Aim: Invasive urothelial carcinoma of the bladder (UCB) is characterized by alterations in cell-cycle regulatory pathways. Defects in the expression of cyclin D1, a key cell-cycle regulator, have been implicated in progression of various types of cancer. In the present study, we investigated whether cyclin D1 expression is associated with clinicopathological parameters and whether it has any poten

The truncated hemoglobin from Bacillus subtilis (trHb-Bs) possesses a surprisingly high affinity for oxygen and resistance to (auto)oxidation; its physiological role in the bacterium is not understood and may be connected with its very special redox and ligand binding reactions. Electron transfer reactions of trHb-Bs were electrochemically studied in solution and at graphite electrodes. Spectropho

This paper presents results from a comparative project on the implementation of elder-care in France and Sweden. The transition to requiring care is understood as a process, and elder-care is seen as a part of a more general organisation of social care that reflects different welfare traditions. An overview of elder-care on the institutional level in the two countries is supplemented by case studi

In this paper we analyze how the spatiality of interactions influences trust creation in multi-site corporate innovation projects. By drawing on insights from the discussion on initial and gradual trust in combination with contributions from the field of economic geography, we examine factors influencing the creation of trust and their dependence on face-to-face interaction. We develop a conceptua

OBJECTIVES: Hairdressers often complain of work-related rhinitis (WR). They are infrequently sensitized to persulphates. The cause and mechanism of the symptoms and the effects on their health-related quality of life (HRQoL) remains unclear. The objectives were to follow female hairdressers with WR mainly from bleaching powder regarding nasal reactivity to persulphate and to evaluate symptoms, HRQ

Intralocus sexual conflict (ISC) occurs when males and females have different adaptive peaks but are constrained fromevolving sexual dimorphism because of shared genes. Implications of this conflict on evolutionary dynamics in wild populations have not been investigated in detail. In comprehensive analyses of selection, heritability, and genetic correlations, we found evidence for an ISC over wing

We aimed to identify genetic variants associated with cortical bone thickness (CBT) and bone mineral density (BMD) by performing two separate genome-wide association study (GWAS) meta-analyses for CBT in 3 cohorts comprising 5,878 European subjects and for BMD in 5 cohorts comprising 5,672 individuals. We then assessed selected single-nucleotide polymorphisms (SNPs) for osteoporotic fracture in 2,

In a recent article, David (Tarski’s convention T and the concept of truth, pp. 133–156, 2008) distinguishes between two interpretations of Tarski’s work on truth. The standard interpretation has it that Tarski gave us a definition of truth in-L within the meta-language; the non-standard interpretation, that Tarski did not give us a definition of true sentence in L, but rather a definition of trut

An efficient integral equation based solver is constructed for the electrostatic problem on domains with cuboidal inclusions. It can be used to compute the polarizability of a dielectric cube in a dielectric background medium at virtually every permittivity ratio for which it exists. For example, polarizabilities accurate to between five and ten digits are obtained (as complex limits) for negative

Patients with acute dyspnea are a large heterogeneous patient group where initial management is important for outcome.

Climate data from Empakaai Crater in northern Tanzania, covering the last 1200 years, are related to the establishment, development and decline of the ancient irrigation system at Engaruka. New dates for the system are linked to reconstructed climatic variations and historical data on long-distance and regional trade and migration patterns. A shift from a comparatively humid climate to drier condi

Background and purpose As much as one-third of all total hip arthroplasties in patients younger than 60 years may be a consequence of developmental dysplasia of the hip (DDH). Screening and early treatment of neonatal instability of the hip (NIH) reduces the incidence of DDH. We examined the radiographic outcome at 1 year in children undergoing early treatment for NIH. Subjects and methods All chi

This review of the history of ultraviolet photobiology focuses on the effects of UV-B (280-315 nm) radiation on terrestrial plants. It describes the early history of ultraviolet photobiology, the discovery of DNA as a major ultraviolet target and the discovery of photoreactivation and photolyases, and the later identification of Photosystem II as another important target for damage to plants by UV

This article explores the quest among contemporary pentecostal migrants from mainland Tanzania in Zanzibar to become “saved” Christians. The analysis of a set of techniques and processes applied in developing and keeping faith reveals high levels of suspicion and doubt connected to the perceived presence of evil in the Zanzibari environment, which, in turn, is linked to a fear of losing salvation.

Obesity hypoventilation syndrome (OHS) is often diagnosed late. The aim of this study was to analyse gender differences at initiation of long-term mechanical ventilation (LTMV) in patients with (OHS), to analyse gender differences in treatment effect and to study how the prescription of LTMV due to OHS has changed over time.

In LTE base-stations, RoHC is a processingintensive algorithm that may limit the system from serving a large number of users when it is used to compress the VoIP packets of mobile traffic. In this paper, a hardware-software and a full-hardware solution are proposed to accelerate the RoHC compression algorithm in LTE base-stations and enhance the system throughput and capacity. Results for both sol

Human α-lactalbumin made lethal to tumor cells (HAMLET) and equine lysozyme with oleic acid (ELOA) are complexes consisting of protein and fatty acid that exhibit cytotoxic activities, drastically differing from the activity of their respective proteinaceous compounds. Since the discovery of HAMLET in the 1990s, a wealth of information has been accumulated, illuminating the structural, functional

Various biological tissues are designed to optimally support external loads for complex geometries and mechanobiological structures. This results in complex microstructures of such materials. The design of, for instance, (healthy) arteries, which are in the focus of this work, is characterised by a residually stressed fibre-reinforced multi-layered composite with highly non-linear elastic response

In Meru, Tanzania, changing land/labour ratios have, for over a century, been the main driving force in a farm intensification process. The construction and expansion of irrigation systems, increased use of farm inputs and transfer from low- to high-value agricultural crops have enabled smallholders to improve their land productivity. Technological change has been accompanied by institutional chan

BACKGROUND Genome-wide association studies have identified several genetic loci associated with variation in resting heart rate in European and Asian populations. No study has evaluated genetic variants associated with heart rate in African Americans. OBJECTIVE To identify novel genetic variants associated with resting heart rate in African Americans. METHODS Ten cohort studies participating in th