Use of nonlinear upconverting nanoparticles provide increased spatial resolution in fluorescence diffuse imaging
Fluorescence diffuse imaging suffers from limited spatial resolution. In this letter, we report a scanning imaging approach to increase the resolution of fluorescence diffuse imaging using nonlinear fluorophores. The resolution of a linear flurophore was compared with nonlinear upconverting nanoparticles (NaYF4 : Yb3+ /Tm3+ ) in a tissue phantom. A resolution improvement of a factor of 1.3 was fou
