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Differentiated mammary epithelium shows apicobasal polarity, and loss of tissue organization is an early hallmark of breast carcinogenesis. In BRCA1 mutation carriers, accumulation of stem and progenitor cells in normal breast tissue and increased risk of developing tumors of basal-like type suggest that BRCA1 regulates stem/progenitor cell proliferation and differentiation. However, the function

PURPOSE. To examine in rodent models of retinitis pigmentosa (RP) the expression of the neuroprotectants metallothionein-I and -II and of megalin, an endocytic receptor that mediates their transport into neurons. METHODS. Gene and protein expression were analyzed in retinas of rd1 and rds mice and in those of RCS (Royal College of Surgeons) rats of various ages. Glial cell markers (cellular retina

Owing to the introduction of new diagnostic procedures, such as computed tomography (CT), positron emission tomography (PET) and single photon emission computed tomography (SPECT), the individual dose caused by medical exposures has grown rapidly in the last years. This is especially a subject to radiation protection for nuclear medical diagnosis, since in this case radiopharmaceuticals are admini

The dinosaur fauna of the palynologically dated lower Berriasian Skyttegard Member of the Rabekke Formation on the Baltic island of Bornholm, Denmark, is represented by isolated tooth crowns. The assemblage is restricted to small maniraptoran theropods, assigned to the Dromaeosauridae incertae sedis and Maniraptora incertae sedis. The dromaeosaurid teeth are characterized by their labiolingually c

The B(E2;0+2+) value in 68Ni has been measured using Coulomb excitation at safe energies. The 68Ni radioactive beam was postaccelerated at the CERN on-line isotope mass separator (ISOLDE) facility to 2.9 MeV/u and directed to a 108Pd target. The emitted rays were detected by the MINIBALL detector array. Not only directly registered but also indirectly deduced information on the nucleus emitting th

A key component in successfully managing software products is to properly, and in a timely manner, identify and secure competitive advantage by innovation via feature differentiation. Although open source software (OSS) is not a new idea, several product development companies that operate in a market-driven context have started to use open source solutions as core software components in their prod

In this article it is argued that common sense morality in many cases leads to suboptimal consequences and that human beings in general put too much faith in their moral intuitions. In the first section an explanation of common sense moral is offered. In the second section a working definition of “better world” is presented. In section three, contemporary psychological research concerning human mo

Background: The digestion of food is known to alter the hemodynamics of the body significantly. The purpose of this study was to study the postprandial changes in stroke volume (SV), cardiac output (CO) and left ventricular (LV) longitudinal systolic and diastolic functions measured with tissue Doppler imaging, in relation to gastric emptying rate (GER), satiety, and glucose and insulin concentrat

Introduction: Despite the high incidence of appendicitis, the diagnosis is often delayed in children. A delayed diagnosis may lead to perforation and formation of an abscess. The treatment of an appendiceal abscess is still a debatable subject and studies have not agreed on what strategy to use. Some prefer immediate operation, whereas others advocate conservative management with or without interv

This text deals with the phenomenon of today’s rune carvers in the Nordic area. By using symbols of antiquity in their craftsmanship, the rune carvers revive an act that is historically significant and bears aspects of identity in the past as well as today. Why do people carve and erect runes stones today? When and where is it done? What are the explicit or implicit purposes? The text tries to ans

Ciliate assemblages play a significant role in the microbial food web. The effects of environmental temperature on assemblage composition may be influenced by abiotic factors such as seasonality and disturbance, but the effects of temperature on ciliate assemblages found on different substrata have not been explored. Sandy bottoms and submerged rocks harbour dissimilar ciliate assemblages, and it

Recension av Sam Nilsson, T-kontoret. Underrättelsetjänst och västsamarbete.

Klass är i ropet igen. I kulturtidskrifter pågår intensiva diskussioner om begreppet. I denna text föreslår jag att vi borde analysera hur klass konstrueras i olika sammanhang för att förstå konstruktionens betydelse för nuet och den historiska utvecklingen.

Increasing precipitation and surface water temperature due to global change may strengthen the salinity gradient in coastal regions, which could influence the behaviour of dinoflagellate migration. We studied diel vertical migration (DVM) behaviour in the dinoflagellates Prorocentrum minimum and Heterocapsa triquetra using vertically stratified laboratory columns with 3 different salinity gradient

The four proton-hole nucleus Pt-204 was populated in the fragmentation of an E/A = 1 GeV Pb-208 beam. The yrast structure of Pt-204 has been observed up to angular momentum I = 10h by detecting delayed gamma-ray transitions originating from metastable states. These long-lived excited states have been identified to have spin-parities of I-pi = (10(+)), (7(-)), and (5(-)) and half-lives of T-1/2 = 1

The central nervous system (CNS) monitors modifications in metabolic parameters or hormone levels and elicits adaptive responses such as food intake regulation. Particularly, within the hypothalamus, leptin modulates the activity of pro-opiomelanocortin (POMC) neurons which are critical regulators of energy balance. Consistent with a pivotal role of the melanocortin system in the control of energy