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Epidemiology has achieved substantial methodological refinement in recent decades, yet its social resonance has not always kept pace. This essay reflects on tendencies within influential sectors of the field toward methodological sophistication that, while yielding genuine intellectual advances, can unintentionally distance epidemiology from its civic and historical roots. By privileging what is a
Many studies compare health averages between groups such as neighbourhoods or social categories. Averages are simple but can be misleading, since individuals within the same group often differ widely. We present MAIHDA (Multilevel Analysis of Individual Heterogeneity and Discriminatory Accuracy) as a general framework to study how context structures health differences. MAIHDA is not a new statisti
The study analyzed changes in phenolic compounds and the total polyphenol content during peanut sauce cooking, comparing samples prepared with peanuts with and without kernel coating. The peanut sauce formulation consisted of 3.3% w/v peanut powder mixed with water, which was boiled for 2 h at around 100°C. Methanol extracts were used to assess the polyphenol content. Identification and quantifica
Designing composite photocatalytic systems with nanoscale precision is crucial. While conventional facet-selective photo-deposition successfully utilizes spherical co-catalysts, the directed deposition of pre-synthesized two-dimensional (2D) materials onto specific facets remains extremely challenging. This work demonstrates an electrostatic assembly strategy for the precise deposition of 2D trans
In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal antibodies—a deeper understanding of how inflammatory a
The lung may be the organ whose mechanical environment needs to be most finely tuned to achieve optimal function. These needs have to be fulfilled at multiple scales, from proper force transmission between the chest wall and the parenchyma to reduction of surface tension by surfactants inside the alveoli. In addition, a plethora of mechanical loads and forces takes place within the lung, from the
Mobile Stroke Units (MSUs), which are specialised ambulances equipped with brain imaging devices and trained medical personnel, offer the potential for rapid on-site diagnosis and treatment, improving patient outcomes in prehospital stroke care. To fully realise their benefits, it is essential to strategically allocate. However, identifying optimal locations within a region for MSU deployment is t
BACKGROUND: – The arrhythmogenic right ventricular cardiomyopathy (ARVC) risk calculator estimates the risk of incident sustained ventricular arrhythmia (VA) and performs well in ARVC populations meeting 2010 Task Force Criteria. However, the calculator includes no measure of left ventricular (LV) structure and function, while late gadolinium enhancement (LGE) on cardiac magnetic resonance shows p
Context: Pollen-mediated gene flow is crucial for ecological and evolutionary processes and understanding its disruption by anthropogenic disturbances is essential for conservation. Objectives: In this study, we developed landscape connectivity metrics that incorporated hummingbird movement behaviour to assess how structural (amount and configuration) and functional (species-specific behavioural r
Understanding water interactions in complex systems is crucial, as they play a key role in fields such as biochemistry, pharmaceutical formulations, and food science. Nuclear magnetic resonance (NMR) relaxation measurements have become one of the widely used methods to visualize various water characteristics owing to their noninvasive nature and ease of use. However, unambiguous data interpretatio
Understanding the atomic-scale interfaces in advanced semiconductor heterostructures is essential for controlling defects, optimizing material properties, and ensuring device reliability. In this work, we present a comprehensive study of the atomic structure at Al(Ga)N interfaces in N-polar GaN high-electron-mobility transistor structures (HEMTs) via aberration-corrected annular dark field scannin
Epithelial-to-mesenchymal transition (EMT), driven by cues from the tumor microenvironment, is a critical initiator of metastatic progression. In breast cancer patients, elevated expression of cartilage oligomeric matrix protein (COMP) is associated with shorter survival and increased metastatic risk. Here, we investigated the role of COMP in regulating EMT in breast cancer. Breast cancer cells tr
Urban Living Labs (ULLs) are widely promoted as experimental spaces for urban innovation, particularly in EU policy contexts. Yet their design is often shaped by current institutional logics, EU-funding structures, and sector-specific constraints, especially in transport, a domain marked by technical path dependencies and dominant narratives of efficiency and optimization. These conditions risk naUrban Living Labs (ULLs) are widely promoted as experimental spaces for urban innovation, particularly in EU policy contexts. Yet their design is often shaped by current institutional logics, EU-funding structures, and sector-specific constraints, especially in transport, a domain marked by technical path dependencies and dominant narratives of efficiency and optimization. These conditions risk na
Introduction: Traumatic axonal injury (TAI), often caused by rapid rotational forces and high-energy accidents, is common in severe traumatic brain injury (sTBI). The intracranial pressure (ICP) dynamics are often unpredictable, and the need for ICP monitoring remains debated. Research question: What is the incidence of ICP elevation in patients with TAI, and how often is escalated ICP-lowering tr
While the so-called “audiobook boom” has yet to reach academic publishing, thegrowing number of students with print disabilities entering higher education isprompting an increase of academic reading materials in audio formats, such asaudiobooks and text-to-speech software. Despite this, little research exists on students’actual use of audiobooks and text-to-speech in their studies, especially amon
Mercury (Hg) has been stored in permafrost peatlands for millennia. As permafrost thaw is predicted to increase with ongoing climate warming, Hg is at risk to be remobilized from those peatlands and hotspots for Hg methylation could potentially form. Monomethylmercury (MeHg) is a known neurotoxin and a health concern to northern communities if Hg is remobilized, transformed to MeHg and subsequentl
D-dimer has been proven to be an excellent rule-out marker for acute type A aortic dissection (ATAAD) with a sensitivity exceeding 95% while specificity remains low. We hypothesized that the addition of fibrinogen, which is decreased in ATAAD patients due to consumption coagulopathy, would increase predictive ability. This was an exploratory, retrospective, single-region, observational study compa
In the last column, we promised to return to one of the inevitable challenges that vibe coding leaves us with. At the AI Engineer World’s Fair 2025, OpenAI’s Sean Grove claimed that whoever writes the specification is now the programmer since AI can take it from there. Sounds amazing, but what gets lost along the way? To explore this, I’m joined by Jan-Philipp Steghöfer, a researcher at XITASO and
