A role of the immune system in Parkinson’s disease (PD) progression has long been suspected due to the increased frequency of activated glial cells and infiltrating T cells in the substantia nigra. It was previously reported that PD donors have increased T cell responses towards PINK1 and α-synuclein (α-syn), two Lewy body-associated proteins. Further, T cell reactivity towards α-syn was highest c

Background: Lower limb deep vein thrombosis (DVT) is common in emergency departments (EDs) and can be fatal if left untreated due to the risk of progression to pulmonary embolism (PE). In Scandinavia, DVT diagnosis typically relies on ultrasound performed outside the ED in the diagnostic departments. However, international guidelines now recommend combining limited/proximal compression ultrasound

Characterizing subtle cognitive changes in preclinical Alzheimer’s disease (AD) is difficult using traditional neuropsychological assessments. Remote and unsupervised digital assessments can improve scalability, measurement reliability, and ecological validity, enabling the capture of subtle changes. We evaluate such tools for use in preclinical AD, or cognitively unimpaired individuals with abnor

Functional MRI (fMRI) using the blood-oxygen level dependent (BOLD) signal provides valuable insight into grey matter activity. However, uncertainty surrounds the white matter BOLD signal. Apparent diffusion coefficient (ADC) offers an alternative fMRI contrast sensitive to transient cellular deformations during neural activity, facilitating detection of both grey and white matter activity. Furthe

TAR DNA-binding protein 43 (TDP-43) pathology is linked to the neurodegenerative disorders amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD) and Huntington disease (HD). Dysregulation of metabolism and emotion is shared across these disorders and may be caused by hypothalamic pathology. Inclusions with TDP-43 are present in the hypothalamus in clinical ALS, as well as selective lo

Background: Coronavirus disease 2019 (COVID-19) pandemic constituted the largest global health crisis in recent generations. It may also have disrupted the pattern of antimicrobial use (AMU) and subsequently affected the development of antimicrobial resistance (AMR) – a grave human health concern. This study aimed to give an overview of existing AMR surveillance systems and evaluate the impact of

Luminescent properties of KTb(MoO4)2 and K5Tb(MoO4)4 crystals, possessing the same elemental composition but different crystal structures, were studied. The structural arrangement of Tb3+ ions, ordered in KTb(MoO4)2 and disordered in K5Tb(MoO4)4, determines their luminescence properties. Partial lattice disorder of K5Tb(MoO4)4 results in broadened bands of Tb3+ emission and excitation spectra, but

In Sweden, the pedagogical training of doctoral students varies significantly across universities. While most institutions include at least one mandatory course in higher education teaching and learning, some programs lack this requirement entirely. Whether doctoral students are encouraged or even allowed to take multiple pedagogical courses also varies greatly. This paper explores the benefits ofIn Sweden, the pedagogical training of doctoral students varies significantly across universities. While most institutions include at least one mandatory course in higher education teaching and learning, some programs lack this requirement entirely. Whether doctoral students are encouraged or even allowed to take multiple pedagogical courses also varies greatly. This paper explores the benefits of

Depressive and anxiety disorders are leading causes of disability globally. Therapist-guided, Internet-delivered cognitive behaviour therapy (ICBT) is an established treatment for depression and anxiety, but a considerable proportion of treated patients do not achieve sufficient improvement. Predicting symptom changes based solely on clinical variables is challenging, and genetic data could offer

Contact allergy (CA) is not uncommon in the population, including to various fragrance allergens. If not diagnosed correctly, allergic contact dermatitis (ACD) may ensue, because targeted allergen avoidance is not possible. The primary objective of the study is to estimate the prevalence of CA to seven fragrance materials in patients with suspected ACD across Europe. Based on the outcome, a conclu

Background: Eating disorders significantly impact physical health and have negative psychosocial consequences. The global burden of anorexia nervosa and bulimia nervosa among young females is estimated to account for 1.9 million disability-adjusted life years. Early identification of disordered eating attitudes is critical for preventing the progression to more severe forms of eating disorders; ho

De kristnas historia i Mellanöstern under tvåtusen år.

Svenskt 1600-tal Stormaktstiden Reseberättelse franska resenärer

Romantik Idéhistoria filosofi Sekelskiftet 1800 Jena