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Surface water pollution consists of various pollutants like heavy metals (Cu, Cr, Pb, and Ni), metalloids (Se, As, and Ag), and organic pollutants (dyes, antibiotics, pharmaceuticals, pesticides, and phenolic compounds). The escalating issue of water pollution requires innovative solutions for mitigation and climate resilience. Although various advanced techniques are being developed for removing
AbstractBackground: Identification of patients at risk and prevention of acute postoperative pain (APOP) are central to individualized anesthesia and analgesia. Venous cannulation pain (VCP) has shown promise as a predictor of APOP. In the PeriOPerative Individualization Trial (POPIT), VCP was evaluated as a pain-sensitivity stratification method to guide anesthesia and reduce postoperative pain.
The downstream process of monoclonal antibodies (mAbs) is expensive and significantly contributes to overall manufacturing costs. One primary reason is the extensive consumption of water and chemicals required for preparing large volumes of various buffers, essential for multiple chromatography and filtration steps. Reducing the water consumption in biopharmaceutical processes is critical to drive
We update the HOMER method, a technique to solve a restricted version of the inverse problem of hadronization – extracting the Lund string fragmentation function f (z) from data using only observable information. Here, we demonstrate its utility by extracting f (z) from synthetic PYTHIA simulations using high-level observables constructed on an event-by-event basis, such as multiplicities and shap
Intolerance of uncertainty (IU), cognitive avoidance (CA), positive beliefs about worry (PBW) and a tendency to view everyday problems as threats, termed negative problem orientation (NPO), are cognitive vulnerabilities associated with symptoms of anxiety and depression in adults, with fewer studies examining all four vulnerabilities in youth. In this study, validated measures of IU, CA, PBW and N
Background and purpose: Neuroblastoma is the most common extracranial solid tumour in children. Radiotherapy is commonly part of the multimodal treatment for high-risk patients. The aim of this study is to analyse doses to organs at risk (OAR) in comparative proton and photon treatment plans for children treated for neuroblastoma and report side effects. Patient/material and methods: All children
Background Labels for neck pain after a motor vehicle crash (MVC) influenced recovery expectations and management preferences. Research is needed to understand why these expectations and preferences varied based on the label given. Aim To explore how people perceive different labels for neck pain after an MVC. Methods We performed a content analysis of qualitative data from a randomised controlled
Heme proteins are central to metabolism and stress responses but remain challenging to express recombinantly due to cytotoxicity and folding constraints. Phytoglobins (Pgbs) exemplify these difficulties, as expression protocols often fail to translate across protein species. Here, we used a cell-free protein synthesis (CFPS) platform powered by digital microfluidics to screen expression determinan
District heating is critical for low-carbon urban energy systems, yet most networks remain centralized in both heat generation and data ownership, fossil-dependent, and poorly integrated with digital, customer-centric, and market-responsive solutions. While artificial intelligence (AI), the Internet of Things (IoT), and automation offer transformative opportunities, their adoption raises complex c
Introduction: Doxorubicin (DOX), a potent anthracycline, is widely used in cancer therapy, but its effect is limited by doxorubicin-induced cardiotoxicity (DIC). Increasing evidence suggests that DIC is associated with ferroptosis, a cell death characterized by the iron-dependent accumulation of lipid peroxides. Although aerobic exercise is recommended for chemotherapy-related cardiac dysfunction,
Epilepsy is a prevalent neurological disorder characterized by spontaneous recurrent seizures (SRS). Epileptogenesis is a multifaceted pathophysiological process that transforms a normal brain into one prone to chronic seizures. Targeting epileptogenesis is a compelling line of epilepsy therapy. Thus, discovering new drugs that oppose, mitigate, or modify epileptogenesis is a significant challenge
The life of Jerome of Stridon (d. 419/420), who was regarded as a father of the church and one of the most important authorities in the Middle Ages, has often been depicted as highly controversial: In modern reconstructions, Jerome is typically described as an outsider, constantly involved in controversies and frequently criticized and questioned by his contemporaries. This begs the question of ho
The intervention Balancing Everyday Life™ (BEL) helps service users achieve a balance among everyday activities and enhance personal recovery. BEL builds upon research for people with mental illness and on evidence from earlier activity-based interventions. This methodological paper presents the theoretical basis for BEL, which rests on five pillars of theories and models. Further, the BEL topics
At the heart of P. F. Strawson’s naturalistic approach to responsibility sits the Inescapability Claim. The main argument of this article is that the established interpretation of this claim is mistaken. According to, what I will call, the Standard Reading, it is the empirical claim that it is psychologically impossible for us to abandon our responsibility practices. Although widespread, this read
Context. Differentiating between in situ and accreted populations in the Milky Way halo is a challenging task. Various kinematic spaces are often used to identify distinct accreted populations from the in situ Milky Way halo. However, this approach has limitations, especially at low orbital energies. To overcome this ambiguity, elemental abundances are typically used to distinguish between populat
Ubiquitously used for monitoring pipelines and infrastructures, distributed fibre-optic acoustic sensing is becoming an emerging technology for earthquake monitoring thanks to the possibility to interrogate a large vast of distances with a dense number of sensing points in which an optical fiber cable can be retrofitted. Moreover, it can also be used as a tool by geophysicists for the characteriza
A fundamentally crucial suggestion to rectify the fits to the high-resolution X-ray photoelectron spectroscopy (XPS) raw data for the S 2p core level published by Dirin et al. (Nano Lett. 2023, 23 (5), 1914–1923) is presented herein.
Cognition in children with cerebral palsy (CP) is often affected. How cognition differs by functional level and subtype is not clear, and the effects of adapted response modes need investigation. In this study, the aims were to investigate how many psychologists reported that interpreters and/or augmentative and alternative communication (AAC) were used, how many assessments were adapted, if there
