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The development of treatment resistance remains universal for patients with metastatic prostate cancer, driven by androgen receptor alterations and lineage state transitions. Identifying the evolution of lineage transitions in treatment resistance has been limited by the challenges of collecting serial tissue biopsies on treatment, which can be overcome using blood-based liquid biopsies. Using a n
Aedes albopictus, a key vector for Dengue, Chikungunya, Zika, and Yellow Fever, is expanding its range beyond its tropical and subtropical origins, driven by suitable climate, population mobility, trade, and urbanization. Since its introduction to Europe, Ae. albopictus has rapidly spread and triggered recurrent outbreaks. Past model attempts have handled vector suitability and vector introduction
Background Suicide attempts are common in youth and have potentially lethal outcomes. Effective treatments targeting suicide attempts are scarce. Objective To assess the feasibility and preliminary efficacy of a family-based cognitive behavioural treatment relative to an active control for youth with suicidal behaviour. Methods 30 youths (93% female; mean (SD) age=14.6 (1.5) years) residing in Swe
Background: Higher meat intake has been associated with adverse health outcomes, including cardiovascular disease (CVD). This study investigated plasma metabolites associated with meat intake and their relation with cardiometabolic biomarkers, subclinical CVD markers, and incident CVD. Methods: Associations between self-reported meat intake and 1272 plasma metabolites were investigated in the SCAP
Changes in drug use in the general population during the COVID-19 pandemic and their long-term consequences are not well understood. We employed natural language processing and machine learning to analyse a large dataset of self-reported rates of and reasons for drug use during the pandemic, along with their associations with anxiety, depression and substance use problems post-pandemic. Our findin
We investigated the mRNA expression of G protein-coupled receptors (GPCRs) in cells from four human vascular beds: umbilical vein (HUVEC), microvasculature (MVEC), aorta (HAEC), and coronary artery (CAEC). Our study revealed that the orphan receptor ELTD1 (ADGRL4) was the most abundantly expressed GPCR mRNA in all four EC types. When recombinantly expressed in U87 cells, ELTD1 receptors activated
Density functional theory (DFT) thermochemistry of 3d transition-metal complexes is well-known to be sensitive to the amount of exact Hartree-Fock exchange incorporated into the exchange-correlation functional. For example, relative energies of different protonation states of iron-sulfur complexes may vary by hundreds of kJ/mol among different DFT methods. In the present study, we examine the rela
Background: Unhealthy lifestyle behaviours, including unhealthy alcohol consumption, physical inactivity, smoking, and nonadherence to dietary recommendations, are major contributors to non-communicable diseases and mortality. While adopting healthy behaviours can reduce these risks in middle-aged adults, research is limited. Therefore, the aim of this study was to assess the distribution of unhea
OBJECTIVE: We previously demonstrated that artificial intelligence (AI)-directed chest computed tomography (CT)-based total opacity scores (TOS) are associated with high-risk obstructive sleep apnea (OSA) based on the Berlin Questionnaire. In the current study, we examined the association between TOS severity and OSA severity based on polysomnography (PSG) recordings among participants with a hist
Study region: The Tibetan Plateau (TP) is a high-altitude region characterized by harsh environmental conditions and limited accessibility, making the monitoring of its numerous lakes a significant challenge. This region is crucial for hydrological studies, and its numerous lakes play an important role in regional water dynamics and climate change research. Study focus: This study evaluates the ap
There is active crosstalk between tumor cells and the tumor microenvironment during metastatic progression, a process that is significantly affected by obesity, particularly in breast cancer. Here we analyze the impact of a high fat diet (HFD) on metastasis, focusing on the role of platelets in the formation of premetastatic niches (PMNs). We find that a HFD provokes pre-activation of platelets an
Methanol is a promising renewable fuel that can be used to reduce the carbon intensity of internal combustion engines. In any combustion strategy with methanol, both unburned methanol and formaldehyde emissions are criteria pollutants that are potential drawbacks, so their accurate measurement is critical. The flame ionization detectors (FIDs) typically used in engine research to measure unburned
Japan’s rich archaeological record, supported by well-established chronological and typological frameworks, offers valuable opportunities to investigate prehistoric socio-cultural responses to climate change, although comprehensive studies remain limited. This exploratory paper examines the impact of climatic disruptions—particularly the 8.2 ka event—on Jomon foragers in Kyushu, aiming to develop
Aims: Studies have shown the association between personal history of diabetes mellitus (DM type 1/2) and risk of colorectal cancer (CRC). This study aims to find the association between the family history of diabetes and CRC risk. Methods: This large nationwide cohort study leveraged data from several Swedish nationwide registers (follow-up: 1964–2018) to compare the risk using standardized incide
Background: Gambling disorder severely impacts the affected individual's daily life and is considered to be a major public health issue. Gambling disorder may be a risk factor for suicidal behavior, but matched case-control studies are few. This study aims to explore suicidal behavior, and risk factors for it, among patients with GD in comparison with age- and gender-matched controls. Methods: Thi
Objective: Although patients prefer describing their problems using words, mental health interventions are commonly evaluated using rating scales. Fortunately, recent advances in natural language processing (i.e., AI-methods) yield new opportunities to quantify people's own mental health descriptions. Our aim was to explore whether responses to open-ended questions, quantified using AI, provide ad
In analysing five dimensional orbifolds with exceptional gauge groups, we seek to find stable vacua configurations which satisfy the minimal requirements for asymptotic grand unified models. In this respect we show that no minimal asymptotic grand unified theory can be built. Our results point towards non-minimal models based on E6: one featuring supersymmetry, and the other needing a modification
Background: Stroke and acute myocardial infarction (AMI) rank among the leading causes of mortality. Physical activity and exercise are recommended as part of rehabilitation after AMI to prevent cardiovascular events, but the importance for stroke prevention has not been investigated using population-based data. Objectives: To determine associations between participation in exercise-based cardiac
