The last decade has witnessed a revolution in genetic technology, where genome-wide analyses, covering the majority of genetic variation, were thought to explain disease-causing mechanisms in common metabolic disorders. However, these genetic data only explain a modest proportion of the estimated heritability of type 2 diabetes and obesity and hence suggest a potential role for epigenetic variatio

Yuknessia Walcott, 1919 recently was transferred from the green algae to the Phylum Hemichordata on the basis of new details observed for the type species, Y. simplex, from the Burgess Shale Formation (Cambrian Stage 5) of British Columbia. This has prompted reexamination of material attributed to Yuknessia from various Cambrian localities in South China. Findings preclude both a Yuknessia and a h

Exceptionally preserved specimens of the Cambrian stem-group brachiopod Mickwitzia occidens Walcott, 1908 are described in detail from the Indian Springs Lagerstatte in Nevada, USA. Shell structure and preserved mantle setae from these specimens reveal a variable diagenetic (taphonomic) history and provide insight into the phylogenetic position of mickwitziids. Morphologic and morphometric compari

Policies and strategies to fight global environmental degradation, gender inequality, and poverty are often inadequate, ineffective, or insufficient. In response, this article seeks potential synergies and leverage points between three significant interrelated discourses that are often treated separately—development, gender, and environment. Proceeding from a brief history of development thinking

Glioma cells with stem cell traits are thought to be responsible for tumor maintenance and therapeutic failure. Such cells can be enriched based on their inherent drug efflux capability mediated by the ABC transporter ABCG2 using the side population assay, and their characteristics include increased self-renewal, high stem cell marker expression and high tumorigenic capacity in vivo. Here, we show

Metformin lowers diabetic blood glucose primarily by reducing hepatic gluconeogenesis and increasing peripheral glucose uptake. However, possible effects by metformin on beta-cell function are incompletely understood. We speculated that metformin might positively influence insulin secretion through impacting the beta-cell nitric oxide synthase (NOS)-NO system, a negative modulator of glucose-stimu

Objectives: The Joint United Nations Programme on HIV/AIDS (UNAIDS)/World Health Organization (WHO) 90-90-90 goals propose that 90% of all people living with HIV should know their HIV status, 90% of those diagnosed should receive antiretroviral therapy (ART), and 90% of those should have durable viral suppression. We have estimated the continuum of HIV care for the entire HIV-1-infected population

Metabolic crisis is a clinical condition primarily affecting patients with inherent mitochondrial dysfunction in situations of augmented energy demand. To model this, ten pigs received an infusion of rotenone, a mitochondrial complex I inhibitor, or vehicle. Clinical parameters, blood gases, continuous indirect calorimetry, in vivo muscle oxygen tension, ex vivo mitochondrial respiration and metab

Identification and relative quantification of hundreds to thousands of proteins within complex biological samples have become realistic with the emergence of stable isotope labeling in combination with high throughput mass spectrometry. However, all current chemical approaches target a single amino acid functionality (most often lysine or cysteine) despite the fact that addressing two or more amin

The general objective of this thesis was to increase the knowledge of how mental health and school performance are associated and how interventions may be designed and implemented to enhance the two.The data used in the four quantitative studies on which this thesis is based were derived from two age cohorts of students attending 14 elementary schools in two cities in the southern part of Sweden.

This dissertation examines the changing time allocation of men and women at the turn of the 21st century in Sweden, an interesting case given its strong position concerning female labor force participation, maternal employment, and gender equality. The aim is to examine to what extent gender and parenthood affect various types of time allocation, both in the labor market and household, and provide

Abstract The chemistry of CO and D2O, individually adsorbed or co-adsorbed, on epitaxial thin films of samaria on Pt(111) was studied by temperature-programmed desorption spectroscopy (TPD). Continuous thin films as well as discontinuous films composed of samaria islands on bare Pt(111) were prepared. Their comparative study indicates that Sm2O3 islands provide lattice oxygen at their perimeter fo

The rugged field and group of trees between housing estates or next to the railroad tracks, the left-over space of deserted industrial areas, the vacant demolition site of a central city block – they could all be termed ‘urban voids’. However, they are often anything but voids, in a literal sense, as they are not empty, or deserted. Yet they are ‘urban voids’, lacking an evident function, or a def

Climate change is expected to cause extensive vegetation changes in the Arctic: deciduous shrubs are already expanding, in response to climate warming. The results from transect studies suggest that increasing shrub cover will impact significantly on the surface energy balance. However, little is known about the direct effects of shrub cover on permafrost thaw during summer. We experimentally quan

In recent years, we have seen the development of a more relational approach to territoriality. This perspective, which focuses on events rather than space, also opens up for an elaboration of temporal aspects of territorial production. In this study, I investigate the central urban square, Stortorget, in Malmö, Sweden, in order to develop a discussion of a time-space territorology. In 1978, Korose

Aerosol particles affect Earth’s climate system by scattering and absorbing light. The perturbation of the climate system caused by a change in aerosol configuration due to anthropogenic emissions has recently improved. However, the radiation balance and hydrological cycle of Earth are also highly influenced by clouds: a small change in cloud configuration can have a large effect on the climate. C