Råttan är en däggdjursart med en kort dräktighetstiden och föds därför mycket omogen. Den är vid födelsen naken, blind och döv och är helt beroende av sin moder för många funktioner, såsom näringstillförsel, termoreglering, urinering och tarmtömning. Under diperioden är råttans mag-tarmsystem och matsmältning helt anpassad till modersmjölkdieten. Bland annat är tarmens barriärfunktion omogen, vilkThe rat, as an altritial species, is born with an immature gastrointestinal tract and intestinal barrier function, which is highly absorptive to milk-borne bioactive molecules that can pass undigested and reach the general circulation of the suckling newborn. This passage occurs by the neonatal-Fc-receptor (FcRn) binding and trancytosis of immunoglobulin G in the proximal small intestine (SI) and

Populärhistorisk översikt över relationerna mellan Lunds universitet och svenska monarker (och en kronprins) vid namn Carl från Carl X Gustaf till Carl XVI Gustaf.

BACKGROUND: We sought to identify potential clinical variables associated with outcomes after radium-223 therapy in routine practice. METHODS: Consecutive non-trial mCRPC patients who received ≥1 dose of radium dichloride-223 at four academic and one community urology-specific cancer centers from May 2013 to June 2014 were retrospectively identified. Association of baseline and on-therapy clinical

Varje cell har ett membran som skapar en gräns mot omvärlden och skyddarcellen. Men cellen måste alltjämt utbyta viktiga molekyler med omvärlden för attöverleva. Därför finns specialiserade proteiner, som sitter i membranen och utgörportar i denna barriär. Denna avhandling fokuserar på två membranproteiner, enprotonpump och en jonkanal.Varje dag i våra liv använder vi hjärnan, muskler och hjärtat.NADH:quinone oxidoreductase (Complex I) is the first enzyme of the respiratory chain and is involved in energy conservation generating an electro-chemical gradient across a membrane. The enzyme can be divided into a membrane spanning domain and a hydrophilic domain, which protrudes from the membrane. In the hydrophilic domain electrons from NADH oxidation are transported via a wire of iron-sulfur

Here, I suggest that colour polymorphic study systems have been underutilized to answer general questions about evolutionary processes, such as morph frequency dynamics between generations and population divergence in morph frequencies. Colour polymorphisms can be used to study fundamental evolutionary processes like frequency-dependent selection, gene flow, recombination and correlational selecti

Economic development is full of discontinuities. Mainstream economists perceive these as external disturbances to a natural state of equilibrium, but this book argues that much of the discontinuities are part of economic development, suggesting that patterns can be understood with structural analysis.Structural Analysis and the Process of Economic Development presents a detailed analysis of the tr

Species tropism constitutes a serious problem for developing relevant animal models of infection. Human pathogens can express virulence factors that show specific selectivity to human proteins, while their affinity for orthologs from other species can vary significantly. Suitable animal species must be used to analyse whether virulence factors are potential targets for drug development. We develop

Plants can assimilate nitrogen from soil pools of both ammonium and nitrate, and the relative levels of these two nitrogen sources are highly variable in soil. Long-term ammonium nutrition is known to cause damage to Arabidopsis that has been linked to mitochondrial oxidative stress. Using hydroponic cultures, we analysed the consequences of rapid shifts between nitrate and ammonium nutrition. Thi

Recent experiments have suggested that high energy charge carriers can have a significant effect on the operation of group III nitride (III-N) light-emitting diodes (LEDs), possibly playing an important role in the efficiency droop. As hot carriers are not accounted for by device simulation tools based on drift-diffusion (DD) and quasiequilibrium conditions, more advanced tools are needed. Here, f

In this study, we investigated the ability of Ru(ii) polypyridyl complexes to act as DNA binders. The substitution reactions of three Ru(ii) chlorophenyl terpyridine complexes, i.e. [Ru(Cl-Ph-tpy)(en)Cl]Cl (1), [Ru(Cl-Ph-tpy)(dach)Cl]Cl (2) and [Ru(Cl-Ph-tpy)(bpy)Cl]Cl (3) (Cl-Ph-tpy = 4′-(4-chlorophenyl)-2,2′:6′,2′′-terpyridine, en = 1,2-diaminoethane, dach = 1,2-diaminocyclohexane, bpy = 2,2′-bi

We describe a new technique for automatic identification of stationary, linear systems with a single output. This class of models includes all linear, time-invariant, stochastic, difference equations driven by arbitrary inputs and having stationary, normal disturbances with rational spectra.The parameters of the model are estimated by the method of maximum likelihood. A numerical algorithm for sol

We have formulated and investigated innovative lipid-based nanoparticles characterized by a reverse hexagonal liquid crystalline inner structure (hexosomes). These nanoparticles were doped with a potent, highly water insoluble anticancer drug, namely docetaxel, and stabilized by a mixture of commercial and folate- and rhodamine-conjugated Pluronic F108. Thus, they simultaneously possess therapeuti

We demonstrate how the problem of finding the effective property of quasiperiodic constitutive relations can be simplified to the periodic homogenization setting by transforming the original quasiperiodic material structure to a periodic heterogeneous material in a higher dimensional space. The characterization of two-scale cut-and-projection convergence limits of partial differential operators is

Background: Sodium fluoride (NaF) positron emission tomography combined with computer tomography (PET/CT) has shown to be more sensitive than the whole-body bone scan in the detection of skeletal uptake due to metastases in prostate cancer. We aimed to calculate a 3D index for NaF PET/CT and investigate its correlation to the bone scan index (BSI) and overall survival (OS) in a group of patients w

Maximizing the area under biodiversity-related conservation measures is a main target of the European Union (EU) Biodiversity Strategy to 2020. We analyzed whether agrienvironmental schemes (AES) within EU common agricultural policy, special protected areas for birds (SPAs), and Annex I designation within EU Birds Directive had an effect on bird population changes using monitoring data from 39 far

BACKGROUND: Patients with back and neck pain are often seen in primary care and it is important to provide them with tailored interventions based on risk stratification/triage. The STarT Back Screening Tool (SBT) is a widely used screening questionnaire which has not yet been validated for a population with back and/or neck pain with short duration. Our aim was to compare the concurrent validity o

This paper presents preliminary results for a novel 128-antenna massive Multiple-Input, Multiple-Output (MIMO) testbed developed through Bristol Is Open in collaboration with National Instruments and Lund University. We believe that the results presented here validate the adoption of massive MIMO as a key enabling technology for 5G and pave the way for further pragmatic research by the massive MIM