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Background: Early-stage triple-negative breast cancer (TNBC) displays clinical and biological diversity. From a biological standpoint, immune infiltration plays a crucial role in TNBC prognosis. Currently, there is a lack of genomic tools aiding in treatment decisions for TNBC. This study aims to assess the effectiveness of a B-cell/immunoglobulin signature (IGG) alone, or in combination with tumo
Background: Understanding the relationship among changes in Clinical Dementia Rating (CDR), patient outcomes, and probability of progression is crucial for evaluating the long-term benefits of disease-modifying treatments. We examined associations among changes in Alzheimer’s disease (AD) stages and outcomes that are important to patients and their care partners including activities of daily livin
This paper examines a Swedish radio programme where narrators share their stories of revealing a family secret, asking What main recurring themes emerge in the narratives? What are the consequences of revealing a family secret regarding the boundary work around kinship and family? The methods used are qualitative content analysis and reflexive thematic analysis. The result shows some of the ways i
Recent discoveries of several Mesolithic sites within the Dagsmosse Basin, south-central Sweden, offer an opportunity to study the lifestyle and skillsets of Mesolithic hunter-gatherer-fishers operating in wetland environments. In this paper, we present a combined archaeological and palaeoecological analysis of a Mesolithic fenland environment using Repetitive-Proxy Pollen Analysis (RPPA) of early
This study explores how rising economic costs of climate mitigation policies differentially shape climate policy support among the political left and right. To this end, we randomly manipulate how much consumption costs increase as a result of four different climate mitigation policies and study how different cost scenarios influence policy support among a sample of 1,597 Swedish adults. We find t
Inspired by biology, great progress has been made in creating artificial molecular motors. However, the dream of harnessing proteins – the building blocks selected by nature – to design autonomous motors has so far remained elusive. Here we report the synthesis and characterization of the Lawnmower, an autonomous, protein-based artificial molecular motor comprised of a spherical hub decorated with
Gas turbine power plants are popular for offshore power generation due to high power density and their reliability. However, growing usage of renewable energies put gas turbines in a load following backup operation. These power plants suffer part-load efficiency losses when operating at less than full capacity, resulting in higher carbon dioxide (CO2) emission from natural gas combined cycles or h
Introduction: Differentiating Parkinson's disease (PD) from progressive supranuclear palsy (PSP) and multiple system atrophy (MSA) is a common clinical problem. We aimed to apply the T1-/T2-weighted ratio imaging technique, based on standard clinical MRI, to reveal differences in neurodegeneration in three large cohorts. Methods: Three cohorts, with a total of 405 participants (269 PD, 44 PSP, 38
OBJECTIVES: Head and neck cancer (HNC) is the sixth most common cancer worldwide. The condition and its treatment often lead to marked morbidities and, for some patients, premature death. Inferentially, HNC imposes a significant economic burden on society. This study aims to provide a comprehensive and detailed estimation of the cost of illness of HNC for Sweden in 2019.METHODS: This is a prevalen
Studie av den norska krigsfilmen Kampen om Narvik.
Purpose: To assess the impact of fine-needle aspiration cytology (FNAC) in the extent of surgery in patients with thyroid cancer (TC) and the associated surgical morbidity in primary and completion setting. Methods: A Swedish nationwide cohort of patients having surgery for TC (n = 2519) from the Scandinavian Quality Register for Thyroid, Parathyroid and Adrenal surgery between 2004 and 2013 was o
The Swedish electricity system is undergoing a transition unprecedented in both speed and scale, thereby exposing a number of policy-related controversies. In this study, six central themes in the on-going debates around the security of electricity supply in Sweden are identified based on a material of over 1000 news articles, published between the years 2010–2022. By applying the themes to the po
This paper presents a simple and effective control solution to regulate temperature and humidity inside a greenhouse, which are the main climatic variables affecting crop growth and health. A multivariable control strategy with inverted decoupling is proposed in two schemes. The nighttime control scheme uses heating and dehumidification, and the daytime control scheme uses natural ventilation, deh
We consider a two-dimensional point process whose points are separated into two disjoint components by a hard wall, and study the multivariate moment generating function of the corresponding disk counting statistics. We investigate the “hard edge regime” where all disk boundaries are a distance of order [Formula presented] away from the hard wall, where n is the number of points. We prove that as
The European Alps are rapidly losing glacier mass due to climatic warming and are anticipated to be largely ice-free by the year 2100. Long-term glacier monitoring in the Alps provides a record of anthropogenically-driven climate change since the Little Ice Age maximum in ~1850. Understanding these long-term glacier changes provides a basis for mitigating hazards (e.g., mass movements) associated
Optic neuritis (ON) is associated with numerous immune-mediated inflammatory diseases, but 50% patients are ultimately diagnosed with multiple sclerosis (MS). Differentiating MS-ON from non-MS-ON acutely is challenging but important; non-MS ON often requires urgent immunosuppression to preserve vision. Using data from the United Kingdom Biobank we showed that combining an MS-genetic risk score (GR
Background: Following exposure to traumatic stress, women are twice as likely as men to develop mood disorders. Yet, individual responses to such stress vary, with some people developing stress-induced psychopathologies while others exhibit resilience. The factors influencing sex-related disparities in affective disorders as well as variations in resilience remain unclear; however, emerging eviden
DNA mismatch repair (MMR) is thought to contribute to the onset and progression of Huntington disease (HD) by promoting somatic expansion of the pathogenic CAG nucleotide repeat in the huntingtin gene (HTT). Here we have studied constitutional HTT CAG repeat size in two cohorts of individuals with Lynch syndrome (LS) carrying heterozygous loss-of-function variants in the MMR genes MLH1 (n = 12/60;
