Objectives We aimed to compare various methods for imputing disease activity in longitudinally collected observational data of patients with axial spondyloarthritis (axSpA). Methods We conducted a simulation study on data from 8583 axSpA patients from ten European registries. Disease activity was assessed by the Axial Spondyloarthritis Disease Activity Score (ASDAS) and the corresponding low disea

I pendeltågstrafiken körs ibland tåg med färre vagnar än normalt (så kallade korta tåg). Detta kan påverka hur passagerarna sprider ut sig på plattformen och hur snabbt påstigningen går. Syftet med detta examensarbete är att undersöka effekten av reseinformation om korta tågsammansättningar (tåg med 4 dörrar) på passagerares beteende på plattformen och påstigningstider, med fokus på Lunds centralsIn commuter train traffic, trains sometimes run with fewer carriages than normal (short trains). This can affect how passengers spread out on the platform and how quickly they can board. The purpose of this thesis is to investigate how travel information about short train formations (trains with 4 doors) affects passenger behavior on the platform and boarding times. The study focuses on Lund Centr

Introduction: Achieving and retaining a low background signal is essential for analytical techniques, especially for extremely accurate systems such as supercritical fluid chromatography (SFC) coupled with high-resolution mass spectrometry (HRMS) since the limits of detections are heavily dependent on the background signal. Background: A standard option to ensure a low background signal is the usa

Byggbranschen är i dagsläget en av de störst bidragande faktorerna till utsläpp av fossila bränslen i Sverige och besitter en stor utvecklingspotential beträffande reducering av klimatpåverkan. En byggnads klimatpåverkan under en livscykel kan beräknas genom metoden livscykelanalys, som inkluderar en produkts, eller i detta fall en byggnads, klimatpåverkan från råvaruutvinning till avfallshanterinThe construction industry is currently one of the largest contributing sources to carbon dioxide emissions in Sweden and has great development potential in reducing its climate impact. Since January 2022, the Swedish government requires a declaration of the climate impact of each recently constructed building. To calculate the climate impact of a building, the life cycle assessment tool is used, a

För kemister världen över är neurologiska och psykiatriska sjukdomar viktiga forskningsområden. Den ökande efterfrågan på läkemedel som kan hjälpa mot dessa sjukdomar är en växande utmaning. Därför har vi i detta projekt valt att arbeta med en typ av receptor i hjärnan som är involverad i många av dessa sjukdomar, nämligen NMDA-receptorer. Man kan jämföra NMDA-receptorer med de tre skandinaviska sNMDA receptors are ligand-gated ion channels assembled as heterotetramers composed of glycine-binding GluN1 and GluN3 subunits (GluN3A-B), and glutamate-binding GluN2 subunits (GluN2A-D). Their involvement in various psychiatric and neurological disorders makes them potential therapeutic targets. However, compared to the extensively studied GluN1/2 NMDARs, the functional, physiological, and pharma

As Sweden expands and modernizes its railway network, the design of durable and cost- efficient railway bridges becomes increasingly important. A central technical challenge in this context is track-bridge interaction (TBI), the mechanical interplay between the rail and bridge structure. This interaction affects how forces from traffic loads, temperature variations and braking are transferred with