Aβ antibodies target not only amyloid plaques but also distinct brain cells and vessels
BACKGROUNDAmyloid beta (Aβ) antibodies are the only therapies to slow cognitive decline in Alzheimer's disease (AD). Yet the sites where antibodies engage Aβ in the brain and mechanisms that lower Aβ are not fully understood. Defining Aβ antibody localizations in the brain is essential to understand how immunotherapy is beneficial for AD.METHODSN-terminal Aβ antibody 6E10 was injected via three di
