Många sjukdomar kan kopplas till en svag länk i en av kroppens kemiska reaktionskedjor. En sådan svag länk kan vara ett protein. Ibland går det att lösa problemet genom att ett läkemedel binder in till, likt en nyckel i ett nyckelhål, och stoppar proteinets funktion. Frågan är: vilken molekyl kan binda in till proteinet, och hur? Kunskap om hur en liten molekyl binder in till ett protein är viktiA computational method is described and tested for prediction of ligand-binding poses between the human farnesoid X receptor and a set of 36 potential agonists, provided by the D3R Grand Challenge 2016. Using tools such as Molecular Docking, Molecular Dynamics, Reconnaissance metadynamics and cluster analysis, the method is an attempt to predict the binding pose without being biased by experimenta

Klimatförändringen förväntas orsaka 20-25% kraftigare regnoväder i Sverige vilket, tillsammans med urbaniseringen, ökar sannolikheten för översvämningar i urbana områden. En översvämningen kan innebära stora materiella skador och kostnader för samhället. För att förebygga dessa behövs mer kunskap om vilka områden i staden som är mest utsatta. Information om var och när stora vattenmängder väntas kClimate change is expected to cause 20-25% heavier rainfall in Sweden which, in combination with the ongoing urbanization, increases the probability of flooding in urban areas. These floods may cause large infrastructural damage and economical costs. Therefore, adequate models for overland flow are needed to identify high-risk areas where mitigating actions should be performed. In this thesis a ne

Now everything is different. Uncertain in a way. We have no idea where we’re going. It seems as if the explanatory models at our disposal aren’t even able to explain where we are today. The world is changing in a pace unprecedented in history. It seems extremely hard to understand how we’re supposed to orient ourselves in such a world. How are we supposed to dream? And what should we dream about?

The usage and potential usage of unmanned aerial vehicles (UAV) in our society grows rapidly and therefore an interest of how to design such a craft was sparked. The ability of an autonomous flight is valuable in many applications and requires that the craft is equipped with a GPS-module. If the connection is lost the UAV’s itinerary may differ from the predetermined one. Because of this an altern

Syfte: Studien syftar till att undersöka om blankning påverkar aktieavkastning på den svenska börsen. Metod: Data, hämtad från Thomson Reuters Datastream, Nasdaq OMX Nordic samt Finansinspektionen, har sammanställts i Microsoft Excel. Regressioner har sedan körts i EViews med den bearbetade datan. Datan testas som en multipel regressionsmodell med paneldata. Tre kontrollvariabler inkluderas. TePurpose: The study aims to investigate whether short selling is affecting the stock return on the Swedish stock market. Methodology: Data, collected from Thomson Reuters Datastream, Nasdaq OMX Nordic and FSA, have been compiled in Microsoft Excel. Regressions were carried out in EViews with the processed data. Data is tested as a multiple regression model with panel data. Three control variables

Denna studie har som syfte att ur ett nätteknisk- såväl som affärsmässigt perspektiv undersöka hur tekniken Vehicle-to-Home (V2H) kan jämna ut effekttoppar och minska belastningen i högt belastade lokalnät. Detta genom att låta elbilens batteri fungera som ett energilager med tvåvägskommunikation mellan bil och hushåll. Projektet har utformats tillsammans med E.ON Elnät i Malmö och behandlar ett eThe aim of this study is to investigate the potential of Vehicle-to-Home (V2H) for reduction of power demand in the local grid during peak hours. Both the technical aspects as well as the economics behind it will be examined. The project has been performed together with the grid operator E.ON in Malmö and covers a grid scenario which is expected in 2030.

One of the most promising alternatives to reduce global CO2 emissions is the replacement of fossil fuels by biofuels in the transportation sector. Production of biofuels from energy crops or residues arises as an answer, but the technology is still costly to be implemented at commercial scale. This project proposes reducing bioethanol production costs by using animal bedding as feedstock. The main

Syftet med studien var att undersöka ledarpersonlighetsdrag och ledarskapsbeteende som efterfrågats hos chefer i 105 jobbannonser som ingått i studien. Fokus för jobbannonserna har varit tre på förhand valda sektorer och arbetstitlar, ekonomichef, försäljningschef och HR-/personalchef. Eftersom samhället ser annorlunda ut idag än vad det gjorde för bara några år sedan har dagens ledare fått en annThe aim of this study was to investigate leadership traits and leadership behavior that is asked for in 105 selected job ads for managerial positions. The focus of the job ads were three pre-selected sectors and job titles, finance manager, sales manager and HR / personnel manager. Because society is different today than it just to be a few years ago, today's leaders have a different role. The

Ambitionen med uppsatsen "När gamla tekniker blir konst – vinylskivan i den digitala tidsåldern" är att analysera dagens vinylentusiasters förhållningssätt till vinylskivor i en kvalitativ undersökning av en diskussionstråd på ett svenskt internetforum. Uppsatsen syftar till att ge en bild av hur man kan se på fenomenet att intressera sig för den föregångna tekniken vinylskivan i en digi

Hur kan man utföra riskfyllda experiment i stor skala utan att det innebär en enorm kostnad? Man låter en dator göra en gissning av resultatet! I detta examensarbete presenteras hur ett simuleringsprogram tog sig an storskalig produktion av vätgas, och vilka utmaningar det medförde.A simulation in bioprocess technology was carried out in order to evaluate the accessibility and adequacy of the simulation software SuperProDesigner used on an academic level. This was done by recreating an existing process and studying the results as well as observing the diculties and limitations along the way. The study in question was a biohydrogen production plant consisting of three parts.

Unsustainability is persistent despite growing awareness that the industrial way of life, its modes of production and consumption need to be transformed. In academic sustainability contexts, however, attention is rarely paid to how industrial societies basically operate and how our everyday life is implicated beyond the usual suspect: consumerism. I argue that it is work, as central social relatio

The modern mobile networks such as the Cloud Radio Network Access (C-RAN) are developing to deal with upcoming requirements in the current generation $4$\textsuperscript{th} Generation (4G) and the upcoming generation i.e. the $5$\textsuperscript{th} Generation (5G). One of the challenges in the modern communication systems is the required high data traffic specially at the fronthaul. Fronthaul in

In the scientific literature and in the media there is a growing concern about toxins in aircraft originating from the air conditioning system as a result from pyrolised jet engine and hydraulic oil, and more recently also de-icing fluid. Many crews have reported long-term neurological and respiratory health effects, but also acute impairment or even incapacitation while performing their flight du

Coreference is a relationship between two or moreexpressions in a text when these expressions referto the same person or thing. Coreference solving,the identification of sets of coreferring mentionsin a text, is a well-studied problem in the fieldof natural language processing (NLP), the com-putational analysis of text. As an example, con-sider this short text:John drove to Judy’s house.He made heIt is said that coreference is difficult to explain, but easy to comprehend; everyoneknows coreference, they just don’t know that they do. We trained a computer toknow it too! Coreference resolution is the identification of phrases that refer to the same entity in a text. Current techniques to solve coreferences use machine-learning algorithms, which require large annotated data sets. Such annota

Studiens syfte är att genom kvalitativa intervjuer i kombination av relevant motivationsforskning och med ett fenomenologiskt angreppsätt förklara och analysera motivation och det idéburna ledarskapet. Empirin är baserad på fyra intervjuer med volontäransvariga inom olika idéburna organisationer. Studiens resultat visar att det finns ett antal faktorer som som är framträdande som motivationskapandThe purpose of this study is to explain and analyze motivation and leadership within non-profit organizations. The study has a qualitative approach, where the empiric is based on five semi-structured interviews, conducted and analyzed using a phenomenlogical approach. The theoretical perspective are based on established theories and research within motivation and the nonprofit sector.

När man skapar ett läkemedel så kan det innehålla både aktiva ämnen och andra hjälpämnen. Hjälpämnena kan bidra till ett läkemedels verkan på flera olika sätt, och en grupp som ofta används är de så kallade cyclodextrinerna. Det finns tre ursprungliga cyclodextriner, alpha beta och gamma, som är ringformade molekyler med olika egenskaper på insidan och utsidan av ringen. På grund av detta så använThe effect of water on α-, β-, and γ-cyclodextrins (CD) was investigated using sorption calorimetry, differential scanning calorimetry and dynamic vapor sorption in order to understand the phase behavior and to create phase diagrams. By relating earlier X-ray diffraction patterns of cyclodextrins equilibrated over saturated salt solutions and literature regarding the cyclodextrin hydrates to the s

What is the relationship between structures of power and the spaces we inhabit? I will propose a description of how the relationship between work and housing has changed since the 19th century, and what relationships of power between worker and employer have been created as a result. I will use four case studies to highlight the changing city through the development of traditional capitalism in

This investigation will analyze how the genre historical fiction, more specifically the novel Falling Angels (2001) written by Tracy Chevalier, can be used in the EFL (English as Foreign Language) classroom in upper secondary school in Sweden. It will argue that the different themes approached by the novel are interesting points of departure to be used in the classroom for both language learning a

Title: How to get started redefining productivity within energy use: A multiple case study of how large tech companies in Silicon Valley get started with creating shared value initiatives for improved energy efficiency Seminar date: 2015-05-26 Course: FEKN90, Degree Project, Master level in Business Strategy, Business Administration, 30 University Credit Points (30ECTS) Authors: Caitlin Bengts