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PI Alexander Pietras BackgroundGlioblastoma multiforme (GBM) the highest-grade glioma and deadliest brain tumor occurs in pediatric as well as adult patients. Despite aggressive treatment with surgery, irradiation and sometimes chemotherapy, tumors invariably recur as incurable lesions. Tumor cells with stem cell characteristics are thought to be responsible for therapeutic resistance in brain tum
https://www.tcr.lu.se/research-groups/brain-tumor-biology - 2026-04-25
Our research
https://www.tcr.lu.se/development-biology - 2026-04-25
PI Kristian Pietras Our researchOur aim is to molecularly map support functions performed by the various cell types comprising the tumor microenvironment. We believe that decisive treatment benefit can only be achieved by targeting several of the cell types that collectively sustain tumor growth. Importantly, the cellular networks within tumors cannot be studied in isolation. Thus, our work ranges
https://www.tcr.lu.se/research-groups/experimental-oncology - 2026-04-25
PI Lars Rönnstrand BackgroundThe receptor tyrosine kinases KIT and FLT3 are both important regulators of development and maintenance of a number of different cell types. Deregulation of these receptors by mutations has been implicated in various human malignancies, including akut myeloid leukemia and melanoma. The signaling pathways activated by the oncogenic mutants are to some extent unique and
https://www.tcr.lu.se/research-groups/molecular-cancer-research - 2026-04-25
PI Kazi Julhash Uddin BackgroundDespite incredible progress in the treatment of cancer, the cure rate remains low due to the fact that almost all cancer patients develop resistance to anticancer therapies. This results in as many as 90% of cancer-related deaths in various types of cancer. Consequently, identification of the factors that drive the development of therapy resistance is a pressing is
https://www.tcr.lu.se/research-groups/molecular-cancer-medicine - 2026-04-25
The Medical Protein Chemistry research group headed by prof. Anna Blom is located at the Wallenberg Laboratory within Skåne University Hospital in Malmö. The group is focused on the complement system in health and disease. Our ambition is to make high quality basic science based on clinically relevant questions and yielding novel diagnostic approaches and clinical interventions. Our research is su
https://www.protein-chemistry.lu.se/anna-blom-research-group-0 - 2026-04-25
The Medical Protein Chemistry research group headed by prof. Anna Blom is located at the Wallenberg Laboratory within Skåne University Hospital in Malmö. The group is focused on the complement system in health and disease. The complement, crucial part of innate immune system is involved in many basic biological processes such as defence against infections but when activated in a wrong place or no
https://www.protein-chemistry.lu.se/protein-chemistry-research-group - 2026-04-25
Best publications from our group over past years. King B.C., Kulak K, Krus U., Rosberg R., Golec E., Wozniak K., Gomez M.F., Zhange E., O'Connell D., Renström E. and Blom A.M. (2019) Complement C3 proteinst against autophagy related beta-cell detah via ATG16L1 interaction and regulation of autophagy., Cell Metabolism, 29, 202-210.Kulak K., Kuska K., Colineau L., Mckay M., Maziarz K., Slaby J., Blo
https://www.protein-chemistry.lu.se/top-publications - 2026-04-25
List of selected publications from our research group exemplifying the projects we are conducting. Blom. A. M., Pertoft H. and Fries E. (1995) Inter-a-inhibitor is required for the formation of the hyaluronan-containing coat on fibroblasts and mesothelial cells. J. Biol. Chem., 270, 9698-9701. Blom A. M., Mörgelin M., Öyen M., Jarvet J. and Fries E. (1999) Structural characterization of inter-a-in
https://www.protein-chemistry.lu.se/top-publications/selected-publications-group - 2026-04-25
In blood, complement proteins are a major component and perhaps therefore most of these were identified already decades ago. However, only in recent years it has become apparent that complement not only plays a major role in innate defense against pathogens but also identifies foreign materials and removes waste (immune complexes and dying cells). The physiological relevance of complement is demon
https://www.protein-chemistry.lu.se/projects - 2026-04-25
We are studying an unexpected role of complement – in the physiology and metabolism of pancreatic beta-cells. Surprisingly, this is related to intracellular functions of complement and therefore changes the way we perceive this “blood” system and will likely inspire discovery of many other intracellular effects of complement. We study the role of intracellular complement factor C3 and membrane bou
https://www.protein-chemistry.lu.se/projects/insulin-and-immunity-when-complement-takes-control - 2026-04-25
As a first line of defense against pathogens and a mediator between innate and adaptive immunity, complement is a particular focus of evasion strategies developed by pathogens. We showed that one common strategy is to bind complement inhibitor C4BP, which leads to decreased opsonisation of bacteria with C3b impairing phagocytosis and allowing bacterial survival. It appears that binding of C4BP is
https://www.protein-chemistry.lu.se/projects/bacterial-complement-evasion-strategies - 2026-04-25
Misguided or excessive complement activation is involved in many common diseases such as rheumatoid arthritis, systemic lupus erythematosus, vasculitis and age-related macula degeneration. In collaboration with clinicians we are studying molecular mechanisms of complement involvement in these diseases. Joint inflammation in rheumatoid arthritis (RA), a common chronic inflammatory disease that ca
https://www.protein-chemistry.lu.se/projects/pathologic-complement-activation-diseases - 2026-04-25
Complement-dependent cytotoxicity is one of the mechanisms by which therapeutic monoclonal antibodies are toxic to cancer cells. Also, complement is currently undergoing re-appreciation of its role in the immune surveillance of tumors. The majority of human tumors are low immunogenic and complement may be involved in their recognition via direct “danger signal” elicited activation. This in turn at
https://www.protein-chemistry.lu.se/projects/complement-and-cancer - 2026-04-25
Complement has recently gained substantial worldwide attention, as it was discovered that several common diseases such as age-related macular degeneration (blindness in elderly) are related to deregulation of the balance between complement activation and inhibition. Full complement deficiencies lead to severe infectious and autoimmune diseases but are uncommon while it appears that we are just beg
https://www.protein-chemistry.lu.se/projects/inherited-deficiencies-complement-inhibitors - 2026-04-25
You can reach us by mailor by calling 040-33 78 30 and 040-33 15 20Vaishnavi Dandavate, postdoctoral fellowE-mail: vaishnavi [dot] dandavate [at] med [dot] lu [dot] se (vaishnavi[dot]dandavate[at]med[dot]lu[dot]se)Daniel Chacón Arguedas, postdoctoral fellowE-mail: daniel [dot] chacon_arguedas [at] med [dot] lu [dot] seLucia Fernandez-Nevado, postdoctoral fellowE-mail: lucia [dot] fernandez_nevado
https://www.protein-chemistry.lu.se/members-our-research-group - 2026-04-25
Here you can find description of open positions and internships in our research group. MSc StudentsWe often can offer thesis projects for Masters students within the projects conducted in our group. Please, contact Anna Blom (Anna [dot] Blom [at] med [dot] lu [dot] se (Anna[dot]Blom[at]med[dot]lu[dot]se)) directly for more details.PhD StudentsWe are always interested in reviewing PhD students appl
https://www.protein-chemistry.lu.se/open-positions - 2026-04-25
Research funding supporting projects conducted in our research group: Swedish Research Council Cancerfonden Torsten Söderberg Foundation ALF Knut and Alice Wallenberg Foundation Novo nordisk fonden Erling-Persson Family Foundation Alfred Österlund Foundation Grants for clinical research from Skåne University Hospital (including cancer) King Gustav Vth, 80-years Anniversary Foundation Diabetesfond
https://www.protein-chemistry.lu.se/research-funding - 2026-04-25
Medical Protein Chemistry Group. Who are we? Professor Anna Blom leads the Medical Protein Chemistry group Projects conducted in our research group Open positions Lund University Diabetes Centre Department of Translational Medicine
https://www.protein-chemistry.lu.se/protein-chemistry - 2026-04-25
