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Objective Transcriptomic subtyping is not yet standardized for prognostic use in epithelial ovarian cancer (EOC). This study aims to validate RNA sequencing (RNAseq) from formalin-fixed, paraffin-embedded (FFPE) tissues and to evaluate survival-associated transcriptomic subtypes and differentially expressed genes (DEGs) in a clinical trial cohort. Methods An exploratory post hoc analysis was condu
INTRODUCTION: Resection of intraductal papillary mucinous neoplasm (IPMN) aims to prevent progression to invasive pancreatic cancer. However, the risks of pancreatic surgery and frequent findings of low-grade dysplasia (LGD) raise concerns about overtreatment. This EAHPBA-endorsed multinational study evaluated short- and long-term overall survival (OS) following preventive resection for IPMN (with
Climate change is recognized as one of the greatest environmental threats facing the world today. To tackle this problem, a protocol was adopted in Kyoto in 1997 which establishes legally binding commitments to developed countries to bring down the emissions of six major greenhouse gases by 5.2% compared to the year 1990. Three flexibility mechanisms have been provided to developed countries to ac
Women constitute a minority among patients in forensic psychiatric care, which aims to improve the patients’ health while ensuring safety for patients, caregivers, and society. Participation in forensic psychiatric care can be complex; its definition depends on the context and perspective and is influenced by several factors. This study examined the perceptions of female patients and caregivers re
During periods of economic and social stability, retailers rarely need to address grocery hoarding. However, in times of crises, understanding the driving mechanisms behind hoarding becomes crucial. This study investigates the relationship between consumers’ personality traits and grocery hoarding in Sweden during the beginning of Covid-19, applying the Five-Factor Model of personality (FFM), whic
This paper presents a two-phase heuristic methodology aimed at the reconfiguration of a radial distribution network with the objective of minimizing the computational time. In the preliminary phase of the operation, all network switches are in a closed state, and it is proposed that a subsequent switch opening methodology be employed to achieve a configuration that approximates optimal radial char
We present iHOMER, an iterative version of the HOMER method to extract Lund fragmentation functions from experimental data. Through iterations, we address the information gap between latent and observable phase spaces and systematically remove bias. To quantify uncertainties on the inferred weights, we use a combination of Bayesian neural networks and uncertainty-aware regression. We find that the
The European land carbon uptake has been heavily impacted by several recent severe droughts, yet quantitative estimates of carbon uptake anomalies are uncertain. Atmospheric CO2 inverse models (AIMs) provide observation-based estimates of the large-scale carbon flux dynamics, but how well they capture drought impacts on the terrestrial carbon uptake is poorly known. Here we assessed the capacity o
For many years, car antennas of various applications are co-integrated into the roof-mounted “shark fin” module. More recently, both hidden antennas and full glass roofs are becoming trendy in the car industry. Taken together, they point to the integration of car antennas into glass roof being an attractive car antenna solution. However, such a solution is challenging to realize due to the roof gl
This timely book presents new perspectives from global experts in entrepreneurship, innovation and regional economic development. Bringing together diverse perspectives, Eleanor Hamilton, Rhiannon Pugh and Danny Soetanto integrate research, practice and policy to develop new ideas and propose innovative learning models.
Notch connections are commonly used in timber concrete composite (TCC) members because of the simple geometry of the solution making execution easy and the high strength and stiffness resulting from the mechanical interlock between the timber and concrete. However, the use of low strength lightweight concrete in TCC applications is limited in the literature. Therefore, in this work, shear tests we
This study examines the contribution of a structural glass window integrated into a lightweight timber-frame wall diaphragm at the structural level. A full-scale timber mock-up, comprising different bracing elements such as wall diaphragms (with and without a bonded structural window), and a moment-resisting frame, combined with a roof diaphragm, was subjected to multiple serviceability limit stat
This study aimed to evaluate the clinical acceptability of artificial intelligence (AI)-based organ segmentations on pretreatment CT images of prostate cancer patients using manual organ delineations as a reference. Paired AI-based segmentations and manual delineations of the prostate, urinary bladder, and rectum were evaluated by three observers, according to a 4-grade Likert-scale, based on qual
In the past decades, the number of research work explaining the load transfer mechanism of moment connections has increased due to their advantages of energy dissipation capacity and improved load distribution. The use of bolts in slotted-in plate moment connections is a common practice in timber construction. However, the design and application guidelines are still limited and leading to results
This chapter investigates how the challenging questions and tensions caused by migrants and their universalist claims for inclusion, have been approached and resolved in liberal democracies. By regarding the development of populism as a real and dangerous political phenomenon that has significant traction, the chapter asks whether populism adds something new to this approach and resolution. More s
Air pollution has been linked to reduced birthweight, but the association with black carbon (BC) remains insufficiently explored. This study examined the association of gestational exposure to BC with birthweight outcomes. We included data on all singleton births in Denmark between 2004 and 2016 (n = 690,898). BC and fine particulate matter (PM2.5) were estimated by high-resolution air pollution m
Firm innovation is strongly shaped by regional endowment – defined here as regional supply- and demand-side conditions for innovation – yet many regions are disadvantaged by having low levels of such endowment. While recent research increasingly emphasizes the role of regional soft factors, such as psychological openness, we still know relatively little about how such factors influence firm innova
